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Free Triiodothyronine Levels and Short-Term Prognosis in Chronic Heart Failure Patients With Type 2 Diabetes
Abstract
Background In chronic heart failure (CHF) patients with type 2 diabetes mellitus (T2DM), the role of thyroid hormone (TH) in predicting CHF severity and prognosis is unclear. The authors therefore investigated the role of TH in predicting CHF severity and prognosis in these specific patients.Methods A total of 224 CHF patients (114 with T2DM) over a mean follow-up time of 6.56 ± 0.18 months were studied. TH, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and other parameters were measured.Results Free triiodothyronine (FT3) levels were lower in the T2DM group compared with the nondiabetes group (P = 0.026) and higher in the New York Heart Association (NYHA) I group than in the NYHA III and IV groups (both P < 0.05). Compared with the low NT-proBNP group, the high NT-proBNP group had lower FT3 levels (P < 0.01). NT-proBNP correlated with NYHA classes (r = 0.541, P < 0.001), and inversely correlated with left ventricular ejection fraction (r = -0.431, P < 0.001) and FT3 levels (r = -0.335, P < 0.001). In multiple linear regression analysis, NT-proBNP was significantly correlated with NYHA classes (P < 0.001), left ventricular ejection fraction (P < 0.001) and FT3 (P = 0.004). Kaplan-Meier curves showed that the low FT3 group had an increased rate of short-term adverse outcomes of CHF (log rank, χ = 9.794, P = 0.002).Conclusions FT3 levels are associated with the severity of CHF and seem to reflect short-term outcomes in CHF patients with T2DM.
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“Furthermore, in addition to conventional risk factors, TH metabolism alterations have been associated with a worse prognosis in patients with both ischemic and nonischemic LV dysfunction in both acute decompensated and chronic stable HF (131-133).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [131]
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Thyroid Hormones and Cardiovascular Function and Diseases
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Metadata
- Authors
- Chen, P., Li, S., Lei, X., Liu, Z., Luo, Y., Wu, D., & Xu, D.
- Affiliations
- Nanfang Hospital (CN)
- Guangzhou First People's Hospital (CN)
- Corresponding author
- Chen, Pingan
- Venue
- The American Journal of the Medical Sciences
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 350
- Issue
- 2
- Pages
- 87-94
- ISSN
- 0002-9629 (ISSN-L)
- OpenAlex
- W2250187174
- Cited by
- 18
- References
- 38
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of the Medical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- free triiodothyronine, chronic heart failure, type 2 diabetes, thyroid hormones, NT-proBNP, NYHA functional class, left ventricular ejection fraction, short-term prognosis, heart failure severity
- MeSH terms
- Aged, Chronic Disease, Diabetes Mellitus, Type 2, Echocardiography, Female, Heart Failure, Humans, Male, Middle Aged, Prognosis, Triiodothyronine
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