The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Dysbiosis of Gut Fungal Microbiota is Associated With Mucosal Inflammation in Crohn’s Disease
Open accessAbstract
GOALS: We aim to characterize the fungal microbiota in the intestinal mucosa and feces in patients with Crohn's disease (CD). BACKGROUND: Fungi represent a diverse microbial community in the human intestine and might play a role in the pathogenesis of CD; however, little is known about the structure and composition of the fungal microbiota especially adhering to the intestinal mucosa in CD patient. STUDY: Nineteen patients with active CD and 7 healthy individuals were recruited in this study. The mucosa-associated and fecal fungal microbiotas in CD patients were analyzed using culture-independent community fingerprint techniques. RESULTS: The fungal richness and diversity were significantly elevated in the inflamed mucosa compared with the noninflamed mucosa. The predominant fungal composition in the inflamed mucosa was strikingly altered, mainly characterized by expansion in the proportions of Candida spp., Gibberella moniliformis, Alternaria brassicicola, and Cryptococcus neoformans. The fecal fungal community was perturbed in CD patients as accompanied by increased fungal diversity and prevalence in Candida albicans, Aspergillus clavatus, and C. neoformans. The species richness and diversity of the mucosal fungal community were associated with the expression of TNF-α, IFN-γ, or IL-10 (P<0.05). The diversity of the fecal fungal microbiota positively correlated with serum C-reactive protein and CD activity index (P<0.05). CONCLUSIONS: This study first demonstrates that the fungal microbiota in the inflamed mucosa is distinguishable from that of the noninflamed area. Shifts of gut fungal microbiota composition may be associated with mucosal inflammation and disease activity of CD. Our data would provide novel insights into understanding the potential of gut fungal microbiota in the pathogenesis of CD.
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Cites
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New evidences on the altered gut microbiota in autism spectrum disorders
Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Renzi, D., Calabrò, A., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0242-1 · Cited by 1,040
Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer
Coker, O. O., Nakatsu, G., Dai, R. Z., Wu, W. K. K., Wong, S. H., Ng, S. C., Chan, F. K. L., Sung, J. J. Y., & Yu, J. (2019) · Gut · doi:10.1136/gutjnl-2018-317178 · Cited by 511
Gut Mycobiota in Immunity and Inflammatory Disease
Li, X. V., Leonardi, I., & Iliev, I. D. (2019) · Immunity · doi:10.1016/j.immuni.2019.05.023 · Cited by 246
The microbiota in inflammatory bowel disease: Current and therapeutic insights
Lane, E. R., Zisman, T., & Suskind, D. (2017) · Journal of Inflammation Research · doi:10.2147/jir.s116088 · Cited by 226
The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders
Hughes, H. K., Rose, D., & Ashwood, P. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0887-6 · Cited by 225
Candida albicans at Host Barrier Sites: Pattern Recognition Receptors and Beyond
Swidergall, M. (2019) · Pathogens · doi:10.3390/pathogens8010040 · Cited by 59
Choteau, L., Vancraeyneste, H., Le Roy, D., Dubuquoy, L., Romani, L., Jouault, T., Poulain, D., Sendid, B., Calandra, T., Roger, T., et al. (2017) · Gut Pathogens · doi:10.1186/s13099-017-0158-0 · Cited by 59
C-type lectin receptor-mediated immune recognition and response of the microbiota in the gut
Li, T.-H., Liu, L., Hou, Y.-Y., Shen, S.-N., & Wang, T.-T. (2019) · Gastroenterology Report · doi:10.1093/gastro/goz028 · Cited by 58
The cross-talk between opportunistic fungi and the mammalian host via microbiota’s metabolism
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The Human Gut Microbiome in Liver Diseases
Davis, B., & Bajaj, J. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1602763 · Cited by 34
Metadata
- Authors
- Li, Q., Wang, C., Tang, C., He, Q., Li, N., & Li, J.
- Venue
- Journal of Clinical Gastroenterology
- Published
- 2014-07
- Volume
- 48
- Issue
- 6
- Pages
- 513-523
- ISSN
- 0192-0790 (ISSN-L)
- OpenAlex
- W2158379634
- Cited by
- 279
- References
- 6
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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