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Cited by 37Liver Disease Diagnosis and TreatmentAlcohol Consumption and Health EffectsDiabetes, Cardiovascular Risks, and Lipoproteins

Weight change and resolution of fatty liver in normal weight individuals with nonalcoholic fatty liver disease

Sinn, Dong Hyun, Kang, Danbee, Cho, Soo Jin, Paik, Seung Woon, Guallar, Eliseo, Cho, Juhee, Gwak, Geum-Youn·2021·European Journal of Gastroenterology & Hepatology
DOI 10.1097/meg.0000000000002158
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Abstract

OBJECTIVES: Obesity is a well-known risk factor for nonalcoholic fatty liver disease (NAFLD), and weight reduction is primarily recommended for managing the disease. However, some NAFLD patients have a normal weight (lean NAFLD), and whether weight reduction is also recommendable for lean NAFLD patients remains unclear. METHODS: We conducted a longitudinal study of 16 738 adults (average age, 50.5 years; lean NAFLD, 2383 participants) with NAFLD at baseline who underwent repeated health check-up examinations, including bodyweight measurements and abdominal ultrasonography from January 2003 through December 2013. RESULTS: During 68 389 person-years of follow-up (median follow-up of 3.00 years), 5819 patients had a fatty liver resolution. Compared with participants who had no weight reduction or increased weight, the fully adjusted hazard ratios for fatty liver resolution in participants with 0-4.9, 5-9.9 and 10% or more weight reduction were 1.67 [95% confidence interval (CI), 1.57-1.77], 3.36 (95% CI, 3.09-3.65) and 5.50 (95% CI, 4.83-6.27), respectively. The association between weight reduction and the fatty liver resolution was stronger in overweight/obese NAFLD participants but was also evident in lean NAFLD participants in a dose-dependent manner. In spline regression models, the association between weight change and the fatty liver resolution was linear among participants with normal weight. CONCLUSION: There was a dose-dependent association between weight reduction and fatty liver resolution in both lean and overweight/obese NAFLD patients. This finding suggests weight reduction as a primary recommendation for lean NAFLD patients as in overweight/obese NAFLD patients.

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Crossref · 10.1097/meg.0000000000002158

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  • In a large cohort study that included 2,383 normal-weight adults with MASLD, weight reduction over a median follow-up of 3 years was associated with MASLD resolution (measured by abdominal ultrasound) in a dose-dependent manner.

    “Similarly, in a large cohort study that included 2,383 normal-weight adults with MASLD, weight reduction over a median follow-up of 3 years was associated with MASLD resolution (measured by abdominal ultrasound) in a dose-dependent manner. 334”

    From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [334]

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Authors
Sinn, D. H., Kang, D., Cho, S. J., Paik, S. W., Guallar, E., Cho, J., & Gwak, G.-Y.
Affiliations
  • Samsung Medical Center (KR)
  • Department of Clinical Research Design and Evaluation, SAIHST
  • Johns Hopkins University (US)
Corresponding author
  • Sinn, Dong Hyun
  • Kang, Danbee
Venue
European Journal of Gastroenterology & Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2021-04-16
Volume
33
Issue
1S
Pages
e529-e534
ISSN
0954-691X (ISSN-L)
DOI
10.1097/meg.0000000000002158
OpenAlex
W3155327468
Cited by
37
References
40
Citations by year
2026: 5 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 5
FWCI
4.68
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Gastroenterology & Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
non-alcoholic fatty liver disease, lean NAFLD, weight loss, weight change, obesity, dose-response relationship, abdominal ultrasound, normal-weight individuals
MeSH terms
Adult, Humans, Longitudinal Studies, Middle Aged, Obesity, Weight Loss, Body Mass Index, Overweight, Non-alcoholic Fatty Liver Disease

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