Role of Sleep and Sleep Loss in Hormonal Release and Metabolism
Open accessAbstract
Compared to a few decades ago, adults, as well as children, sleep less. Sleeping as little as possible is often seen as an admirable behavior in contemporary society. However, sleep plays a major role in neuroendocrine function and glucose metabolism. Evidence that the curtailment of sleep duration may have adverse health effects has emerged in the past 10 years. Accumulating evidence from both epidemiologic studies and well-controlled laboratory studies indicates that chronic partial sleep loss may increase the risk of obesity and weight gain. The present chapter reviews epidemiologic studies in adults and children and laboratory studies in young adults indicating that sleep restriction results in metabolic and endocrine alterations, including decreased glucose tolerance, decreased insulin sensitivity, increased evening concentrations of cortisol, increased levels of ghrelin, decreased levels of leptin and increased hunger and appetite. Altogether, the evidence points to a possible role of decreased sleep duration in the current epidemic of obesity. Bedtime extension in short sleepers should be explored as a novel behavioral intervention that may prevent weight gain or facilitate weight loss. Avoiding sleep deprivation may help to prevent the development of obesity, particularly in children.
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Well-controlled laboratory studies in healthy adults have shown that repeated partial sleep restriction adversely affects systemic insulin sensitivity and glucose tolerance.
“well-controlled laboratory studies in healthy adults have shown that repeated partial sleep restriction has adverse effects on systemic insulin sensitivity and glucose tolerance”
From Impaired Insulin Signaling in Human Adipocytes After Experimental Sleep Restriction: A Randomized, Crossover Study (2012) · cites this paper as [14]
The finding identifies a molecular mechanism that may be involved in the reduction in total body insulin sensitivity observed in multiple laboratory studies of partial sleep deprivation.
“To our knowledge, this finding identifies for the first time a molecular mechanism that may be involved in the reduction in total body insulin sensitivity consistently observed in multiple laboratory studies of partial sleep deprivation in healthy adults (11–17), as well as in the participants of our study.”
From Impaired Insulin Signaling in Human Adipocytes After Experimental Sleep Restriction: A Randomized, Crossover Study (2012) · cites this paper as [14]
Insufficient sleep decreases plasma leptin levels, increases plasma ghrelin and cortisol levels, alters glucose homeostasis, and activates the orexin system, all of which affect appetite control.
“Recent studies indicate that insufficient sleep decreases plasma leptin levels, increases plasma ghrelin and cortisol levels, alters glucose homeostasis and activates the orexin system, all of which affect appetite control [104].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [104]
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- Authors
- Leproult, R., & Van Cauter, E.
- Affiliations
- University of Chicago (US)
- ORCID
- Leproult, Rachel
- Venue
- Endocrine Development
- Publisher
- S. Karger AG
- Published
- 2009-11-24
- Volume
- 17
- Pages
- 11-21
- ISSN
- 1421-7082 (ISSN-L)
- 1662-2979
- PMC
- PMC3065172
- OpenAlex
- W1673125506
- Cited by
- 602
- References
- 27
- Citations by year
- 2026: 35 · 2025: 35 · 2024: 53 · 2023: 48 · 2022: 57 · 2021: 52 · 2020: 27 · 2019: 35 · 2018: 30 · 2017: 24 · 2016: 33 · 2015: 33 · 2014: 30 · 2013: 36 · 2012: 40
- FWCI
- 91.47
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrine development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- National Institute on Aging (P01AG011412)
- National Heart, Lung, and Blood Institute (R01HL075079, R01HL075025)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK0716960, P60DK020595)
- National Center for Research Resources (M01RR000055)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep restriction, sleep deprivation, sleep duration, obesity, weight gain, glucose tolerance, insulin sensitivity, cortisol, ghrelin, leptin, appetite, hunger, neuroendocrine function, short sleepers, children
- MeSH terms
- Adolescent, Animals, Appetite, Child, Glucose, Hormones, Humans, Obesity, Sleep, Sleep Deprivation
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