Placental hormones and the control of maternal metabolism and fetal growth

Effect of In Utero and Early-Life Conditions on Adult Health and Disease

Gluckman, P. D., Hanson, M. A., Cooper, C., & Thornburg, K. L. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0708473 · Cited by 3,898

Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans

Masuzaki, H., Ogawa, Y., Sagawa, N., Hosoda, K., Matsumoto, T., Mise, H., Nishimura, H., Yoshimasa, Y., Tanaka, I., Mori, T., et al. (1997) · Nature Medicine · doi:10.1038/nm0997-1029 · Cited by 1,277

Cellular Mechanisms for Insulin Resistance in Normal Pregnancy and Gestational Diabetes

Barbour, L. A., McCurdy, C. E., Hernandez, T. L., Kirwan, J. P., Catalano, P. M., & Friedman, J. E. (2007) · Diabetes Care · doi:10.2337/dc07-s202 · Cited by 811

TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy

Kirwan, J. P., Hauguel-De Mouzon, S., Lepercq, J., Challier, J.-C., Huston-Presley, L., Friedman, J. E., Kalhan, S. C., & Catalano, P. M. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2207 · Cited by 738

Pregnancy-Stimulated Neurogenesis in the Adult Female Forebrain Mediated by Prolactin

Shingo, T., Gregg, C., Enwere, E. K., Fujikawa, H., Hassam, R., Geary, C. L., Cross, J. C., & Weiss, S. (2003) · Science · doi:10.1126/science.1076647 · Cited by 711

β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans

Meier, J. J., Butler, A. E., Saisho, Y., Monchamp, T., Galasso, R., Bhushan, A., Rizza, R. A., & Butler, P. C. (2008) · Diabetes · doi:10.2337/db07-1369 · Cited by 683

Endocrine Regulation of Human Fetal Growth: The Role of the Mother, Placenta, and Fetus

Murphy, V. E., Smith, R., Giles, W. B., & Clifton, V. L. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0011 · Cited by 673

Maternal and Fetal Hypothalamic‐Pituitary‐Adrenal Axes During Pregnancy and Postpartum

MASTORAKOS, G., & ILIAS, I. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1290.016 · Cited by 621

β cell replication is the primary mechanism for maintaining postnatal β cell mass

Georgia, S. K., & Bhushan, A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22098 · Cited by 510

Role of Gestational Hormones in the Induction of Insulin Resistance*

Ryan, E. A., & Enns, L. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-2-341 · Cited by 401

Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth

Kushner, J. A., Ciemerych, M. A., Sicinska, E., Wartschow, L. M., Teta, M., Long, S. Y., Sicinski, P., & White, M. F. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.9.3752-3762.2005 · Cited by 334

Progesterone and the immunology of pregnancy

Druckmann, R. A., & Druckmann, M.-A. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.08.010 · Cited by 312

Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy

Highman, T. J., Friedman, J. E., Huston, L. P., Wong, W. W., & Catalano, P. M. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70540-x · Cited by 277

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism

Catalano, P. M., Hoegh, A. M., Minium, J., Huston-Presley, L., Bernard, S. L., Kalhan, S. C., & Mouzon, S. H. (2006) · Diabetologia · doi:10.1007/s00125-006-0264-x · Cited by 275

Prolactin Receptor Is Required for Normal Glucose Homeostasis and Modulation of β-Cell Mass during Pregnancy

Huang, C., Snider, F., & Cross, J. C. (2009) · Endocrinology · doi:10.1210/en.2008-1003 · Cited by 275

Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance

Freemark, M. (2002) · Endocrinology · doi:10.1210/en.143.4.1378 · Cited by 258

Human placental growth hormone causes severe insulin resistance in transgenic mice

Barbour, L. A., Shao, J., Qiao, L., Pulawa, L. K., Jensen, D. R., Bartke, A., Garrity, M., Draznin, B., & Friedman, J. E. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.121256 · Cited by 214

Targeted Expression of Placental Lactogen in the Beta Cells of Transgenic Mice Results in Beta Cell Proliferation, Islet Mass Augmentation, and Hypoglycemia

Vasavada, R. C., Garcia-Ocaña, A., Zawalich, W. S., Sorenson, R. L., Dann, P., Syed, M., Ogren, L., Talamantes, F., & Stewart, A. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15399 · Cited by 212

Human Placental Growth Hormone Increases Expression of the P85 Regulatory Unit of Phosphatidylinositol 3-Kinase and Triggers Severe Insulin Resistance in Skeletal Muscle

Barbour, L. A., Shao, J., Qiao, L., Leitner, W., Anderson, M., Friedman, J. E., & Draznin, B. (2004) · Endocrinology · doi:10.1210/en.2003-1297 · Cited by 208

Placental growth hormone levels in normal pregnancy and in pregnancies with intrauterine growth retardation

Mirlesse, V., Frankenne, F., Alsat, E., Poncelet, M., Hennen, G., & Evain-Brion, D. (1993) · Pediatric Research · doi:10.1203/00006450-199310000-00011 · Cited by 202

Uteroplacental vascular development and placental function: an update

Reynolds, L. P., Borowicz, P. P., Caton, J. S. S., Vonnahme, K. A., Luther, J. S., Buchanan, D. S., Hafez, S. A., Grazul‐Bilska, A. T., & Redmer, D. A. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082799lr · Cited by 191

Weights of Placentae From Small-for-Gestational Age Infants Revisited

Heinonen, S. T., Taipale, P., & Saarikoski, S. (2001) · Placenta · doi:10.1053/plac.2001.0630 · Cited by 185

Human Placental Growth Hormone—A Review

Lacroix, M. C., Guibourdenche, J., Frendo, J., MULLER, F. M., & Evain‐Brion, D. (2002) · Placenta · doi:10.1053/plac.2002.0811 · Cited by 177

Placental Growth Hormone (GH), GH-Binding Protein, and Insulin-Like Growth Factor Axis in Normal, Growth-Retarded, and Diabetic Pregnancies: Correlations with Fetal Growth

McIntyre, D. H., Serek, R., Crane, D. I., Veveris-Lowe, T. L., Parry, A., Johnson, S. L., Leung, K. C., Ho, K. K. Y., Bougoussa, M., Hennen, G. P., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6480 · Cited by 175

Growth Factors and Intrauterine Growth Retardation. II. Serum Growth Hormone, Insulin-Like Growth Factor (IGF) I, and IGF-Binding Protein 3 Levels in Children with Intrauterine Growth Retar Age1

Léger, J., Noël, M., Limal, J. M., & Czernichow, P. (1996) · Pediatric Research · doi:10.1203/00006450-199607000-00018 · Cited by 172

Adipokines and insulin resistance during pregnancy

Zavalza-Gómez, A. B., Anaya‐Prado, R., Rincón‐Sánchez, A. R., & Mora-Martínez, J. M. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.12.012 · Cited by 160

The transcriptional response of the islet to pregnancy in mice

Rieck, S., White, P., Schug, J., Fox, A. J., Smirnova, O., Gao, N., Gupta, R. K., Wang, Z. V., Scherer, P. E., Keller, M. P., et al. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0144 · Cited by 160

Regulation of maternal IGF-I by placental GH in normal and abnormal human pregnancies

Caufriez, A., Frankenne, F., Hennen, G. P., & Copinschi, G. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.4.e572 · Cited by 156

Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy

Schraenen, A., Lemaire, K., de Faudeur, G., Hendrickx, N., Granvik, M., Lommel, L. V., Mallet, J. J., Vodjdani, G., Gilon, P., Binart, N., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1913-7 · Cited by 150

Increased P85α Is a Potent Negative Regulator of Skeletal Muscle Insulin Signaling and Induces in Vivo Insulin Resistance Associated with Growth Hormone Excess

Barbour, L. A., Rahman, S. M., Gurevich, I., Leitner, J. W., Fischer, S. J., Roper, M. D., Knotts, T. A., Vo, Y., McCurdy, C. E., Yakar, S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506967200 · Cited by 143

Physiological role of human placental growth hormone

Alsat, E., Guibourdenche, J., Couturier, A., & Evain‐Brion, D. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00040-9 · Cited by 136

Growth hormone isoforms

Baumann, G. P. (2009) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2009.04.011 · Cited by 134

Pregnancy‐Induced Adaptation in the Neuroendocrine Control of Prolactin Secretion

Grattan, D. R., Steyn, F. J., Kokay, I. C., Anderson, G. M., & Bunn, S. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01661.x · Cited by 132

De novo synthesis of estrogen in pregnant uterus is critical for stromal decidualization and angiogenesis

Das, A., Mantena, S. R., Kannan, A., Evans, D. B., Bagchi, M. K., & Bagchi, I. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901647106 · Cited by 131

Regulation of Maternal Metabolism by Pituitary and Placental Hormones: Roles in Fetal Development and Metabolic Programming

Freemark, M. (2006) · Hormone Research in Paediatrics · doi:10.1159/000091505 · Cited by 118

Human placental growth hormone

Alsat, E., Guibourdenche, J., Luton, D., Frankenne, F., & Evain-Brion, D. (1997) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(97)70103-0 · Cited by 113

Induction of Central Leptin Resistance in Hyperphagic Pseudopregnant Rats by Chronic Prolactin Infusion

Augustine, R. A., & Grattan, D. R. (2007) · Endocrinology · doi:10.1210/en.2007-1018 · Cited by 111

Absence of human placental lactogen in an otherwise uneventful pregnancy

Nielsen, P. V., Pedersen, H., & Kampmann, E. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(79)90698-7 · Cited by 97

Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation

Fujinaka, Y., Takane, K., Yamashita, H., & Vasavada, R. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702607200 · Cited by 92

Hyperphagia and Central Mechanisms for Leptin Resistance during Pregnancy

Trujillo‐Güiza, M. L., Spuch, C., Carro, E., & Señarís, R. M. (2011) · Endocrinology · doi:10.1210/en.2010-0975 · Cited by 90

A Gene Deletion is Responsible for Absence of Human Chorionic Somatomammotropin

WURZEL, J. M., Parks, J. S., Herd, J. E., & NIELSEN, P. V. (1982) · DNA · doi:10.1089/dna.1.1982.1.251 · Cited by 84

Neuropeptide Y and Tuberoinfundibular Dopamine Activities Are Altered during Lactation: Role of Prolactin**This work was supported by NIH Grants HD-14643 and HD-18185 and Oregon Regional Primate Research Center Grant RR-00163.

Li, C., Chen, P., & Smith, M. S. (1999) · Endocrinology · doi:10.1210/endo.140.1.6437 · Cited by 81

Ontogenesis of prolactin receptor gene expression in the rat olfactory system: potential roles for lactogenic hormones in olfactory development

Freemark, M., Driscoll, P., Andrews, J. S., Kelly, P. A., & Royster, M. (1996) · Endocrinology · doi:10.1210/endo.137.3.8603606 · Cited by 67

Differential Expression Profile ofGrowth Hormone/Chorionic SomatomammotropinGenes in Placenta of Small- and Large-for-Gestational-Age Newborns

Männik, J., Vaas, P., Rull, K., Teesalu, P., Rebane, T., & Laan, M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0023 · Cited by 66

Aspects of placental growth hormone physiology

Fuglsang, J., & Ovesen, P. (2006) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2006.03.010 · Cited by 66

Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction

Koutsaki, M., Sifakis, S., Zaravinos, A., Koutroulakis, D., Koukoura, O., & Spandidos, D. A. (2011) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2010.12.002 · Cited by 65

Absence of human placental lactogen and placental growth hormone (HGH-V) during pregnancy: PCR analysis of the deletion

Rygaard, K., Revol, A., Escobedo, D. E., Beck, B. L., & Barrera-Saldaña, H. A. (1998) · Human Genetics · doi:10.1007/s004390050658 · Cited by 62

The Interplay of Prolactin and the Glucocorticoids in the Regulation of β-Cell Gene Expression, Fatty Acid Oxidation, and Glucose-Stimulated Insulin Secretion: Implications for Carbohydrate Metabolism in Pregnancy

Arumugam, R., Horowitz, E., Lu, D., Collier, J. J., Ronnebaum, S. M., Fleenor, D., & Freemark, M. (2008) · Endocrinology · doi:10.1210/en.2008-0051 · Cited by 61

Roles of the Lactogens and Somatogens in Perinatal and Postnatal Metabolism and Growth: Studies of a Novel Mouse Model Combining Lactogen Resistance and Growth Hormone Deficiency

Fleenor, D. E., Oden, J., Kelly, P. A., Mohan, S., Alliouachene, S., Pende, M., Wentz, S. C., Kerr, J., & Freemark, M. (2004) · Endocrinology · doi:10.1210/en.2004-0744 · Cited by 57

Placental Lactogen Levels in Diabetic Pregnancy

Ursell, W., Brudenell, M. J., & Chard, T. (1973) · BMJ · doi:10.1136/bmj.2.5858.80 · Cited by 55

Absence of human chorionic somatomammotropin during pregnancy associated with two types of gene deletion

Simon, P., Decoster, C. G., Brocas, H., Schwers, J., & Vassart, G. (1986) · Human Genetics · doi:10.1007/bf00282540 · Cited by 54

Placental growth hormone is increased in the maternal and fetal serum of patients with preeclampsia

Mittal, P., Espinoza, J., Hassan, S. S., Kusanovic, J. P., Edwin, S. S., Nien, J. K., Gotsch, F., Than, N. G., Erez, O., Mazaki‐Tovi, S., et al. (2007) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050701463571 · Cited by 54

Human Placental Lactogen Infusions into the Medial Preoptic Area Stimulate Maternal Behavior in Steroid-Primed, Nulliparous Female Rats

Bridges, R. S., & Freemark, M. (1995) · Hormones and Behavior · doi:10.1006/hbeh.1995.1016 · Cited by 50

Changes in Agouti‐Related Peptide During the Ring Dove Breeding Cycle in Relation to Prolactin and Parental Hyperphagia

Strader, A. D., & Buntin, J. D. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01092.x · Cited by 44

Placental growth hormone and IGF‐I in a pregnant woman with Pit‐1 deficiency

Verhaeghe, J., Bougoussa, M., Herck, E. V., de Zegher, F., HENNEN, G., & Igout, A. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01044.x · Cited by 44

Constitutive Expression of Placental Lactogen in Pancreatic β Cells: Effects on Cell Morphology, Growth, and Gene Expression

Fleenor, D., Petryk, A., Driscoll, P., & Freemark, M. (2000) · Pediatric Research · doi:10.1203/00006450-200001000-00023 · Cited by 44

Endocrine-metabolic response to acute starvation in human gestation

Tyson, J. E., Austin, K. L., Farinholt, J. W., & Fiedler, J. H. (1976) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(76)90811-5 · Cited by 43

Somatogenic and lactogenic activity of the recombinant 22 kDa isoform of human placental growth hormone.

Igout, A., Frankenne, F., L’Hermite‐Balériaux, M., Martin, A., & HENNEN, G. (1995) · PubMed · Cited by 39

Ghrelin in Pregnancy and Lactation

Fuglsang, J. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(06)77011-x · Cited by 34

Regulation of Islet β-Cell Pyruvate Metabolism: Interactions of Prolactin, Glucose, and Dexamethasone

Arumugam, R., Horowitz, E., Noland, R. C., Lu, D., Fleenor, D. E., & Freemark, M. (2010) · Endocrinology · doi:10.1210/en.2010-0049 · Cited by 32

Differential and Complementary Effects of Glucose and Prolactin on Islet DNA Synthesis and Gene Expression

Arumugam, R., Fleenor, D. E., Lu, D., & Freemark, M. (2011) · Endocrinology · doi:10.1210/en.2010-1258 · Cited by 29

ISOLATED DEFECT IN HUMAN PLACENTAL LACTOGEN SYNTHESIS IN A NORMAL PREGNANCY

Borody, I. B., & Carlton, M. A. (1981) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1981.tb01011.x · Cited by 28

Immunologically undetectable human placental lactogen in a normal pregnancy.

Sideri, M. G., de Virgiliis, G., GUIDOBONO, F., Borgese, N., Sereni, L. P., Nicolini, U., & Remotti, G. (1983) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1983.tb09309.x · Cited by 22

20-kDa placental hGH-V has diminished diabetogenic and lactogenic activities compared with 22-kDa hGH-N while retaining antilipogenic activity

Vickers, M. H., Gilmour, S., Gertler, A., Breier, B. H., Tunny, K. A., Waters, M. J., & Gluckman, P. D. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00221.2009 · Cited by 19

Placental protein profile and glucose studies in a normal pregnancy with extremely low levels of human placental lactogen. Case report

ALEXANDER, I., Anthony, F. W., & Letchworth, A. T. (1982) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1982.tb03623.x · Cited by 17

Failure of placenta to produce hPL in an otherwise uneventful pregnancy: a case report.

Barbieri, F., Botticelli, A., Consarino, R., Genazzani, A. R., & Volpe, A. (1986) · PubMed · Cited by 11

Human Placental Lactogen Hormone in Serum from Pregnant Women with Rhesus (Anti‐D) Isoimmunization

Bock, J. E., Gæde, P., & Trolle, D. (1976) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016347609156440 · Cited by 8

[Low or absent serum placental lactogen hormone in 2 normal pregnancies].

Wøhlk, P., Nexø, E., Jørgensen, E. H., Chemnitz, J., Pv, N., & Parks, J. S. (1984) · PubMed · Cited by 5

[A pregnancy without detectable human placental lactogen (hPL)].

Trapp, M., De Wilde, R., Holzgreve, W., Hj, S., & Hg, B. (1987) · PubMed · Cited by 5

Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy

Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Kling Bäckhed, H., Gonzalez, A., Werner, J. J., Angenent, L. T., Knight, R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.008 · Cited by 2,165

Physiological changes in pregnancy

Soma-Pillay, P., Nelson-Piercy, C., Tolppanen, H., & Mebazaa, A. (2016) · Cardiovascular Journal of Africa · doi:10.5830/cvja-2016-021 · Cited by 1,483

The Placenta: A Multifaceted, Transient Organ

Burton, G. J., & Fowden, A. L. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0066 · Cited by 833

Placental Origins of Chronic Disease

Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717

Microbial Changes during Pregnancy, Birth, and Infancy

Nuriel‐Ohayon, M., Neuman, H., & Koren, O. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01031 · Cited by 647

The Roles of Growth Hormone, Prolactin and Placental Lactogen In Maternal Metabolism and Fetal Development

Freemark, M., & Handwerger, S. (2001) · Endocrine updates · doi:10.1007/978-1-4615-1435-0_2

Placental hormones and the control of fetal growth

Freemark, M. (2015) · International Journal of Pediatric Endocrinology · doi:10.1186/1687-9856-2015-s1-o13 · Cited by 3

Some Aspects of Endocrinology of the Placenta

Longo, L. D. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7483-2_9 · Cited by 1

Placental control of metabolic adaptations in the mother for an optimal pregnancy outcome. What goes wrong in gestational diabetes?

Hill, D. J. (2018) · Placenta · doi:10.1016/j.placenta.2018.01.002 · Cited by 46

The Roles of Placental Growth Hormone and Placental Lactogen in the Regulation of Human Fetal Growth and Development

Handwerger, S., & Freemark, M. (2000) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2000.13.4.343 · Cited by 362