Cited by 53Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlBalance, Gait, and Falls Prevention

A Review of the Etiology, Asssociated Comorbidities, and Treatment of Orthostatic Hypotension

Perlmuter, Lawrence C., Sarda, Garima, Casavant, Vanessa, Mosnaim, Aron D.·2013·American Journal of Therapeutics

Abstract

The magnitude of increase in systolic blood pressure in response to the shift from supine to upright posture is considered to reflect the adequacy of orthostatic regulation. Orthostatic integrity is largely maintained by the interaction between the skeletal muscle pump, neurovascular compensation, neurohumoral effects, and cerebral blood flow regulation. Various physiological states and disease conditions may disrupt these mechanisms as seen in vasovagal syncope, dysautonomic orthostatic intolerance, and postural orthostatic tachycardia syndrome. Orthostatic hypotension (OH) and decreased cerebral blood flow are strongly related. Even subclinical OH has been associated to different degrees with impaired cognitive function, decreased effort, reduced motivation, increased hopelessness, and signs of attention-deficit hyperactivity disorder and dementia, diabetes mellitus, and Parkinson disease. Furthermore, subclinical levels of inadequate blood pressure regulation in response to orthostasis have been linked to increased depression and anxiety and intergenerational behavioral sequelae between mother and child. Identifying causes of subclinical and clinical OH is critical in improving quality of life for both children and older adults. A better understanding of the underlying causes responsible for the etiology of OH could lead to a rational design of novel effective therapeutic regimens for the treatment of this condition and associated comorbidities.

Integrity signals

Registry

Crossref · 10.1097/mjt.0b013e31828bfb7f

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A more direct association is proposed between orthostatic hypotension and specific behavioral and emotional differences.

    “Moreover, a more direct association is proposed between orthostatic hypotension and specific behavioral and emotional differences (34).”

Cites

Flagged first, then by citations

2 of the 77 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Perlmuter, L. C., Sarda, G., Casavant, V., & Mosnaim, A. D.
Affiliations
Rosalind Franklin University of Medicine and Science (US)
Corresponding author
Mosnaim, Aron D.
Venue
American Journal of Therapeutics
Published
2013-05
Volume
20
Issue
3
Pages
279-291
ISSN
1075-2765 (ISSN-L)
OpenAlex
W2013172832
Cited by
53
References
77
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2022: 7 · 2021: 2 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 3
FWCI
0.94
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
Keywords
orthostatic hypotension, postural orthostatic tachycardia syndrome, vasovagal syncope, cerebral blood flow, orthostatic regulation, skeletal muscle pump, neurohumoral regulation, comorbidities, anxiety and depression, attention deficit hyperactivity disorder, dementia, Parkinson's disease, diabetes mellitus
MeSH terms
Anxiety, Cognition Disorders, Depression, Humans, Hypotension, Orthostatic, Risk Factors, Cerebrum

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review