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Cited by 16Fibromyalgia and Chronic Fatigue Syndrome ResearchDiabetes, Cardiovascular Risks, and LipoproteinsFibroblast Growth Factor Research

Glucose tolerance in fibromyalgia

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Zetterman, Teemu, Markkula, Ritva, Kalso, Eija·2021·Medicine
DOI 10.1097/md.0000000000027803PMC PMC8601335
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Abstract

Objectives: Fibromyalgia (FM) patients have an increased risk for glucose metabolism disturbances, and impaired glucose tolerance may be associated with symptom severity. Elevated levels of plasma lactate have been detected in FM patients. Both pyruvate and lactate are produced in glucose metabolism and reflect oxidative metabolism. The objective of our study was to analyse disturbances in glucose, pyruvate, or lactate metabolism in FM patients. Methods: We measured plasma levels of glucose, pyruvate, and lactate during an oral glucose tolerance test in 40 non-diabetic, female FM patients and 30 age- and gender-matched healthy controls. Results: FM patients showed a higher glycaemic response to the glucose load at 1 hour (F [1,68] = 10.4, P = .006) and 2 hours (F [1,68] = 7.80, P = .02), and higher glucose area under the curve (13.8 [SD 2.92] vs 11.6 [SD 2.31], P < .01), than healthy controls. Group differences were explained by higher body mass index and percentage of smokers among the FM patients. Pyruvate and lactate levels were similar in both groups. Discussion: Impaired glucose regulation in FM patients is likely not due to FM itself, but to associated lifestyle factors. Our results highlight the importance of assessing the glucose regulation status and the lifestyle factors affecting glucose regulation in FM patients for prevention or early treatment of diabetes and associated complications. Trial Registration: ClinicalTrials.gov (NCT03300635)

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Cited by

Sorted by citations

Authors
Zetterman, T., Markkula, R., & Kalso, E.
Affiliations
University of Helsinki (FI)
Corresponding author
Zetterman, Teemu
ORCID
Venue
Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2021-11-19
Volume
100
Issue
46
Pages
e27803
ISSN
  • 0025-7974 (ISSN-L)
  • 1536-5964
DOI
10.1097/md.0000000000027803
PMC
PMC8601335
OpenAlex
W3212283400
Cited by
16
References
7
Citations by year
2026: 1 · 2025: 2 · 2024: 8 · 2023: 3 · 2022: 2
FWCI
2.33
Type
journal article
Language
en
Open access
Licence
Locations
  • Medicine (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Työväentutkimus Vuosikirja (submittedVersion)
Funders
finnish state research funding (TYH2017215)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Keywords
fibromyalgia, impaired glucose tolerance, glucose metabolism, plasma lactate, oral glucose tolerance test, glycemic response, body mass index, smoking, diabetes prevention, lifestyle factors
MeSH terms
Adult, Aged, Blood Glucose, Female, Fibromyalgia, Glucose, Glucose Tolerance Test, Humans, Lactates, Male, Middle Aged, Pyruvates, Case-Control Studies, Healthy Volunteers

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