Effect of fermented milk-based probiotic preparations on Helicobacter pylori eradication: a systematic review and meta-analysis of randomized-controlled trials
Abstract
OBJECTIVE: To evaluate the effect of fermented milk-based probiotic preparations on Helicobacter pylori eradication. DESIGN: Systematic review of randomized controlled trials. DATA SOURCES: Electronic databases and hand search of reviews, bibliographies of books and abstracts and proceedings of international conferences. REVIEW METHODS: Included trials had to be randomized or quasi-randomized and controlled, using fermented milk-based probiotics in the intervention group, treating Helicobacter-infected patients and evaluating improvement or eradication of H. pylori as an outcome. RESULTS: The search identified 10 eligible randomized controlled trials. Data were available for 963 patients, of whom 498 were in the treatment group and 465 in the control group. The pooled odds ratio (studies n=9) for eradication by intention-to-treat analysis in the treatment versus control group was 1.91 (1.38-2.67; P<0.0001) using the fixed effects model; test for heterogeneity (Cochran's Q=5.44; P=0.488). The pooled risk difference was 0.10 (95% CI 0.05-0.15; P<0.0001) by the fixed effects model (Cochran's Q=13.41; P=0.144). The pooled odds ratio for the number of patients with any adverse effect was 0.51 (95% CI 0.10-2.57; P=0.41; random effects model; heterogeneity by Cochran's Q=68.5; P<0.0001). CONCLUSION: Fermented milk-based probiotic preparations improve H. pylori eradication rates by approximately 5-15%, whereas the effect on adverse effects is heterogeneous.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A meta-analysis of Helicobacter pylori eradication by probiotics delivered in fermented milk products showed that efficacy was better than that of capsule/sachet-based bacteria-only preparations.
“A meta-analysis of Helicobacter pylori eradication by probiotics delivered in fermented 2 milk products showed that efficacy was better than that of capsule/sachet-based bacteria-only 3 preparations 46 .”
Cites
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689 · see citing works
Gotteland, M., Poliak, L., Cruchet, S., & Brunser, O. (2005) · Acta Paediatrica · doi:10.1111/j.1651-2227.2005.tb01848.x · Cited by 111 · see citing works
Kim, B. G., Lee, D. H., Ye, B. D., et al. (2007) · Helicobacter · doi:10.1111/j.1523-5378.2007.00468.x · Cited by 104 · see citing works
Sullivan, Å., Bennet, R., Viitanen, M. H., Palmgren, A., & Nord, C. E. (2002) · Microbial Ecology in Health and Disease · doi:10.1080/089106002760003305 · Cited by 22 · see citing works
Sullivan, Å., Bennet, R., Viitanen, M. H., Palmgren, A., & Nord, C. E. (2002) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v14i1.8205 · Cited by 17 · see citing works
Helicobacter pylori Infection in Pediatrics
Mourad‐Baars, P. E. C., & Chong, S. K. F. (2006) · Helicobacter · doi:10.1111/j.1478-405x.2006.00427.x · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Flach, J., van der Waal, M. B., van den Nieuwboer, M., Claassen, E., & Larsen, O. F. A. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1334624 · Cited by 131 · see citing works
de Vrese, M., Kristen, H., Rautenberg, P., Laue, C., & Schrezenmeir, J. (2011) · Journal of Dairy Research · doi:10.1017/s002202991100063x · Cited by 84 · see citing works
Bekar, O., Yilmaz, Y., & Gulten, M. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.0099 · Cited by 84 · see citing works
Dimidi, E., Zdanaviciene, A., Christodoulides, S., Taheri, S., Louis, P., Duncan, P. I., Emami, N., Crabbé, R., De Castro, C. A., McLean, P., et al. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15073 · Cited by 80 · see citing works
Meng, H., Ba, Z., Lee, Y., Peng, J., Lin, J., Fleming, J. A., Furumoto, E. J., Roberts, R. F., Kris-Etherton, P. M., & Rogers, C. J. (2017) · European Journal of Nutrition · doi:10.1007/s00394-015-1109-5 · Cited by 52 · see citing works
- Authors
- Sachdeva, A., & Nagpal, J.
- Affiliations
- Sitaram Bhartia Institute of Science and Research (IN)
- Corresponding author
- Nagpal, Jitender
- ORCID
- Nagpal, Jitender
- Venue
- European Journal of Gastroenterology & Hepatology
- Published
- 2009-01
- Volume
- 21
- Issue
- 1
- Pages
- 45-53
- ISSN
- 0954-691X (ISSN-L)
- OpenAlex
- W2069978507
- Cited by
- 112
- References
- 7
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 12 · 2014: 9 · 2013: 9 · 2012: 9
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Helicobacter pylori, probiotics, fermented milk, probiotic therapy, Helicobacter pylori eradication, adverse effects, Helicobacter infection
- MeSH terms
- Adult, Child, Humans, Randomized Controlled Trials as Topic, Helicobacter pylori, Helicobacter Infections, Treatment Outcome, Probiotics, Cultured Milk Products
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
