Cited by 1,147Inflammatory Bowel DiseaseProbiotics and Fermented FoodsGut microbiota and health

Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial

Gionchetti, Paolo, Rizzello, Fernando, Helwig, Ulf, Venturi, Alessandro, Lammers, Karen Manon, Brigidi, Patrizia, Vitali, Beatrice, Poggioli, Gilberto +2 more·2003·Gastroenterology

Abstract

Background & aims We have recently documented the efficacy of a highly concentrated probiotic preparation (VSL#3) in the prevention of flare-up in patients with chronic pouchitis. The aim of this study was to compare probiotic therapy with VSL#3 versus placebo in the ability to prevent the onset of acute pouchitis during the first year after ileal pouch-anal anastomosis.Methods Forty consecutive patients who underwent ileal pouch-anal anastomosis for ulcerative colitis were randomized to receive either VSL#3 (1 packet containing 900 billion bacteria/day) (n = 20) or an identical placebo (n = 20) immediately after ileostomy closure for 1 year. The patients were assessed clinically, endoscopically, and histologically after 1, 3, 6, 9, and 12 months. Health-related quality of life was assessed using the Inflammatory Bowel Disease Questionnaire.Results Two of the 20 patients (10%) treated with VSL#3 had an episode of acute pouchitis compared with 8 of the 20 patients (40%) treated with placebo (log-rank test, z = 2.273; P < 0.05). Treatment with VSL#3 determined a significant improvement in Inflammatory Bowel Disease Questionnaire score, whereas this was not the case with placebo.Conclusions Treatment with VSL#3 is effective in the prevention of the onset of acute pouchitis and improves quality of life of patients with ileal pouch-anal anastomosis.

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Crossref · 10.1016/s0016-5085(03)00171-9

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  • VSL#3 reduced the risk of disease onset and maintained an antibiotic-induced disease remission in pouchitis.

    “VSL#3 reduced the risk of disease onset and maintained an antibiotic-induced disease remission in pouchitis.81”

    From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [81]

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Authors
Gionchetti, P., Rizzello, F., Helwig, U., Venturi, A., Lammers, K. M., Brigidi, P., Vitali, B., Poggioli, G., Miglioli, M., & Campieri, M.
Affiliations
University of Bologna (IT)
Corresponding author
Gionchetti, Paolo
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2003-05
Volume
124
Issue
5
Pages
1202-1209
ISSN
0016-5085 (ISSN-L)
OpenAlex
W2153551892
Cited by
1,147
References
41
Citations by year
2026: 13 · 2025: 17 · 2024: 19 · 2023: 19 · 2022: 22 · 2021: 31 · 2020: 35 · 2019: 37 · 2018: 37 · 2017: 43 · 2016: 34 · 2015: 50 · 2014: 65 · 2013: 49 · 2012: 39
FWCI
47.82
Type
journal article
Language
en
Open access
closed
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
pouchitis, VSL#3, probiotics, ileal pouch-anal anastomosis, ulcerative colitis, ileostomy closure, health-related quality of life, inflammatory bowel disease
MeSH terms
Acute Disease, Adolescent, Adult, Aged, Chronic Disease, Colitis, Ulcerative, Defecation, Double-Blind Method, Enterobacteriaceae, Female, Humans, Intestines, Male, Middle Aged, Postoperative Complications, Quality of Life, Treatment Outcome, Patient Selection, Pouchitis, Probiotics

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