Cited by 110Asthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) ResearchChronic Disease Management Strategies

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Prevalence of Comorbidities in Asthma and Nonasthma Patients: A Meta-analysis

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Su, Xinming, Ren, Yuan, Li, Menglu, Zhao, Xuan, Kong, Lingfei, Kang, Jian·2016·Medicine

DOI 10.1097/md.0000000000003459PMC PMC4900697

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Abstract

This study compares the prevalence rates of comorbidities between asthma and nonasthma control patients reported in the literature.Literature was searched in several electronic databases. After the selection of studies by following précised eligibility criteria, meta-analyses of odds ratios were carried out with subgroup and sensitivity analyses.Eleven studies studying 117,548 asthma patients compared with 443,948 non-asthma controls were included in the meta-analysis. The prevalence of cardiovascular comorbidities (odds ratio (OR): [95% CI] 1.90 [1.70, 2.14]; P < 0.00001), cerebrovascular comorbidities (OR 1.44 [1.29, 1.60]; P < 0.00001), obesity (OR 1.51 [1.14, 2.01]; P < 0.00001), hypertension (OR 1.66 [1.47, 1.88]; P < 0.00001, diabetes (OR 1.25 [1.08, 1.44]; P < 0.00001), other metabolic and endocrine comorbidities (OR 1.60 [1.40, 1.83]; P < 0.00001), psychiatric and neurological comorbidities (OR 1.62 [1.44, 1.82]; P < 0.00001), gut and urinary comorbidities (OR 1.91 [1.47, 2.49]; P < 0.00001),), cancer (OR 1.17 [1.10, 1.25]; P < 0.00001), and respiratory comorbidities (OR 5.60 [4.22, 7.44]; P < 0.00001) were significantly higher in the asthma patients in comparison with nonasthma controls.Asthma is associated with significantly higher comorbidities including cardio-/cerebrovascular diseases, obesity, hypertension, diabetes, psychiatric and neurological comorbidities, gut and urinary conditions, cancer, and respiratory problems other than asthma. Respiratory comorbidities are found 5 times more prevalent in asthma than in non-asthma patients.

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FIGURE 1 A flowchart of the literature search, study screening, and selection process.CC BY · PubMed Central

FIGURE 2 A funnel plot of the overall meta-analysis of metabolic and endocrine comorbidities reflecting publication bias.CC BY · PubMed Central

FIGURE 3 Forest plots showing significantly higher prevalence of cardiovascular and cerebrovascular comorbidities in asthma patients. CAD = coronary artery disease, CeVD = cerebrovascular disease, CHD = coronary heart disease, CHF = congestive heart failure, Cong. HD = congenital heart disease, CVD = cardiovascular disease, dis = disease/disorder, MI = myocardial infarction.CC BY · PubMed Central

FIGURE 4 Forest plots showing significantly higher prevalence of metabolic comorbidities in asthma patients. dis. = disease/disorder, DYSLIP = dyslipidemia, HYPLIP = hyperlipidemia, THY = thyroid.CC BY · PubMed Central

FIGURE 5 Forest plots showing significantly higher prevalence of neurological and psychiatric comorbidities in asthma patients. ANX = anxiety, COGN = cognitive impairment, DEM = dementia, DEP = depression, dis. = disease/disorder.CC BY · PubMed Central

FIGURE 6 Forest plots showing significantly higher prevalence of gastrointestinal and urinary comorbidities in asthma patients. dis = disease/disorder, GERD = gastro-esophageal reflex disease.CC BY · PubMed Central

FIGURE 7 Forest plots showing significantly higher prevalence of respiratory comorbidities in asthma patients. Bronch = bronchitis, ch = chronic, COPD = chronic obstructive pulmonary disease, Infect = infection/s, Resp = respiratory.CC BY · PubMed Central

FIGURE 8 Forest plots showing significantly higher prevalence of cancer and other comorbidities in asthma patients. However, the prevalence of arthritis was not significantly different between asthma and nonasthma patients.CC BY · PubMed Central

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Authors: Su, X., Ren, Y., Li, M., Zhao, X., Kong, L., & Kang, J.
Affiliations: First Hospital of China Medical University (CN)
Corresponding author: Su, Xinming
ORCID: Su, Xinming
Ren, Yuan
Li, Menglu
Zhao, Xuan
Kong, Lingfei
Kang, Jian
Venue: Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2016-05
Volume: 95
Issue: 22
Pages: e3459
ISSN: 0025-7974 (ISSN-L)
DOI: 10.1097/md.0000000000003459
PMC: PMC4900697
OpenAlex: W2411471160
Cited by: 110
References: 37
Citations by year: 2026: 8 · 2025: 4 · 2024: 14 · 2023: 15 · 2022: 10 · 2021: 15 · 2020: 11 · 2019: 18 · 2018: 10 · 2017: 5
FWCI: 1.29
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Medicine (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (2013225049, 81300024)
Department of Science and Technology of Liaoning Province (2013225049)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
Keywords: asthma, comorbidities, cardiovascular comorbidity, obesity, hypertension, diabetes mellitus, psychiatric comorbidity, neurological comorbidity, respiratory comorbidities, cancer, prevalence, chronic disease burden, comorbidity risk factors
MeSH terms: Asthma, Cardiovascular Diseases, Cerebrovascular Disorders, Endocrine System Diseases, Humans, Global Health, Comorbidity, Prevalence

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Prevalence of Comorbidities in Asthma and Nonasthma Patients: A Meta-analysis

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