The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Evolving utility of sex hormone-binding globulin measurements in clinical medicine
Abstract
PURPOSE OF REVIEW: Sex hormone-binding globulin (SHBG) regulates the plasma levels and biological actions of the sex steroids: testosterone and estradiol. Advances in our understanding of how plasma SHBG levels are determined, and how SHBG functions, have provided insight into how SHBG should be used to assess the actions of its sex-steroid ligands, and as a biomarker of metabolic and endocrine abnormalities. RECENT FINDINGS: Plasma SHBG levels fluctuate throughout life in response to the changes in metabolic and physiologic states, and are altered by natural hormones and synthetic steroids. Interindividual differences in plasma SHBG levels and activity are also influenced by polymorphisms within the structural and regulatory regions of the SHBG gene. SUMMARY: Measurements of SHBG are widely used to predict plasma free testosterone levels in patients suffering from excess androgen exposures, but have broader utility in assessing the risk for endocrine diseases and clinical sequelae of the metabolic syndrome, namely, type 2 diabetes and cardiovascular disease. It is anticipated that new genetic and functional data regarding SHBG will reveal whether SHBG is simply a biomarker of these diseases or participants in their cause.
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“SHBG is a marker of de novo hepatic lipogenesis in both men and women [81], [82].”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [81]
In the citing paper
“The apparent contradiction that low testosterone levels are associated with insulin resistance and the metabolic syndrome in men when the association is with high testosterone levels in women is the result of the decrease in SHBG and its consequent effect on the assessment of testosterone in each sex [81].”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [81]
In the citing paper
“Similar to findings with the AR gene, SHBG polymorphisms also directly impact the expression and variability of SHBG itself as well as systemic fT and E2.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [100]
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Self-citationPeroxisome-Proliferator Receptor γ Represses Hepatic Sex Hormone-Binding Globulin Expression
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Metadata
- Authors
- Hammond, G. L., Wu, T.-S., & Simard, M.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Hammond, Geoffrey L.
- Venue
- Current Opinion in Endocrinology, Diabetes & Obesity
- Published
- 2012-06
- Volume
- 19
- Issue
- 3
- Pages
- 183-189
- ISSN
- 1752-296X (ISSN-L)
- OpenAlex
- W2145626737
- Cited by
- 104
- References
- 53
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 13 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 14 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Endocrinology Diabetes and Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canada Research Chairs
- Canadian Institutes of Health Research (MOP 15261)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- sex hormone-binding globulin, free testosterone, sex steroids, metabolic syndrome, type 2 diabetes, cardiovascular disease, endocrine disorders, biomarkers, hyperandrogenism
- MeSH terms
- Estradiol, Female, Humans, Male, Polymorphism, Genetic, Predictive Value of Tests, Risk, Sex Hormone-Binding Globulin, Testosterone, Biomarkers, Sex Distribution, Metabolic Syndrome
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