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Cited by 18Heart Failure Treatment and ManagementThyroid Disorders and TreatmentsCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Free Triiodothyronine Levels and Short-Term Prognosis in Chronic Heart Failure Patients With Type 2 Diabetes

Chen, Pingan, Li, Shaonan, Lei, Xiaoming, Liu, Zhen, Luo, Yi, Wu, Daihong, Xu, Dingli·2015·The American Journal of the Medical Sciences
DOI 10.1097/maj.0000000000000524
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Abstract

Background In chronic heart failure (CHF) patients with type 2 diabetes mellitus (T2DM), the role of thyroid hormone (TH) in predicting CHF severity and prognosis is unclear. The authors therefore investigated the role of TH in predicting CHF severity and prognosis in these specific patients.Methods A total of 224 CHF patients (114 with T2DM) over a mean follow-up time of 6.56 ± 0.18 months were studied. TH, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and other parameters were measured.Results Free triiodothyronine (FT3) levels were lower in the T2DM group compared with the nondiabetes group (P = 0.026) and higher in the New York Heart Association (NYHA) I group than in the NYHA III and IV groups (both P < 0.05). Compared with the low NT-proBNP group, the high NT-proBNP group had lower FT3 levels (P < 0.01). NT-proBNP correlated with NYHA classes (r = 0.541, P < 0.001), and inversely correlated with left ventricular ejection fraction (r = -0.431, P < 0.001) and FT3 levels (r = -0.335, P < 0.001). In multiple linear regression analysis, NT-proBNP was significantly correlated with NYHA classes (P < 0.001), left ventricular ejection fraction (P < 0.001) and FT3 (P = 0.004). Kaplan-Meier curves showed that the low FT3 group had an increased rate of short-term adverse outcomes of CHF (log rank, χ = 9.794, P = 0.002).Conclusions FT3 levels are associated with the severity of CHF and seem to reflect short-term outcomes in CHF patients with T2DM.

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  1. Celani, 1994, Prevalence of abnormal thyrotropin concentrations measured by a sensitive assay in patients with 2 diabetes mellitus, Diabetes Res, 27, 15

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Metadata

Authors
Chen, P., Li, S., Lei, X., Liu, Z., Luo, Y., Wu, D., & Xu, D.
Affiliations
  • Nanfang Hospital (CN)
  • Guangzhou First People's Hospital (CN)
Corresponding author
Chen, Pingan
ORCID
Venue
The American Journal of the Medical Sciences
Publisher
Elsevier BV
Published
2015-08
Volume
350
Issue
2
Pages
87-94
ISSN
0002-9629 (ISSN-L)
DOI
10.1097/maj.0000000000000524
OpenAlex
W2250187174
Cited by
18
References
38
Citations by year
2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2
FWCI
1.45
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of the Medical Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
free triiodothyronine, chronic heart failure, type 2 diabetes, thyroid hormones, NT-proBNP, NYHA functional class, left ventricular ejection fraction, short-term prognosis, heart failure severity
MeSH terms
Aged, Chronic Disease, Diabetes Mellitus, Type 2, Echocardiography, Female, Heart Failure, Humans, Male, Middle Aged, Prognosis, Triiodothyronine

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