Subgingival biodiversity in subjects with uncontrolled type‐2 diabetes and chronic periodontitis
Abstract
Background and Objective: There is a bidirectional relationship between periodontal disease and type‐2 diabetes mellitus (DM). Inflammatory mediators may negatively affect glycemic control, and increased glucose levels and resultant glycation end‐products may alter the host response against bacterial infection. However, no agreement has been reached regarding the effect of DM on periodontal subgingival microbiota. Therefore, the purpose of the present study was to compare the subgingival biodiversity in deep periodontal pockets of subjects with chronic periodontitis and either uncontrolled type‐2 diabetes or no diabetes using 16S rRNA gene cloning and sequencing. Material and methods: Twelve subjects with uncontrolled type‐2 diabetes (glycated hemoglobin > 8%) and eleven nondiabetic subjects presenting severe and generalized chronic periodontitis were selected. Subgingival biofilm from periodontal pockets > 5 mm were assessed using the 16S rRNA gene cloning and sequencing technique. Results: Significant differences were observed in subgingival microbiota between diabetic and nondiabetic subjects. Diabetic subjects presented higher percentages of total clones of TM7, Aggregatibacter, Neisseria, Gemella, Eikenella, Selenomonas, Actinomyces, Capnocytophaga, Fusobacterium, Veillonella and Streptococcus genera, and lower percentages of Porphyromonas, Filifactor, Eubacterium, Synergistetes, Tannerella and Treponema genera than nondiabetic individuals (p < 0.05). Moreover, some phylotypes, such as Fusobacterium nucleatum, Veillonella parvula, V. dispar and Eikenella corrodens were detected significantly more often in diabetic subjects than in nondiabetic subjects (p < 0.05). Conclusion: Subjects with uncontrolled type‐2 diabetes and chronic periodontitis presented significant dissimilarities in subgingival biodiversity compared with nondiabetic subjects.
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Differences in the composition of subgingival plaque have been found among patients with periodontitis, with or without type 2 diabetes; specifically, patients with diabetes harbor higher proportions of Capnocytophaga species, F nucleatum, Eikenella corrodens, and A actinomycetemcomitans than patients without diabetes.
“Differences in the composition of subgingival plaque have been found among patients with periodontitis, with or without type 2 diabetes; specifically, patients with diabetes harbor higher proportions of Capnocytophaga species, F nucleatum, Eikenella corrodens, and A actinomycetemcomitans than patients without diabetes.219”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [219]
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- Authors
- Casarin, R. C. V., Barbagallo, A., Meulman, T., Santos, V. R., Sallum, E. A., Nociti, F. H., Duarte, P. M., Casati, M. Z., & Gonçalves, R. B.
- Affiliations
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Université Laval (CA)
- Guarulhos University (BR)
- Corresponding author
- Casarin, R. C. V.
- Venue
- Journal of Periodontal Research
- Publisher
- Wiley
- Published
- 2012-07-04
- Volume
- 48
- Issue
- 1
- Pages
- 30-36
- ISSN
- 0022-3484 (ISSN-L)
- 1600-0765
- OpenAlex
- W2149358775
- Cited by
- 256
- References
- 42
- Citations by year
- 2026: 9 · 2025: 25 · 2024: 30 · 2023: 25 · 2022: 33 · 2021: 23 · 2020: 28 · 2019: 15 · 2018: 18 · 2017: 17 · 2016: 6 · 2015: 9 · 2014: 13 · 2013: 2 · 2012: 3
- FWCI
- 10.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Periodontal Research (publishedVersion)
- PubMed (publishedVersion)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
- UNESP Institutional Repository (São Paulo State University) (submittedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
- Keywords
- type 2 diabetes, chronic periodontitis, subgingival microbiota, periodontal pockets, subgingival plaque, Fusobacterium nucleatum, Veillonella, Eikenella corrodens, Porphyromonas, Aggregatibacter, TM7, glycemic control
- MeSH terms
- Actinobacillus, Actinomyces, Adult, Bacteria, Bacteroides, Capnocytophaga, Diabetes Mellitus, Type 2, Eubacterium, Female, Fusobacterium, Gingiva, Gram-Negative Anaerobic Bacteria, Humans, Male, Neisseria, Periodontal Pocket, RNA, Bacterial, RNA, Ribosomal, 16S, Streptococcus, Treponema, Veillonella, Eikenella, Periodontal Attachment Loss, Porphyromonas, Biofilms, Selenomonas, Biodiversity, Chronic Periodontitis, Gemella
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