Cited by 104Hormonal and reproductive studiesEstrogen and related hormone effectsSexual Differentiation and Disorders

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Evolving utility of sex hormone-binding globulin measurements in clinical medicine

Hammond, Geoffrey L., Wu, Tsung-Sheng, Simard, Marc·2012·Current Opinion in Endocrinology, Diabetes & Obesity

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Abstract

PURPOSE OF REVIEW: Sex hormone-binding globulin (SHBG) regulates the plasma levels and biological actions of the sex steroids: testosterone and estradiol. Advances in our understanding of how plasma SHBG levels are determined, and how SHBG functions, have provided insight into how SHBG should be used to assess the actions of its sex-steroid ligands, and as a biomarker of metabolic and endocrine abnormalities. RECENT FINDINGS: Plasma SHBG levels fluctuate throughout life in response to the changes in metabolic and physiologic states, and are altered by natural hormones and synthetic steroids. Interindividual differences in plasma SHBG levels and activity are also influenced by polymorphisms within the structural and regulatory regions of the SHBG gene. SUMMARY: Measurements of SHBG are widely used to predict plasma free testosterone levels in patients suffering from excess androgen exposures, but have broader utility in assessing the risk for endocrine diseases and clinical sequelae of the metabolic syndrome, namely, type 2 diabetes and cardiovascular disease. It is anticipated that new genetic and functional data regarding SHBG will reveal whether SHBG is simply a biomarker of these diseases or participants in their cause.

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Authors: Hammond, G. L., Wu, T.-S., & Simard, M.
Affiliations: University of British Columbia (CA)
Corresponding author: Hammond, Geoffrey L.
ORCID: Hammond, Geoffrey L.
Simard, Marc
Venue: Current Opinion in Endocrinology, Diabetes & Obesity
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-06
Volume: 19
Issue: 3
Pages: 183-189
ISSN: 1752-296X (ISSN-L)
DOI: 10.1097/med.0b013e328353732f
OpenAlex: W2145626737
Cited by: 104
References: 53
Citations by year: 2026: 2 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 13 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 14 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 1
FWCI: 0.84
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Endocrinology Diabetes and Obesity (publishedVersion)
PubMed (publishedVersion)
Funders: Canada Research Chairs
Canadian Institutes of Health Research (MOP 15261)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: sex hormone-binding globulin, free testosterone, sex steroids, metabolic syndrome, type 2 diabetes, cardiovascular disease, endocrine disorders, biomarkers, hyperandrogenism
MeSH terms: Estradiol, Female, Humans, Male, Polymorphism, Genetic, Predictive Value of Tests, Risk, Sex Hormone-Binding Globulin, Testosterone, Biomarkers, Sex Distribution, Metabolic Syndrome

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Evolving utility of sex hormone-binding globulin measurements in clinical medicine

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