Irrational Exuberance in Testosterone Prescribing: When Will the Bubble Burst?
Abstract
ANZAC Research Institute, University of Sydney, Concord Hospital, NSW, Australia D.J.H.’s institution gets pharmaceutical company funding (Besin, Lawley) for investigator-initiated studies in testosterone pharmacology. The author receives no personal income or consultancy fees related to this work. Reprints: David J. Handelsman, MBBS, FRACP, PhD, ANZAC Research Institute, University of Sydney, Concord Hospital, NSW 2139, Australia. E-mail: [email protected].
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Potential contributors to overprescribing of testosterone include commercial advertising and lax definition of hypogonadism by some society guidelines that fails to distinguish true pathological hypogonadism from the mere presence of low testosterone levels.
“Potential contributors to this overprescribing of testosterone include commercial advertising and lax definition of Bhypogonadism^by some society guidelines that fails to distinguish between true pathological hypogonadism (for which testosterone therapy is approved) and the mere presence of low testosterone levels.10”
From Who Gets Testosterone? Patient Characteristics Associated with Testosterone Prescribing in the Veteran Affairs System: a Cross-Sectional Study (2017) · cites this paper as [10]
Cites
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889 · see citing works
Adverse Events Associated with Testosterone Administration
Basaria, S., Coviello, A. D., Travison, T. G., Storer, T. W., Farwell, W. R., Jette, A. M., Eder, R., Tennstedt, S., Ulloor, J., Zhang, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000485 · Cited by 1,494 · see citing works
Vigen, R. (2013) · JAMA · doi:10.1001/jama.2013.280386 · Cited by 1,003 · see citing works
Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men
Finkle, W. D., Greenland, S., Ridgeway, G. K., Adams, J. L., Frasco, M. A., Cook, M. B., Fraumeni, J. F., & Hoover, R. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085805 · Cited by 735 · see citing works
Xu, L., Freeman, G., Cowling, B. J., & Schooling, C. M. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-108 · Cited by 562 · see citing works
Screening for Prostate Cancer With the Prostate-Specific Antigen Test
Hayes, J. H., & Barry, M. J. (2014) · JAMA · doi:10.1001/jama.2014.2085 · Cited by 360 · see citing works
Handelsman, D. J. (2013) · Medical Journal of Australia · doi:10.5694/mja13.10111 · Cited by 253 · see citing works
Self-citationInstitute of Medicine (2004) · National Academies Press eBooks · doi:10.17226/10852 · Cited by 231 · see citing works
Testosterone Replacement Therapy in Patients with Prostate Cancer After Radical Prostatectomy
Pastuszak, A. W., Pearlman, A. M., Lai, W. S., Godoy, G., Sathyamoorthy, K., Liu, J. S., Miles, B. J., Lipshultz, L. I., & Khera, M. (2013) · Journal of Urology · doi:10.1016/j.juro.2013.02.002 · Cited by 183 · see citing works
Seftel, A. D. (2015) · The Journal of Urology · doi:10.1016/j.juro.2015.06.058 · Cited by 131 · see citing works
Comparative Safety of Testosterone Dosage Forms
Layton, J. B., Meier, C. R., Sharpless, J. L., Stürmer, T., Jick, S. S., & Brookhart, M. A. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.1573 · Cited by 96 · see citing works
The nonthyroidal illness syndrome in the non-critically ill patient
Παππά, Θ., Vagenakis, A. G., & Alevizaki, M. K. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02395.x · Cited by 83 · see citing works
Screening and Monitoring in Men Prescribed Testosterone Therapy in the U.S., 2001–2010
Baillargeon, J., Urban, R. J., Kuo, Y.-F., Holmes, H. M., Raji, M. A., Morgentaler, A., Howrey, B. T., Lin, Y.-L., & Ottenbacher, K. J. (2015) · Public Health Reports® · doi:10.1177/003335491513000207 · Cited by 61 · see citing works
Ascertainment of Testosterone Prescribing Practices in the VA
Jasuja, G. K., Bhasin, S., Reisman, J. I., Berlowitz, D. R., & Rose, A. J. (2015) · Medical Care · doi:10.1097/mlr.0000000000000398 · Cited by 51 · see citing works
Kaplan, A. L., Trinh, Q., Sun, M., Carter, S. C., Nguyen, P. L., Shih, Y. T., Marks, L. S., & Hu, J. C. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12429 · Cited by 49 · see citing works
Trends and regional differences in testosterone prescribing in Australia, 1991–2001
Handelsman, D. J. (2004) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2004.tb06364.x · Cited by 48 · see citing works
Self-citationDisease Mongering of Age‐Associated Declines in Testosterone and Growth Hormone Levels
Perls, T. T., & Handelsman, D. J. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13391 · Cited by 47 · see citing works
Self-citationA comparative quality assessment of evidence‐based clinical guidelines in endocrinology
Hazlehurst, J., Armstrong, M. J., Sherlock, M., Rowe, I. A. C., O’Reilly, M., Franklyn, J. A., Stewart, P. M., & Tomlinson, J. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04441.x · Cited by 44 · see citing works
Braun, S. R. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.6892 · Cited by 42 · see citing works
Testosterone Replacement Therapy Faces FDA Scrutiny
Garnick, M. B. (2014) · JAMA · doi:10.1001/jama.2014.17334 · Cited by 37 · see citing works
The Impact of Drug Reimbursement Policy on Rates of Testosterone Replacement Therapy among Older Men
Piszczek, J., Mamdani, M., Antoniou, T., Juurlink, D. N., & Gomes, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098003 · Cited by 34 · see citing works
Walsh, T. J., Shores, M. M., Fox, A., Moore, K. P., Forsberg, C. W., Kinsey, C. E., Heckbert, S. R., Zeliadt, S. B., Thompson, M. L., Smith, N. L., et al. (2015) · Andrology · doi:10.1111/andr.12014 · Cited by 26 · see citing works
Population‐based patterns of prescription androgen use, 1976–2008
Hall, S. A., Ranganathan, G., TINSLEY, L. J., Lund, J. L., Kupelian, V. A., Wittert, G., Kantoff, P. W., Morales, Á., & de Araújo, A. B. (2014) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3579 · Cited by 19 · see citing works
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Self-citationJasuja, G. K., Bhasin, S., Reisman, J. I., Hanlon, J. T., Miller, D. R., Morreale, A. P., Pogach, L. M., Cunningham, F. E., Park, A., Berlowitz, D. R., et al. (2017) · Journal of General Internal Medicine · doi:10.1007/s11606-016-3940-7 · Cited by 44 · see citing works
- Authors
- Handelsman, D. J.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Handelsman, David J.
- ORCID
- Handelsman, David J.
- Venue
- Medical Care
- Published
- 2015-09
- Volume
- 53
- Issue
- 9
- Pages
- 743-745
- ISSN
- 0025-7079 (ISSN-L)
- OpenAlex
- W2465824810
- Cited by
- 22
- References
- 23
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2017: 8 · 2016: 3
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Health Professions › General Health Professions › Healthcare cost, quality, practices
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- irrational prescribing, testosterone replacement therapy, pharmaceutical industry influence
- MeSH terms
- Humans, Male, Practice Patterns, Physicians', Testosterone, United States Department of Veterans Affairs
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