Stromal cell-derived factor-1 as a serologic biomarker for the diagnosis of colon ischemia with chronic cardiovascular disease
Open accessAbstract
Colon ischemia (CI) is the most common ischemic disorder of the gastrointestinal tract. Although some markers of CI, such as procalcitonin and alkaline phosphatase, have been reported, few specific serum markers have been identified. We investigated whether serum stromal cell-derived factor-1 (SDF-1) is a specific marker of CI and clarified the relationship between serum SDF-1 level and CI according to a history of combined chronic cardiovascular disease (CVD). We measured SDF-1 level and other serological markers in 84 patients (control, n = 20; CI without chronic CVD, n = 21; chronic CVD without CI, n = 20; CI with chronic CVD, n = 23). Patients with CI were older than those without CI. There were more women in the CI groups than those without CI. At admission, SDF-1 level was significantly higher in patients having CI with chronic CVD (P < .001) than in other groups. SDF-1 level was significantly higher at admission than at discharge in patients having CI with chronic CVD (P < .001) but not in patients having CI without chronic CVD. SDF-1 level did not differ according to symptoms, involved sites, or duration of hospitalization. At a cutoff value of 0.5 pg/mL for the SDF-1 level in patients having CI with chronic CVD, the sensitivity and specificity for SDF-1 were 91.3% and 95%, respectively. The area-under-the-curve (AUC) value was 0.95. In the logistic regression analysis, an elevation of the SDF-1 level to >0.5 pg/mL was a significant indicator of CI with chronic CVD [odds ratio (OR), 114.914; 95% confidence interval, 10.51 to >999.999; P < .001]. SDF-1 could be a useful early biomarker for the diagnosis of CI in patients with chronic CVD.
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Stromal cell-derived factor-1 had sensitivity 91% and specificity 95% in a single study.
“Stromal cell-derived factor-1 (SDF-1) (sensitivity and specificity 91 and 95%, respectively) [86].”
From Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis (2023) · cites this paper as [86]
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“These biomarkers were: Stromal cell-derived factor-1 (SDF-1) (sensitivity and specificity 91 and 95%, respectively) [86].”
Background
- Authors
- Kim, K. Y., Lee, H. K., Kim, H., Kim, Y., Kim, Y., Choi, H. H., Kim, S. W., Kim, H. K., & Chae, H. S.
- Affiliations
- The Catholic University of Korea Uijeongbu St. Mary's Hospital (KR)
- Department of Laboratory Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
- Corresponding author
- Chae, Hiun Suk
- ORCID
- Venue
- Medicine
- Published
- 2020-06-05
- Volume
- 99
- Issue
- 23
- Pages
- e20539
- ISSN
- 0025-7974 (ISSN-L)
- 1536-5964
- PMC
- PMC7306348
- OpenAlex
- W3033968222
- Cited by
- 7
- References
- 36
- Citations by year
- 2024: 4 · 2023: 1 · 2022: 2
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Medicine (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Research Foundation
- Catholic University of Korea
- National Research Foundation of Korea
- College of Medicine, Catholic University of Korea
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Keywords
- ischemic colitis, CXCL12, serum biomarkers, chronic cardiovascular disease, early diagnosis, procalcitonin, alkaline phosphatase, sensitivity and specificity
- MeSH terms
- Aged, Alkaline Phosphatase, Cardiovascular Diseases, Chronic Disease, Colon, Creatine Kinase, Female, Humans, Ischemia, L-Lactate Dehydrogenase, Male, Middle Aged, Sensitivity and Specificity, Biomarkers, Case-Control Studies, Chemokine CXCL12
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