Validation of the Spanish Work Productivity and Activity impairment questionnaire: Crohnʼs disease version
Abstract
BACKGROUND: The Work Productivity and Activity Impairment questionnaire has only been partially validated in Crohn's disease. OBJECTIVE: To test the Work Productivity and Activity Impairment questionnaire for use in Crohn's disease patients. METHODS: A validated Spanish translation of the test was assessed. 'Discriminant validity' was evaluated by comparing Work Productivity and Activity Impairment scores in Crohn's disease patients with active versus inactive disease, and in patients versus healthy controls. 'Convergent validity' was tested comparing Work Productivity and Activity Impairment questionnaire with quality of life, Crohn's disease activity index and a debriefing questionnaire. 'Reproducibility' of repeated tests was evaluated by comparing two Work Productivity and Activity Impairment measures obtained 2 weeks apart in stable patients. 'Responsiveness' was determined by comparing Work Productivity and Activity Impairment values in the same patients during a flare-up of Crohn's disease and during remission. The Wilcoxon test for paired data and the Mann-Whitney U test for unpaired data were used for comparisons. RESULTS: One hundred and six patients were included in the various steps of the analysis. All Work Productivity and Activity Impairment parameters showed adequate discriminant and convergent validity and responsiveness. The test's reproducibility was also adequate, except for the evaluation of presenteeism (the impairment of productivity while working). CONCLUSION: The Spanish Work Productivity and Activity Impairment questionnaire is a valid and reliable measurement of work impairment in Crohn's disease. Unexpectedly, the test did not present satisfactory reproducibility for the evaluation of presenteeism. The reliability of this last finding should be evaluated in further studies.
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The WPAI and SF-12 had prior Spanish translations and validation.
“WPAI and SF-12® have been translated to Spanish and validated previously (38, 39).”
From Quantification of the impact of endometriosis symptoms on health-related quality of life and work productivity (2011) · cites this paper as [39]
Cites
The Validity and Reproducibility of a Work Productivity and Activity Impairment Instrument
Reilly, M. C., Zbrozek, A. S., & Dukes, E. M. (1993) · PharmacoEconomics · doi:10.2165/00019053-199304050-00006 · Cited by 3,071 · see citing works
A SIMPLE INDEX OF CROHN'S-DISEASE ACTIVITY
Harvey, R. F., & Bradshaw, J. M. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92767-1 · Cited by 2,974 · see citing works
Xu, D., He, X., Chang, Y., Sun, S., Xu, C., & Lin, J. (2012) · Hepatogastroenterology · doi:10.5754/hge12458 · Cited by 1,977 · see citing works
Deyo, R. A., Diehr, P. H., & Patrick, D. L. (1991) · Controlled Clinical Trials · doi:10.1016/s0197-2456(05)80019-4 · Cited by 1,369 · see citing works
(1999) · PubMed · Cited by 548 · see citing works
Casellas, F., Arenas, J. I., Baudet, J. S., Fábregas, S., García, N. C., Gelabert, J., Medina, C., Ochotorena, I., Papo, M., Rodrigo, L., et al. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000159661.55028.56 · Cited by 269 · see citing works
Self-citation祐子, 森., Solem, C. A., Sandborn, W. J., Booya, F., Loftus, E. V., Harmsen, W. S., Zinsmeister, A. R., Bodily, K. D., & Fletcher, J. G. (2006) · Gut · doi:10.1136/gut.2005.084301 · Cited by 238 · see citing works
Bernklev, T., Jahnsen, J., Lygren, I., Henriksen, M., Vatn, M., & Moum, B. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000179467.01748.99 · Cited by 236 · see citing works
Reilly, M. C., Bracco, A., Ricci, J. ‐., Santoro, J., & Stevens, T. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02091.x · Cited by 196 · see citing works
Reilly, M. C., Gerlier, L., Brabant, Y., & Brown, M. (2008) · Clinical Therapeutics · doi:10.1016/j.clinthera.2008.02.016 · Cited by 196 · see citing works
The burden of illness of gastro‐oesophageal reflux disease: impact on work productivity
Dean, B. B., Crawley, J. A., Schmitt, C. M., Wong, J. B., & Ofman, J. J. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01588.x · Cited by 162 · see citing works
Kobelt, G., Borgström, F., & Mattiasson, A. (2003) · British Journal of Urology · doi:10.1046/j.1464-410x.2003.04062.x · Cited by 151 · see citing works
Wahlqvist, P., Carlsson, J., Stålhammar, N., & Wiklund, I. E. (2002) · Value in Health · doi:10.1046/j.1524-4733.2002.52101.x · Cited by 146 · see citing works
MEASURING CROHN'S DISEASE ACTIVITY
Harvey, R., & Bradshaw, M. J. (1980) · The Lancet · doi:10.1016/s0140-6736(80)91577-9 · Cited by 122 · see citing works
Unemployment and Disability in Patients With Moderately to Severely Active Crohn's Disease
Feagan, B. G., BALA, M. M., Yan, S., Olson, A. D., & Hanauer, S. B. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000159220.70290.41 · Cited by 122 · see citing works
Turnbull, G. K., & Vallis, M. (1995) · PubMed · Cited by 121 · see citing works
Bernklev, T., Jahnsen, J., Schulz, T. B., Sauar, J., Lygren, I., Henriksen, M., Stray, N., Kjellevold, Y., Aadland, E., Vatn, M., et al. (2005) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200510000-00006 · Cited by 93 · see citing works
Shortened Questionnaire on Quality of Life for Inflammatory Bowel Disease
Alcalá, M. J., Casellas, F., Fontanet, G., Prieto, L. M., & Malagelada, J. R. (2004) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200407000-00009 · Cited by 78 · see citing works
Self-citationThe Education and Employment Status of Patients with Inflammatory Bowel Diseases
Marri, S. R., & Buchman, A. L. (2005) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200502000-00011 · Cited by 74 · see citing works
Reilly, M. C., Lavin, P. T., Kahler, K. H., & Pariser, D. M. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.128 · Cited by 74 · see citing works
Psychosocial Aspects of Crohn's Disease
Ringel, Y., & Drossman, D. A. (2001) · Surgical Clinics of North America · doi:10.1016/s0039-6109(05)70283-8 · Cited by 61 · see citing works
Ståhl, E., Jansson, S., Jonsson, A.-C., Svensson, K., Lundbäck, B., & Andersson, F. (2003) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-1-18 · Cited by 54 · see citing works
Feagan, B. G., Reilly, M. C., Gerlier, L. C., Brabant, Y., Brown, M. C. J., & Schreiber, S. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04303.x · Cited by 48 · see citing works
Calvet, X., Gallardo, O., Coronas, R., Casellas, F., Montserrat, A., Torrejón, A., Vergara, M., Campo, R., & Brullet, E. (2006) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200608000-00004 · Cited by 45 · see citing works
Self-citationVergara, M., Montserrat, A., Casellas, F., Villòria, A., Suarez, D. L., Maudsley, M., Gallardo, O., Ricart, E., & Calvet, X. (2011) · Value in Health · doi:10.1016/j.jval.2011.02.1179 · Cited by 40 · see citing works
Self-citationAssessment of disease activity in ulcerative colitis and Crohn's disease
Hodgson, H. J. F., & Bhatti, M. I. (1995) · Inflammatory Bowel Diseases · doi:10.1002/ibd.3780010206 · Cited by 36 · see citing works
The effects of clonazepam on quality of life and work productivity in panic disorder.
Jacobs, R. J., Davidson, J. R., Gupta, S., & Meyerhoff, A. S. (1997) · PubMed · Cited by 33 · see citing works
Gawlicki, M., Reilly, M. C., Popielnicki, A., & Reilly, K. (2006) · Value in Health · doi:10.1111/j.1524-4733.2006.00101.x · Cited by 30 · see citing works
Calvet, X., Bustamante, E., Montserrat, A., Figuls, M. R. I., Campo, R., Gené, E., & Brullet, E. (2000) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200012080-00016 · Cited by 13 · see citing works
Self-citationManejo de los efectos adversos del tratamiento
Andrade, R. J. (2006) · Gastroenterología y Hepatología · doi:10.1157/13097657 · Cited by 5 · see citing works
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“WPAI and SF-12® have been translated to Spanish and validated previously (38, 39).”
MethodPatient-reported outcomes as primary end points in clinical trials of inflammatory bowel disease
Williet, N., Sandborn, W. J., & Peyrin–Biroulet, L. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.02.016 · Cited by 260 · see citing works
Sick leave and disability pension in inflammatory bowel disease: A systematic review
Büsch, K., da Silva, S. A., Holton, M., Rabacow, F. M., Khalili, H., & Ludvigsson, J. F. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.06.006 · Cited by 61 · see citing works
Vergara, M., Montserrat, A., Casellas, F., Villòria, A., Suarez, D. L., Maudsley, M., Gallardo, O., Ricart, E., & Calvet, X. (2011) · Value in Health · doi:10.1016/j.jval.2011.02.1179 · Cited by 40 · see citing works
Self-citationGisbert, J. P., Donday, M. G., Riestra, S., Lucendo, A. J., Benítez, J. M., Navarro‐Llavat, M., Barrio, J., Morales-Alvarado, V. J., Rivero, M., Busquets, D., et al. (2024) · Gut · doi:10.1136/gutjnl-2024-333385 · Cited by 26 · see citing works
Mateen, B. A., Doogan, C., Hayward, K., Hourihan, S. J., Hurford, J., & Playford, E. D. (2016) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2016.06.013 · Cited by 24 · see citing works
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Vergara, M., Montserrat, A., Casellas, F., Gallardo, O., Suarez, D. L., Motos, J., Villòria, A., Miquel, M., Martínez‐Bauer, E., & Calvet, X. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21604 · Cited by 23 · see citing works
Self-citationGater, A., Kitchen, H., Heron, L., Pollard, C., Håkan‐Bloch, J., Højbjerre, L., Hansen, B. B., & Strandberg-Larsen, M. (2015) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1586/14737167.2015.1045883 · Cited by 10 · see citing works
Development and Validation of the Short Crohnʼs Disease Work Disability Questionnaire
Vergara, M., Sicilia, B., Prieto, L., Casellas, F., Ramos, A., Gomollón, F., & Calvet, X. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000678 · Cited by 10 · see citing works
Self-citationSaro, C., CEBALLOS, D. S., Muñoz, F., de la Coba, C., Aguilar, M. D., Lázaro, P., García-Sánchez, V., Hernández, M. V. C., Barrio, J., de Francisco, R., et al. (2016) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2016.4600/2016 · Cited by 9 · see citing works
Chaparro, M., Donday, M. G., Acosta, M. B., Domènech, E., Esteve, M., García-Sánchez, V., Nos, P., Panés, J., Martínez, C., Gisbert, J. P., et al. (2019) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284819874202 · Cited by 7 · see citing works
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Casellas, F. (2010) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082010001100001 · Cited by 5 · see citing works
Self-citationBerre, C. L., Bourreille, A., Flamant, M., Bouguen, G., Siproudhis, L., Dewitte, M., Dib, N., Cesbron-Métivier, É., Goronflot, T., Hanf, M., et al. (2020) · BMC Gastroenterology · doi:10.1186/s12876-020-01246-7 · Cited by 5 · see citing works
Friedli, T., Villiger, P., & Gantschnig, B. (2018) · International Journal of Health Professions · doi:10.2478/ijhp-2018-0008 · Cited by 6 · see citing works
Friedli, T., Villiger, P. M., & Gantschnig, B. E. (2018) · Zürcher Hochschule für Angewandte Wissenschaften digital collection (Zurich University of Applied Sciences) · doi:10.21256/zhaw-4666 · Cited by 2 · see citing works
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Ramos, A., Vergara, M., Melcarne, L., Sicilia, B., Gomollón, F., & Calvet, X. (2018) · Medicine · doi:10.1097/md.0000000000012486 · Cited by 1 · see citing works
Self-citationMargarit, E., López‐Ferrer, A., Vilarrasa, E., & Puig, L. (2017) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2017.02.035
Margarit, E., López‐Ferrer, A., Vilarrasa, E., & Puig, L. (2018) · Actas Dermo-Sifiliográficas · doi:10.1016/j.adengl.2017.02.029
Berre, C. L., Bourreille, A., Flamant, M., Bouguen, G., Siproudhis, L., Dewitte, M., Dib, N., Cesbron-Metivier, E., Goronflot, T., Hanf, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12143946
Berre, C. L., Bourreille, A., Flamant, M., Bouguen, G., Siproudhis, L., Dewitte, M., Dib, N., Cesbron-Metivier, E., Goronflot, T., Hanf, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12143928
Berre, C. L., Bourreille, A., Flamant, M., Bouguen, G., Siproudhis, L., Dewitte, M., Dib, N., Cesbron-Metivier, E., Goronflot, T., Hanf, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12143943
Berre, C. L., Bourreille, A., Flamant, M., Bouguen, G., Siproudhis, L., Dewitte, M., Dib, N., Cesbron-Metivier, E., Goronflot, T., Hanf, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12143937
Development and validation of the inflammatory bowel disease objective disability index (IBDODI)
Melcarne, L., Brunet, E., Villòria, A., Vergara, M., Puy, A., Llovet, L. P., Frisancho, L. E., García-Sagué, B., Valero, O., Calvet, X., et al. (2026) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2026.11797/2025
Self-citation
- Authors
- Vergara, M., Montserrat, A., Casellas, F., Maudsley, M., Gallardo, O., Ricart, E., & Calvet, X.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Universitat de Barcelona (ES)
- Instituto de Salud Carlos III (ES)
- Corresponding author
- Vergara, Mercedes
- Venue
- European Journal of Gastroenterology & Hepatology
- Published
- 2009-07
- Volume
- 21
- Issue
- 7
- Pages
- 809-815
- ISSN
- 0954-691X (ISSN-L)
- OpenAlex
- W1987785007
- Cited by
- 24
- References
- 30
- Citations by year
- 2026: 1 · 2024: 1 · 2020: 6 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 2
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
- Keywords
- Work Productivity and Activity Impairment, Crohn's disease, work impairment, presenteeism, Spanish translation, questionnaire validation, discriminant validity, convergent validity, reproducibility, responsiveness, disease activity, flare-ups, quality of life
- MeSH terms
- Activities of Daily Living, Adult, Crohn Disease, Efficiency, Female, Humans, Language, Male, Quality of Life, Surveys and Questionnaires, Severity of Illness Index, Spain, Work, Reproducibility of Results, Sick Leave
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