Spatiotemporal T790M heterogeneity in a patient with EGFR-mutant non–small cell lung cancer
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Resistance to TKIs is often heterogeneous, with separate metastases showing different resistance mechanisms.
“acquired resistance to TKIs is frequently heterogeneous, with different metastatic tumor deposits demonstrating distinct underlying mechanisms (15,35,36).”
From Detection of T790M, the Acquired Resistance <i>EGFR</i> Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses (2016) · cites this paper as [36]
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Cites
Detection of Mutations in <i>EGFR</i> in Circulating Lung-Cancer Cells
Maheswaran, S., Sequist, L. V., Nagrath, S., Ulkus, L., Brannigan, B., Collura, C. V., Inserra, E., Diederichs, S., Iafrate, A. J., Bell, D. W., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0800668 · Cited by 1,617 · see citing works
Optimization of Dosing for EGFR-Mutant Non–Small Cell Lung Cancer with Evolutionary Cancer Modeling
Chmielecki, J., Foo, J., Oxnard, G. R., Hutchinson, K. E., Ohashi, K., Somwar, R., Wang, L., Amato, K. R., Arcila, M. E., Sos, M. L., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002356 · Cited by 520 · see citing works
Hata, A., Katakami, N., Kaji, R., Fujita, S., & Imai, Y. (2013) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e318282e047 · Cited by 19 · see citing works
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Sundaresan, T. K., Sequist, L. V., Heymach, J. V., Riely, G. J., Jänne, P. A., Koch, W. H., Sullivan, J. P., Fox, D. B., Maher, R., Muzikansky, A., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1031 · Cited by 347 · see citing works
- Authors
- Hata, A., Masago, K., Katakami, N., Imai, Y., & Yatabe, Y.
- Affiliations
- Foundation for Biomedical Research and Innovation (JP)
- Corresponding author
- Hata, Akito
- Venue
- Journal of Thoracic Oncology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 9
- Issue
- 8
- Pages
- e64-e65
- ISSN
- 1556-0864 (ISSN-L)
- OpenAlex
- W2063790560
- Cited by
- 8
- References
- 3
- Citations by year
- 2024: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2015: 2
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thoracic Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Keywords
- T790M mutation, EGFR mutation, non-small cell lung cancer, spatiotemporal heterogeneity, acquired resistance, tumor heterogeneity
- MeSH terms
- Gefitinib, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Mutation, Quinazolines, Genetic Heterogeneity, Spatio-Temporal Analysis, ErbB Receptors
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