The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Lactobacillus Bacteremia Associated With Probiotic Use in a Pediatric Patient With Ulcerative Colitis
Abstract
Probiotic strains of Lactobacillus are currently used in a variety of clinical practices with limited evidence to support their use. Lactobacillus species are a normal part of gastrointestinal flora, and bacteremia with probiotic strains of Lactobacillus is very uncommon. We describe a case of Lactobacillus bacteremia in a 17-year-old boy with ulcerative colitis managed with systemic corticosteroids and infliximab, who presented with fever to 102°F, flushing, and chills 1 week after starting Lactobacillus rhamnosus GG probiotics. Initial blood culture on day 2 of his fever was positive for Lactobacillus, however, subsequent blood cultures on day 3 and 5 were negative. He was treated empirically with antibiotics for 5 days and defervesced by day 8 of his illness. 16 S rRNA sequence analysis identified the organism from the patient's blood culture and probiotic capsule as L. rhamnosus with a 99.78% match for both the strains. This case report highlights the potential risk of Lactobacillus bacteremia in immunosuppressed patients with severe active ulcerative colitis.
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“Our review of the literature (from 1980 to 2023) found 23 cases where the blood isolate from a bacteremic patient was identical to the probiotic strain the patient had been taking.”
From Lactobacillus Bacteremia and Probiotics: A Review (2023) · cites this paper as [58]
In the citing paper
“AEs include life-threatening pneumonia,106 endocarditis,107–111 and sepsis.112–115”
From Emerging issues in probiotic safety: 2023 perspectives (2023) · cites this paper as [114]
Citations
Cites
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
Kalliomäki, M. A., Salminen, S., Arvilommi, H. S., Kero, P. O., Koskinen, P. J., & Isolauri, E. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04259-8 · Cited by 2,443
Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial
Gionchetti, P., Rizzello, F., Helwig, U., Venturi, A., Lammers, K. M., Brigidi, P., Vitali, B., Poggioli, G., Miglioli, M., & Campieri, M. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00171-9 · Cited by 1,147
Jorgensen, J. H., & Clinical (2006) · Clinical and Laboratory Standards Institute eBooks · Cited by 1,047
VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis
Bibiloni, R., Fedorak, R. N., Tannock, G. W., Madsen, K. L., Gionchetti, P., Campieri, M., Simone, C. D., & Sartor, R. B. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41794.x · Cited by 743
Lactobacillus Sepsis Associated With Probiotic Therapy
Land, M. H., Rouster-Stevens, K., Woods, C. R., Cannon, M. L., Cnota, J., & Shetty, A. K. (2005) · Pediatrics · doi:10.1542/peds.2004-2137 · Cited by 599
LactobacillusTherapy for Acute Infectious Diarrhea in Children: A Meta-analysis
Niel, C. W. V., Feudtner, C., Garrison, M. M., & Christakis, D. (2002) · PEDIATRICS · doi:10.1542/peds.109.4.678 · Cited by 599
Venturi, Gionchetti, P., Rizzello, F., Johansson, Zucconi, Brigidi, P., Matteuzzi, & Campieri, M. (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.00560.x · Cited by 567
Miele, E., Pascarella, F., Giannetti, E., Quaglietta, L., Baldassano, R. N., & Staiano, A. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.118 · Cited by 517
Consensus guidelines for appropriate use and evaluation of microbial epidemiologic typing systems
Struelens, M. J. (1996) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.1996.tb00193.x · Cited by 458
Immunomodulatory mechanisms of lactobacilli
Wells, J. M. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-s1-s17 · Cited by 449
Lactic acid bacteria and human clinical infection
Aguirre, M., & Collins, M. D. (1993) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1993.tb02753.x · Cited by 425
Vanderpool, C., Yan, F., & Polk, B. D. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20525 · Cited by 340
Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora
Reid, G., Beuerman, D., Heinemann, C., & Bruce, A. W. (2001) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2001.tb00531.x · Cited by 328
Liver Abscess Due to aLactobacillus rhamnosusStrain Indistinguishable fromL. rhamnosusStrain GG
Rautio, M., Jousimies-Somer, H. R., Kauma, H., Pietarinen, I., Saxelin, M., Tynkkynen, S., & Koskela, M. (1999) · Clinical Infectious Diseases · doi:10.1086/514766 · Cited by 327
Lactobacillus endocarditis caused by a probiotic organism
Mackay, A. D., Taylor, M. B., Kibbler, C. C., & Hamilton-Miller, J. M. T. (1999) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.1999.tb00144.x · Cited by 264
Woo, P. C. Y., Ng, K. H. L., Lau, S. K. P., Yip, K.-T., Fung, A. M. Y., Leung, K.-W., Tam, D. M. W., Que, T., & Yuen, K. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.5.1996-2001.2003 · Cited by 205
Huynh, H. Q., deBruyn, J. C. C., Guan, L. L., Díaz, H., Li, M., Girgis, S., Turner, J. M., Fedorak, R. N., & Madsen, K. L. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20816 · Cited by 147
Lactobacillemia in liver transplant patients
Patel, R., Cockerill, F. R., Porayko, M. K., Osmon, D. R., Ilstrup, D. M., & Keating, M. R. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/18.2.207 · Cited by 100
Indigenous and pathogenic microorganisms of humans.
Isenberg, H. D., Painter, B., Lennette, E. H., Balows, A., Hausler, W. J., & Truant, J. P. (1980) · Cited by 74
Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory Pathways
Yoon, S. S., & Sun, J. (2011) · Gastroenterology Research and Practice · doi:10.1155/2011/971938 · Cited by 67
Lactobacillus casei subsp. rhamnosus Sepsis in a Patient With Ulcerative Colitis
Farina, C., Arosio, M. E. G., Mangia, M., & Moioli, F. (2001) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200109000-00019 · Cited by 65
The Rationale and Clinical Effectiveness of Probiotics in Irritable Bowel Syndrome
Ringel, Y., & Ringel-Kulka, T. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31822d32d3 · Cited by 44
Flagged first, then by citations
Research works printed but not linked: 1
- Majcher-Peszynska, 1999, Persistent Lactobacillus casei subspecies rahmnosus bacteremia in 14 year old girl with acute myeloid leukemia. A case report., Clin Pediatr, 211, 53
Cited by
Sorted by citations
Doron, S., & Snydman, D. R. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ085 · Cited by 942
ESPEN guideline: Clinical nutrition in inflammatory bowel disease
Forbes, A., Escher, J., Hébuterne, X., Kłęk, S., Krznaric, Z., Schneider, S., Shamir, R., Stardelova, K., Wierdsma, N., Wiskin, A. E., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.12.027 · Cited by 625
RetractedEmerging issues in probiotic safety: 2023 perspectives
Merenstein, D., Pot, B., Leyer, G., Ouwehand, A. C., Preidis, G. A., Elkins, C. A., Hill, C., Lewis, Z. T., Shane, A. L., Zmora, N., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2185034 · Cited by 481
(BIOHAZ), E. P. O. B. H., Ricci, A., Allende, A., Bolton, D., Chemaly, M., Davies, R., Gironés, R., Herman, L., Koutsoumanis, K. P., Lindqvist, R., et al. (2017) · EFSA Journal · doi:10.2903/j.efsa.2017.4664 · Cited by 467
Probiotic supplements might not be universally-effective and safe: A review
Kothari, D., Patel, S., & Kim, S.-K. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.104 · Cited by 445
Metadata
- Authors
- Vahabnezhad, E., Mochon, A. B., Wozniak, L. J., & Ziring, D. A.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Vahabnezhad, Elaheh
- Wozniak, Laura Joyce
- Ziring, David Alexander
- Venue
- Journal of Clinical Gastroenterology
- Published
- 2013-05
- Volume
- 47
- Issue
- 5
- Pages
- 437-439
- ISSN
- 0192-0790 (ISSN-L)
- OpenAlex
- W2005788065
- Cited by
- 156
- References
- 22
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 14 · 2023: 13 · 2022: 13 · 2021: 17 · 2020: 15 · 2019: 8 · 2018: 13 · 2017: 12 · 2016: 10 · 2015: 7 · 2014: 7 · 2013: 9
- FWCI
- 16.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Lactobacillus rhamnosus GG, probiotics, ulcerative colitis, pediatric patients, immunosuppression, infliximab, corticosteroids, 16S rRNA gene sequencing, blood culture contamination, antibiotic therapy
- MeSH terms
- Anti-Bacterial Agents, Colitis, Ulcerative, Humans, Male, Risk Factors, RNA, Ribosomal, 16S, Bacteremia, Immunocompromised Host, Gram-Positive Bacterial Infections, Sequence Analysis, DNA, Probiotics, Lacticaseibacillus rhamnosus
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