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Cited by 59Parasitic infections in humans and animalsParasites and Host InteractionsParasitic Diseases Research and Treatment

The DOI matches its Crossref record; 40 of the 42 references it cites were found in a registry or an index.

Albendazole for the Treatment of Human Echinococcosis: A Review of Comparative Clinical Trials

Falagas, Matthew E., Bliziotis, Ioannis A.·2007·The American Journal of the Medical Sciences
DOI 10.1097/maj.0b013e31814252f8
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Abstract

Background Albendazole has been used in various ways in the treatment of cystic echinococcosis (CE). Methods We reviewed the available evidence regarding the role of albendazole for the treatment of patients with CE. The available comparative clinical trials (randomized or not) that examined the use of albendazole in CE were identified from the PubMed and the ISI Web of Science databases. Relevant data from the trials were extracted and evaluated. Results Thirteen studies were included in the review. Albendazole is superior to placebo for inoperable, symptomatic patients (1 study). In addition, in 4 trials that tested albendazole as a preoperative adjuvant therapy, the drug resulted in degeneration of hydatid cysts at the time of surgery in a considerable proportion of patients. Furthermore, combined therapy with albendazole and PAIR (Puncture, Aspiration, Injection of scolicidal agent, and Re-aspiration) technique was found more effective than albendazole or PAIR treatment alone, in a randomized controlled trial examining this issue. Finally, although existing evidence shows some superiority for albendazole compared to mebendazole, there is no definite proof about this. Conclusions Although the available comparative trials provide considerable evidence for the role of albendazole in patients with CE, there are some important clinical questions that remained unanswered by the studies. One of them is whether the combination of albendazole with praziquantel is superior to albendazole alone when both effectiveness and drug toxicity are taken into account. Also, further studies should also compare the combination of albendazole/PAIR with albendazole/surgery focusing on both short and long term outcomes.

Overview

Integrity signals

Registry

Crossref · 10.1097/maj.0b013e31814252f8

Cites

40 of 40 references verified0 citation errors · 0 not checkable

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Verification

Claims the paper makes

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • PAIR in combination with albendazole or mebendazole has been evaluated as a highly useful strategy for managing cystic hydatidosis.

    “this method (PAIR) in combination with albendazole or mebendazole has been evaluated as a highly useful strategy for managing cystic hydatidosis [174,175,181,182]”

    From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [175]

Citations

Cites

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2 of the 42 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Casado, 2001, Combined praziquantel and albendazole chemoprophylaxis in experimental hydatidosis, Parasitol Res, 87, 787, 10.1007/s004360100443 · DOI
  2. Moreno, 2001, Praziquantel and albendazole in the combined treatment of experimental hydatid disease, Parasitol Res, 87, 235, 10.1007/s004360000334 · DOI
  3. Urrea-Paris, 2000, In vitro effect of praziquantel and albendazole combination therapy on the larval stage of Echinococcus granulosus, Parasitol Res, 86, 957, 10.1007/PL00008526 · DOI

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Metadata

Authors
Falagas, M. E., & Bliziotis, I. A.
Affiliations
  • Tufts University (US)
  • Alfa Institute of Biomedical Sciences (GR)
Corresponding author
Falagas, Matthew E.
ORCID
Falagas, Matthew E.
Venue
The American Journal of the Medical Sciences
Publisher
Elsevier BV
Published
2007-09
Volume
334
Issue
3
Pages
171-179
ISSN
0002-9629 (ISSN-L)
DOI
10.1097/maj.0b013e31814252f8
OpenAlex
W2061189349
Cited by
59
References
42
Citations by year
2026: 2 · 2025: 5 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 3 · 2014: 8 · 2013: 5 · 2012: 2
FWCI
0.48
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of the Medical Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic infections in humans and animals
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Keywords
albendazole, echinococcosis, mebendazole, praziquantel, PAIR technique, adjuvant therapy, drug toxicity, antiparasitic treatment
MeSH terms
Anthelmintics, Clinical Trials as Topic, Echinococcosis, Humans, Mebendazole, Placebos, Albendazole, Controlled Clinical Trials as Topic

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