Cited by 93Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

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Redox signaling, Nox5 and vascular remodeling in hypertension

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Montezano, Augusto C., Tsiropoulou, Sofia, Dulak-Lis, Maria, Harvey, Adam, Camargo, Livia De Lucca, Touyz, Rhian M.·2015·Current Opinion in Nephrology and Hypertension

DOI 10.1097/mnh.0000000000000153PMC PMC4727501

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Abstract

PURPOSE OF REVIEW: Extensive data indicate a role for reactive oxygen species (ROS) and redox signaling in vascular damage in hypertension. However, molecular mechanisms underlying these processes remain unclear, but oxidative post-translational modification of vascular proteins is critical. This review discusses how proteins are oxidatively modified and how redox signaling influences vascular smooth muscle cell growth and vascular remodeling in hypertension. We also highlight Nox5 as a novel vascular ROS-generating oxidase. RECENT FINDINGS: Oxidative stress in hypertension leads to oxidative imbalance that affects vascular cell function through redox signaling. Many Nox isoforms produce ROS in the vascular wall, and recent findings show that Nox5 may be important in humans. ROS regulate signaling by numerous processes including cysteine oxidative post-translational modification such as S-nitrosylation, S-glutathionylation and sulfydration. In vascular smooth muscle cells, this influences cellular responses to oxidative stimuli promoting changes from a contractile to a proliferative phenotype. SUMMARY: In hypertension, Nox-induced ROS production is increased, leading to perturbed redox signaling through oxidative modifications of vascular proteins. This influences mitogenic signaling and cell cycle regulation, leading to altered cell growth and vascular remodeling in hypertension.

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Yang, G., Wu, L., Jiang, B., Yang, W., Qi, J., Cao, K., Meng, Q., Mustafa, A. K., Mu, W., Zhang, S., et al. (2008) · Science · doi:10.1126/science.1162667 · Cited by 2,310
Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases
Fukai, T., & Ushio‐Fukai, M. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3999 · Cited by 2,074
Superoxide Anion Radical (O·̄2), Superoxide Dismutases, and Related Matters
Fridovich, I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18515 · Cited by 1,337
Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant
Heumüller, S., Wind, S., Barbosa-Sicard, E., Schmidt, H. H. H. W., Busse, R., Schröder, K., & Brandes, R. P. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.100214 · Cited by 735
Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.
Rao, G. N., & Berk, B. C. (1992) · Circulation Research · doi:10.1161/01.res.70.3.593 · Cited by 649
Molecular Mechanisms and Clinical Implications of Reversible Protein S -Glutathionylation
Mieyal, J. J., Gallogly, M. M., Qanungo, S., Sabens, E. A., & Shelton, M. D. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2089 · Cited by 523
Evolution of nadph oxidase inhibitors: Selectivity and mechanisms for target engagement
Altenhöfer, S., Radermacher, K. A., Kleikers, P. W. M., Wingler, K., & Schmidt, H. H. H. W. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5814 · Cited by 521
Regulation of Signal Transduction by Reactive Oxygen Species in the Cardiovascular System
Brown, D., & Griendling, K. K. (2015) · Circulation Research · doi:10.1161/circresaha.116.303584 · Cited by 498
NADPH Oxidases in Vascular Pathology
Konior, A., Schramm‐Luc, A., Cześnikiewicz‐Guzik, M., & Guzik, T. J. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5607 · Cited by 464
H 2 S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response
Krishnan, N., Fu, C., Pappin, D., & Tonks, N. K. (2011) · Science Signaling · doi:10.1126/scisignal.2002329 · Cited by 455
Angiotensin II and Vascular Injury
Montezano, A. C. I., Cat, A. N. D., Rios, F. J. O., & Touyz, R. M. (2014) · Current Hypertension Reports · doi:10.1007/s11906-014-0431-2 · Cited by 412
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Chen, X., Touyz, R. M., Park, J. B., & Schiffrin, E. L. (2001) · Hypertension · doi:10.1161/hy09t1.094005 · Cited by 410
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Dalle‐Donne, I. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00749-3 · Cited by 398
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Thomas, S. R., Witting, P. K., & Drummond, G. R. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2027 · Cited by 383
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Go, Y., Chandler, J. D., & Jones, D. P. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.022 · Cited by 363
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Mangge, H. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i6.462 · Cited by 347
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Schiffrin, E. L. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.05.023 · Cited by 334
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Drummond, G. R., & Sobey, C. G. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.06.012 · Cited by 315
Cysteine Oxidative Posttranslational Modifications
Chung, H. S., Wang, S.-B., Venkatraman, V., Murray, C. I., & Eyk, J. E. V. (2013) · Circulation Research · doi:10.1161/circresaha.112.268680 · Cited by 314
Calcium-Dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease
Guzik, T. J., Chen, W., Gongora, M. C., Guzik, B., Lob, H. E., Mangalat, D., Hoch, N., Dikalov, S., Rudzinski, P., Kapelak, B., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.07.063 · Cited by 281
Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research
Montezano, A. C. I., & Touyz, R. M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5302 · Cited by 280
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Greco, T. M., Hodara, R., Parastatidis, I., Heijnen, H. F. G., Dennehy, M. K., Liebler, D. C., & Ischiropoulos, H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600729103 · Cited by 259
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Ghouleh, I. A., Khoo, N. K. H., Knaus, U. G., Griendling, K. K., Touyz, R. M., Thannickal, V. J., Barchowsky, A., Nauseef, W. M., Kelley, E. E., Bauer, P. M., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.011 · Cited by 252
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Reactive oxygen species and redox compartmentalization
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Dikalov, S., & Ungvari, Z. I. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00089.2013 · Cited by 205
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Self-citation
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Montezano, A. C., Burger, D., Paravicini, T. M., Chignalia, A. Z., Yusuf, H., Almasri, M., He, Y., Callera, G. E., He, G., Krause, K.-H., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.216036 · Cited by 188
Self-citation
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Wang, S.-B., Foster, D. B., Rucker, J. J., O'Rourke, B. P., Kass, D. A., & Eyk, J. E. V. (2011) · Circulation Research · doi:10.1161/circresaha.111.246124 · Cited by 166
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Barnouin, K., Dubuisson, M., Child, E. S., de Mattos, S. F., Glassford, J., Medema, R. H., Mann, D. J., & Lam, E. W. ‐. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111123200 · Cited by 161
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Fulton, D. J. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2587 · Cited by 161
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Canton, M., Menazza, S., Sheeran, F. L., de Laureto, P. P., Lisa, F. D., & Pepe, S. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.06.058 · Cited by 159
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Zweier, J. L., Chen, C., & Druhan, L. J. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3904 · Cited by 147
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SERRANDER, L., JAQUET, V, BEDARD, K., PLASTRE, O., HARTLEY, O., ARNAUDEAU, S., DEMAUREX, N., SCHLEGEL, W., & KRAUSE, K. (2007) · Biochimie · doi:10.1016/j.biochi.2007.05.004 · Cited by 146
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Santos, C. X. C., Nabeebaccus, A., Shah, A. M., Camargo, L. L., Filho, S. V., & Lopes, L. R. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5262 · Cited by 143
Self-citation
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Oelze, M. W., Kröller‐Schön, S., Steven, S., Lubos, E., Doppler, C. E. J., Hausding, M., Tobias, S., Brochhausen, C., Li, H., Torzewski, M., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01602 · Cited by 136
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Holterman, C. E., Thibodeau, J.-F., Towaij, C., Gutsol, A. A., Montezano, A. C. I., Parks, R. J., Cooper, M. E., Touyz, R. M., & Kennedy, C. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013040371 · Cited by 133
Self-citation
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Bedard, K., Jaquet, V., & Krause, K. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.023 · Cited by 126
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Barman, S. A., Chen, F., Su, Y., Dimitropoulou, C., Wang, Y., Catravas, J. D., Han, W., Őrfi, L., Szántai-Kis, C., Kéri, G., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303848 · Cited by 124
Effect of vitamin C and vitamin E supplementation on endothelial function: a systematic review and meta-analysis of randomised controlled trials
Ashor, A. W., Siervo, M., Lara, J., Oggioni, C., Afshar, S., & Mathers, J. C. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515000227 · Cited by 112
Redox-dependent MAP kinase signaling by Ang II in vascular smooth muscle cells: role of receptor tyrosine kinase transactivation
Touyz, R. M., Cruzado, M., Tabet, F., Yao, G., Salomon, S., & Schiffrin, E. L. (2003) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y02-164 · Cited by 109
Self-citation
Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl
Jamali, A. E., Valente, A. J., Lechleiter, J. D., Gamez, M. J., Pearson, D. W., Nauseef, W. M., & Clark, R. A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.11.020 · Cited by 107
Redox Regulation of Protein Kinases as a Modulator of Vascular Function
Knock, G. A., & Ward, J. P. T. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3614 · Cited by 107
Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models
Rivera, J., Sobey, C. G., Walduck, A. K., & Drummond, G. R. (2010) · Redox Report · doi:10.1179/174329210x12650506623401 · Cited by 105
Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation
Qian, J., Chen, F., Kovalenkov, Y. O., Pandey, D., Moseley, M. A., Foster, M. W., Black, S. M., Venema, R. C., Stepp, D. W., & Fulton, D. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.029 · Cited by 100
Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases.
Kyaw, M. H., Yoshizumi, M., Tsuchiya, K., Izawa, Y., Kanematsu, Y., & Tamaki, T. (2004) · PubMed · Cited by 96
NADPH oxidase inhibitors: a decade of discovery from Nox2ds to HTS
Cifuentes-Pagano, E., Csányi, G., & Pagano, P. J. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1009-2 · Cited by 94
Regulation of NADPH Oxidase 5 by Protein Kinase C Isoforms
Chen, F., Yu, Y., Haigh, S., Johnson, J. A., Lucas, R., Stepp, D. W., & Fulton, D. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088405 · Cited by 89
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Briones, A. M., Tabet, F., Callera, G. E., Montezano, A. C. I., Yogi, Á., He, Y., Quinn, M. T., Salaíces, M., & Touyz, R. M. (2011) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2011.02.001 · Cited by 89
Self-citation
Autophagic regulation of smooth muscle cell biology
Salabei, J. K., & Hill, B. G. (2014) · Redox Biology · doi:10.1016/j.redox.2014.12.007 · Cited by 86
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Brandes, R. P., Weißmann, N., & Schröder, K. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5414 · Cited by 84
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Cifuentes-Pagano, E., Meijles, D. N., & Pagano, P. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5620 · Cited by 84
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Mackay, C., & Knock, G. A. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.285304 · Cited by 84
Hsp90 Regulates NADPH Oxidase Activity and Is Necessary for Superoxide but Not Hydrogen Peroxide Production
Chen, F., Pandey, D., Chadli, A., Catravas, J. D., Chen, T., & Fulton, D. J. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3669 · Cited by 81
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Pandey, D., Patel, A., Patel, V., Chen, F., Qian, J., Wang, Y., Barman, S. A., Venema, R. C., Stepp, D. W., Daniel Rudic, R., et al. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00910.2011 · Cited by 81
Targeting NOX enzymes in the central nervous system: therapeutic opportunities
Sorce, S., Krause, K., & Jaquet, V. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1014-5 · Cited by 79
S-glutathionylation in human platelets by a thiol–disulfide exchange-independent mechanism
Dalle‐Donne, I., Giustarini, D., Colombo, R., Milzani, A., & Rossi, R. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.019 · Cited by 76
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Raaz, U., Toh, R., Mäegdefessel, L., Adam, M., Nakagami, F., Emrich, F. C., Spin, J. M., & Tsao, P. S. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5507 · Cited by 76
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Manea, A., Manea, S.-A., Gan, A. M., Constantin, A., Fenyo, I. M., Raicu, M., Muresian, H., & Simionescu, M. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.04.021 · Cited by 69
Small artery remodeling in hypertension and diabetes
Rizzoni, D., & Rosei, E. A. (2006) · Current Hypertension Reports · doi:10.1007/s11906-006-0046-3 · Cited by 69
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Hahn, N. E., Meischl, C., Kawahara, T., Musters, R. J. P., Verhoef, V. M. J., van der Velden, J., Vonk, A. B. A., Paulus, W. J., van Rossum, A. C., Niessen, H. W. M., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.02.018 · Cited by 67
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Murray, C. I., Kane, L. A., Uhrigshardt, H., Wang, S.-B., & Van Eyk, J. E. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.004721 · Cited by 63
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Kim, M., Ham, O., Lee, S., Choi, E., Lee, C. Y., Park, J., Lee, J., Seo, H., Seung, M., Choi, E., et al. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24841 · Cited by 57
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Lee, S. E., & Park, Y. S. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/629028 · Cited by 56
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Pandey, D., & Fulton, D. J. R. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01163.2010 · Cited by 55
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Liu, B., Luo, X., Yang, Z., Zhang, J.-J., Li, T., Zhang, X., Ma, Q., Zhang, G., Hu, C., & Peng, J. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000082 · Cited by 54
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Yu, P., Han, W., Villar, V. A. M., Yang, Y., Lu, Q., Lee, H., Li, F., Quinn, M. T., Gildea, J. J., Felder, R. A., et al. (2014) · Redox Biology · doi:10.1016/j.redox.2014.01.020 · Cited by 53
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Tousoulis, D., Ψαλτοπούλου, Θ., Androulakis, E. S., Παπαγεωργίου, Ν., Papaioannou, S., Oikonomou, E. K., Synetos, A. G., & Stefanadis, C. (2014) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-014-6562-5 · Cited by 51
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Self-citation
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Redox Regulation of Actin by Thioredoxin-1 Is Mediated by the Interaction of the Proteins via Cysteine 62
Wang, X., Ling, S., Zhao, D., et al. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2833 · Cited by 34
Antioxidant Treatment Prevents Serum Deprivation- and TNF-α-Induced Endothelial Dysfunction through the Inhibition of NADPH Oxidase 4 and the Restoration of β-Oxidation
Scioli, M. G., Bielli, A., Agostinelli, S., Tarquini, C., Arcuri, G., Ferlosio, A., Costanza, G., Doldo, E., & Orlandi, A. (2014) · Journal of Vascular Research · doi:10.1159/000365926 · Cited by 32
Antioxidant Vitamin Intake and Mortality
Paganini‐Hill, A., Kawas, C. H., & Corrada, M. M. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu294 · Cited by 29
Protein disulfide isomerase expression increases in resistance arteries during hypertension development. Effects on Nox1 NADPH oxidase signaling
Androwiki, A. C. D., Camargo, L. L., Sartoretto, S., Couto, G. K., Ribeiro, I. M. R., Veríssimo-Filho, S., Rossoni, L. V., & Lopes, L. R. (2015) · Frontiers in Chemistry · doi:10.3389/fchem.2015.00024 · Cited by 25
Self-citation
IL-22 activates oxidant signaling in pulmonary vascular smooth muscle cells
Bansal, G., Das, D., Hsieh, C., Wang, Y., Gilmore, B. A., Wong, C., & Suzuki, Y. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.09.001 · Cited by 24
Interferon regulatory factor-1 together with reactive oxygen species promotes the acceleration of cell cycle progression by up-regulating the cyclin E and CDK2 genes during high glucose-induced proliferation of vascular smooth muscle cells
Zhang, X., Liu, L., Chen, C., et al. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-147 · Cited by 24
Inhibition of NAD(P)H oxidase potentiates AT2 receptor agonist-induced natriuresis in Sprague-Dawley rats
Sabuhi, R., Asghar, M., & Hussain, T. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00310.2010 · Cited by 19
NADPH Oxidases: Progress and Opportunities
Martín, A. S., & Griendling, K. K. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5947 · Cited by 16
Recombinant human prothrombin kringle-2 induces bovine capillary endothelial cell cycle arrest at G0–G1 phase through inhibition of cyclin D1/CDK4 complex: Modulation of reactive oxygen species generation and up-regulation of cyclin-dependent kinase inhibitors
Kim, T. H., Oh, S. V., & Kim, S. S. (2006) · Angiogenesis · doi:10.1007/s10456-005-9020-y · Cited by 16
Ascorbic Acid Levels and Neutrophil Superoxide Production in Blood of Pre-, Early and Late Hypertensive Stroke-Prone Spontaneously Hypertensive Rats
Sato, Y., Ikeda, M., Ito, T., Tomita, T., Yokotani, K., Murata, M., & Umegaki, K. (2011) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2010.549268 · Cited by 4

Research works printed but not linked: 3

Lee, 2013, Oxid Med Cell Longev, 2013, 629028
Drummond, 2014, etab, 25, 452
Yoshizumi, 2004, Acta Pharmacol Sin, 25, 977

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Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541

See all 93

Authors: Montezano, A. C., Tsiropoulou, S., Dulak-Lis, M., Harvey, A., Camargo, L. D. L., & Touyz, R. M.
Affiliations: University of Glasgow (GB)
Corresponding author: Touyz, Rhian M.
ORCID: Montezano, Augusto C.
Tsiropoulou, Sofia
Harvey, Adam
Touyz, Rhian M.
Venue: Current Opinion in Nephrology and Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-09
Volume: 24
Issue: 5
Pages: 425-433
ISSN: 1062-4821 (ISSN-L)
DOI: 10.1097/mnh.0000000000000153
PMC: PMC4727501
OpenAlex: W955847907
Cited by: 93
References: 92
Citations by year: 2026: 2 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 14 · 2019: 14 · 2018: 10 · 2017: 15 · 2016: 10
FWCI: 1.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Current Opinion in Nephrology & Hypertension (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
Funders: British Heart Foundation (29762, RG/13/7/30099, 30099)
Canadian Institutes of Health Research (44018, 57786)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: redox signaling, NADPH oxidase 5, reactive oxygen species, hypertension, vascular remodeling, oxidative post-translational modifications, S-nitrosylation, S-glutathionylation, cysteine oxidation, vascular smooth muscle cells, oxidative stress, NADPH oxidase, vascular cell proliferation
MeSH terms: NADPH Oxidase 5, Animals, Humans, Hypertension, Membrane Proteins, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species, NADPH Oxidases, Vascular Remodeling

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Redox signaling, Nox5 and vascular remodeling in hypertension

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