CoChat
Sign Up
Cited by 234Oral microbiology and periodontitis researchDental Research and COVID-19Adipokines, Inflammation, and Metabolic Diseases

Diabetes mellitus and inflammatory periodontal diseases

Mealey, Brian L, Rose, Louis F·2008·Current Opinion in Endocrinology, Diabetes & Obesity
DOI 10.1097/med.0b013e3282f824b7
Open this paper in CoChat — free account

Abstract

PURPOSE OF REVIEW: Periodontal diseases are inflammatory conditions that were once thought to have manifestations localized to the oral cavity alone, and were therefore considered the concern of only dentists and other oral health professionals. Emerging evidence has changed this view and now suggests that periodontal diseases may play a role in numerous conditions that impact systemic well being, including diabetes mellitus. This review examines the relationships that exist between periodontal diseases and diabetes mellitus, with a focus on potential common pathophysiologic pathways including those associated with inflammation, altered host responses, and insulin resistance. RECENT FINDINGS: Periodontal inflammation is associated with an elevated systemic inflammatory state and an increased risk of major cardiovascular events such as myocardial infarction and stroke, adverse pregnancy outcomes such as preeclampsia, low birth weight and preterm birth, and altered glycemic control in people with diabetes. Intervention trials suggest that periodontal therapy, which decreases the intraoral bacterial bioburden and reduces periodontal inflammation, can have a significant impact on systemic inflammatory status. Evidence suggests that periodontal therapy is associated with improved glycemic control in many patients with both diabetes and periodontal diseases. SUMMARY: Recognition of the bilateral relationships between oral and systemic health will challenge physicians and dentists to work together closely in the future when managing patients with diabetes and periodontal disease.

Integrity signals

Registry

Crossref · 10.1097/med.0b013e3282f824b7

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Type 2 diabetes mellitus, and the hyperglycemia related to this disease, are associated with increased risk of periodontitis as a result of the vascular complications of diabetes and increased levels of pro-inflammatory molecules.

    “Type 2 diabetes mellitus, and the hyperglycemia related to this disease, are associated with increased risk of periodontitis as a result of the vascular complications of diabetes and increased levels of pro‐inflammatory molecules.216, 217, 218”

    From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [216]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Mealey, B. L., & Rose, L. F.
Affiliations
  • The University of Texas at San Antonio Health Science Center (US)
  • New York University (US)
Corresponding author
Rose, Louis F
ORCID
Venue
Current Opinion in Endocrinology, Diabetes & Obesity
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2008-04
Volume
15
Issue
2
Pages
135-141
ISSN
1752-296X (ISSN-L)
DOI
10.1097/med.0b013e3282f824b7
OpenAlex
W2037234222
Cited by
234
References
41
Citations by year
2026: 1 · 2025: 6 · 2024: 6 · 2023: 10 · 2022: 13 · 2021: 10 · 2020: 17 · 2019: 13 · 2018: 10 · 2017: 12 · 2016: 11 · 2015: 7 · 2014: 20 · 2013: 13 · 2012: 32
FWCI
2.53
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Endocrinology Diabetes and Obesity (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
diabetes mellitus, periodontal disease, periodontitis, periodontal treatment, systemic inflammation, insulin resistance, glycemic control, cardiovascular risk, preeclampsia, preterm birth, low birth weight, oral-systemic health, host response
MeSH terms
Bacterial Infections, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Gingiva, Humans, Inflammation, Insulin Resistance, Periodontitis, Disease Progression, Diabetes Complications

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review