The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Redox signaling, Nox5 and vascular remodeling in hypertension
Open accessAbstract
PURPOSE OF REVIEW: Extensive data indicate a role for reactive oxygen species (ROS) and redox signaling in vascular damage in hypertension. However, molecular mechanisms underlying these processes remain unclear, but oxidative post-translational modification of vascular proteins is critical. This review discusses how proteins are oxidatively modified and how redox signaling influences vascular smooth muscle cell growth and vascular remodeling in hypertension. We also highlight Nox5 as a novel vascular ROS-generating oxidase. RECENT FINDINGS: Oxidative stress in hypertension leads to oxidative imbalance that affects vascular cell function through redox signaling. Many Nox isoforms produce ROS in the vascular wall, and recent findings show that Nox5 may be important in humans. ROS regulate signaling by numerous processes including cysteine oxidative post-translational modification such as S-nitrosylation, S-glutathionylation and sulfydration. In vascular smooth muscle cells, this influences cellular responses to oxidative stimuli promoting changes from a contractile to a proliferative phenotype. SUMMARY: In hypertension, Nox-induced ROS production is increased, leading to perturbed redox signaling through oxidative modifications of vascular proteins. This influences mitogenic signaling and cell cycle regulation, leading to altered cell growth and vascular remodeling in hypertension.
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“NOX5 expression can be activated by most of the factors that activate other vascular NOX enzymes such as angiotensin II, TNF-α, PDGF, thrombin, and endothelin-1 (81, 660, 681).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [660]
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Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis
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Metadata
- Authors
- Montezano, A. C., Tsiropoulou, S., Dulak-Lis, M., Harvey, A., Camargo, L. D. L., & Touyz, R. M.
- Affiliations
- University of Glasgow (GB)
- Corresponding author
- Touyz, Rhian M.
- Venue
- Current Opinion in Nephrology and Hypertension
- Published
- 2015-09
- Volume
- 24
- Issue
- 5
- Pages
- 425-433
- ISSN
- 1062-4821 (ISSN-L)
- PMC
- PMC4727501
- OpenAlex
- W955847907
- Cited by
- 93
- References
- 92
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 14 · 2019: 14 · 2018: 10 · 2017: 15 · 2016: 10
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Nephrology & Hypertension (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Funders
- British Heart Foundation (29762, RG/13/7/30099, 30099)
- Canadian Institutes of Health Research (44018, 57786)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- redox signaling, NADPH oxidase 5, reactive oxygen species, hypertension, vascular remodeling, oxidative post-translational modifications, S-nitrosylation, S-glutathionylation, cysteine oxidation, vascular smooth muscle cells, oxidative stress, NADPH oxidase, vascular cell proliferation
- MeSH terms
- NADPH Oxidase 5, Animals, Humans, Hypertension, Membrane Proteins, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species, NADPH Oxidases, Vascular Remodeling
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