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Lactobacillus Bacteremia Associated With Probiotic Use in a Pediatric Patient With Ulcerative Colitis
Abstract
Probiotic strains of Lactobacillus are currently used in a variety of clinical practices with limited evidence to support their use. Lactobacillus species are a normal part of gastrointestinal flora, and bacteremia with probiotic strains of Lactobacillus is very uncommon. We describe a case of Lactobacillus bacteremia in a 17-year-old boy with ulcerative colitis managed with systemic corticosteroids and infliximab, who presented with fever to 102°F, flushing, and chills 1 week after starting Lactobacillus rhamnosus GG probiotics. Initial blood culture on day 2 of his fever was positive for Lactobacillus, however, subsequent blood cultures on day 3 and 5 were negative. He was treated empirically with antibiotics for 5 days and defervesced by day 8 of his illness. 16 S rRNA sequence analysis identified the organism from the patient's blood culture and probiotic capsule as L. rhamnosus with a 99.78% match for both the strains. This case report highlights the potential risk of Lactobacillus bacteremia in immunosuppressed patients with severe active ulcerative colitis.
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“Our review of the literature (from 1980 to 2023) found 23 cases where the blood isolate from a bacteremic patient was identical to the probiotic strain the patient had been taking.”
From Lactobacillus Bacteremia and Probiotics: A Review (2023) · cites this paper as [58]
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“AEs include life-threatening pneumonia,106 endocarditis,107–111 and sepsis.112–115”
From Emerging issues in probiotic safety: 2023 perspectives (2023) · cites this paper as [114]
Citations
Cites
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
Kalliomäki, M. A., Salminen, S., Arvilommi, H. S., Kero, P. O., Koskinen, P. J., & Isolauri, E. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04259-8 · Cited by 2,443
Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial
Gionchetti, P., Rizzello, F., Helwig, U., Venturi, A., Lammers, K. M., Brigidi, P., Vitali, B., Poggioli, G., Miglioli, M., & Campieri, M. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00171-9 · Cited by 1,147
Jorgensen, J. H., & Clinical (2006) · Clinical and Laboratory Standards Institute eBooks · Cited by 1,047
VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis
Bibiloni, R., Fedorak, R. N., Tannock, G. W., Madsen, K. L., Gionchetti, P., Campieri, M., Simone, C. D., & Sartor, R. B. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41794.x · Cited by 743
Lactobacillus Sepsis Associated With Probiotic Therapy
Land, M. H., Rouster-Stevens, K., Woods, C. R., Cannon, M. L., Cnota, J., & Shetty, A. K. (2005) · Pediatrics · doi:10.1542/peds.2004-2137 · Cited by 599
LactobacillusTherapy for Acute Infectious Diarrhea in Children: A Meta-analysis
Niel, C. W. V., Feudtner, C., Garrison, M. M., & Christakis, D. (2002) · PEDIATRICS · doi:10.1542/peds.109.4.678 · Cited by 599
Venturi, Gionchetti, P., Rizzello, F., Johansson, Zucconi, Brigidi, P., Matteuzzi, & Campieri, M. (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.00560.x · Cited by 567
Miele, E., Pascarella, F., Giannetti, E., Quaglietta, L., Baldassano, R. N., & Staiano, A. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.118 · Cited by 517
Consensus guidelines for appropriate use and evaluation of microbial epidemiologic typing systems
Struelens, M. J. (1996) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.1996.tb00193.x · Cited by 458
Immunomodulatory mechanisms of lactobacilli
Wells, J. M. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-s1-s17 · Cited by 449
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- Majcher-Peszynska, 1999, Persistent Lactobacillus casei subspecies rahmnosus bacteremia in 14 year old girl with acute myeloid leukemia. A case report., Clin Pediatr, 211, 53
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Metadata
- Authors
- Vahabnezhad, E., Mochon, A. B., Wozniak, L. J., & Ziring, D. A.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Vahabnezhad, Elaheh
- Wozniak, Laura Joyce
- Ziring, David Alexander
- Venue
- Journal of Clinical Gastroenterology
- Published
- 2013-05
- Volume
- 47
- Issue
- 5
- Pages
- 437-439
- ISSN
- 0192-0790 (ISSN-L)
- OpenAlex
- W2005788065
- Cited by
- 156
- References
- 22
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 14 · 2023: 13 · 2022: 13 · 2021: 17 · 2020: 15 · 2019: 8 · 2018: 13 · 2017: 12 · 2016: 10 · 2015: 7 · 2014: 7 · 2013: 9
- FWCI
- 16.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Lactobacillus rhamnosus GG, probiotics, ulcerative colitis, pediatric patients, immunosuppression, infliximab, corticosteroids, 16S rRNA gene sequencing, blood culture contamination, antibiotic therapy
- MeSH terms
- Anti-Bacterial Agents, Colitis, Ulcerative, Humans, Male, Risk Factors, RNA, Ribosomal, 16S, Bacteremia, Immunocompromised Host, Gram-Positive Bacterial Infections, Sequence Analysis, DNA, Probiotics, Lacticaseibacillus rhamnosus
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