Cited by 29Substance Abuse Treatment and OutcomesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesSleep and related disorders

Psychological Distress and Adaptational Problems Associated with Discontinuation of Benzodiazepines

O’Connor, Kieron, Bélanger, Lynda, Marchand, André, Dupuis, Gilles, Elie, Robert, Boyer, Richard·1999·Addictive Behaviors

Abstract

This study compared subjects who had received standard tapered withdrawal of benzodiazepine (BZD) (group 1) with a group with comparable diagnosis still receiving BZD (group 2) and a control group of comparable diagnosis not yet receiving treatment (group 3). Sixty subjects aged 21-65 years with a diagnosis of nonpsychotic anxiety or insomnia were included. The assessment of psychological distress and quality of life was timed to coincide with the maximum immediate effect of BZD discontinuation, as calculated according to drug half-life. Subjects diagnosed with insomnia reported lower distress in all three groups. The pattern of distress experienced by group 1 was closer to group 3 than to group 2, indicating the potential importance of re-emergence of anxiety. High neuroticism, lower education level, and lower quality of life were associated with higher levels of distress during withdrawal.

Integrity signals

Registry

Crossref · 10.1016/s0306-4603(98)00107-5

Cites

17 of 17 references verified0 citation errors · 0 not checkable

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Authors
O’Connor, K., Bélanger, L., Marchand, A., Dupuis, G., Elie, R., & Boyer, R.
Affiliations
  • Institut universitaire en santé mentale de Montréal (CA)
  • Université du Québec à Montréal (CA)
Corresponding author
O’Connor, Kieron
Venue
Addictive Behaviors
Publisher
Elsevier BV
Published
1999-07
Volume
24
Issue
4
Pages
537-541
ISSN
0306-4603 (ISSN-L)
OpenAlex
W2020069531
Cited by
29
References
18
Citations by year
2025: 1 · 2024: 1 · 2021: 2 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Addictive Behaviors (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
benzodiazepine withdrawal, benzodiazepine tapering, psychological distress, anxiety, insomnia, quality of life, neuroticism, educational attainment, elimination half-life
MeSH terms
Adaptation, Psychological, Adult, Aged, Anxiety Disorders, Benzodiazepines, Female, Health Status Indicators, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Personality Inventory, Quality of Life, Stress, Psychological, Substance Withdrawal Syndrome

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