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The effect of sex hormones on normal breast tissue metabolism: Evaluation by FDG PET/CT
Open accessAbstract
This study investigated the effect of sex hormones on 18 F-fluorodeoxyglucose (FDG) uptake in normal breast tissue. The retrospective study included 249 premenopausal women (median age, 45 years) who were diagnosed with unilateral breast cancer and underwent FDG positron emission tomography/computed tomography and hormone tests. The volume of interest was within the contralateral normal breast and the standardized uptake values (SUVs) were measured. The correlations of sex hormones (including estrogen, progesterone, testosterone, follicle-stimulating hormone [FSH] and luteinizing hormone [LH]) with the SUVs of the normal breast were analyzed. There was a weak negative correlation between age and breast FDG uptake (P = .012, Spearman coefficient = −.16 for the maximum standardized uptake values [SUVmax]), especially in the luteal phase group (P = .005, Spearman coefficient = −.27 for SUVmax). The SUVs of normal breast tissue were increased when progesterone levels were higher (P = .043, Spearman coefficient = .13 for SUVmax). In the irregular menstrual cycle group, FDG uptake in the breast decreased as FSH (P = .027, Spearman coefficient = −.42 for SUVmax) and LH (P = .048, Spearman coefficient = −.44 for SUVmax) increased. Glucose metabolism of normal breast tissue decreases with age, and progesterone weakly affects breast FDG uptake. Gonadotropins may affect breast FDG uptake in premenopausal women with irregular menstrual cycles.
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In women, [18F]FDG uptake in ovaries and breast tissue varies with progesterone levels and age.
“In women, [18F]FDG uptake in the ovaries and breast tissue varies with progesterone levels and age [11,12].”
From Influences on PET Quantification and Interpretation (2022) · cites this paper as [11]
The Results (Correlation between FDG uptake and parameters) report weak correlations between normal breast FDG uptake, progesterone levels, and age in premenopausal women. The paper does not report FDG uptake in the ovaries, so it does not support that part of the sentence. (LLM, conf=0.88)
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Developing dietary interventions as therapy for cancer
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Metadata
- Authors
- Jung, Y., Kim, T. H., Kim, J. Y., Han, S., & An, Y.-S.
- Affiliations
- Department of Surgery
- Department of Radiology
- Ajou University (KR)
- Corresponding author
- An, Young-Sil
- Venue
- Medicine
- Published
- 2019-07
- Volume
- 98
- Issue
- 27
- Pages
- e16306
- ISSN
- 0025-7974 (ISSN-L)
- 1536-5964
- PMC
- PMC6635257
- OpenAlex
- W2960507127
- Cited by
- 7
- References
- 34
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 5
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Medicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- AJOU Open Repository (Ajou University) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- sex hormones, normal breast tissue, FDG uptake, progesterone, follicle-stimulating hormone, luteinizing hormone, gonadotropins, menstrual cycle, luteal phase, premenopausal women, standardized uptake value, breast cancer
- MeSH terms
- Positron Emission Tomography Computed Tomography, Adult, Breast, Breast Neoplasms, Estradiol, Female, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Middle Aged, Progesterone, Reference Values, Retrospective Studies, Testosterone, Radiopharmaceuticals, Fluorodeoxyglucose F18
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