Intestinal phospholipid and lysophospholipid metabolism in cardiometabolic disease

Prevalence of Childhood and Adult Obesity in the United States, 2011-2012

Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2014) · JAMA · doi:10.1001/jama.2014.732 · Cited by 8,072 · see citing works

Linking long-term dietary patterns with gut microbial enterotypes

Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

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Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386 · see citing works

The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis

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Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk

Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,402 · see citing works

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915 · see citing works

High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity

Hildebrandt, M. A., Hoffmann, C., Sherrill–Mix, S. A., Keilbaugh, S. A., Hamady, M., Chen, Y., Knight, R., Ahima, R. S., Bushman, F., & Wu, G. D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.042 · Cited by 1,576 · see citing works

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

Seldin, M. M., Meng, Y., Qi, H., Zhu, W., Wang, Z., Hazen, S. L., Lusis, A. J., & Shih, D. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002767 · Cited by 911 · see citing works

Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- <i>N</i> -Oxide

Romano, K. A., Vivas, E. I., Amador-Noguez, D., & Rey, F. E. (2015) · mBio · doi:10.1128/mbio.02481-14 · Cited by 777 · see citing works

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

Gregory, J. C., Buffa, J. A., Org, E., Wang, Z., Levison, B. S., Zhu, W., Wagner, M. A., Bennett, B. J., Li, L., DiDonato, J. A., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.618249 · Cited by 486 · see citing works

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

Miao, J., Ling, A. V., Manthena, P. V., Gearing, M. E., Graham, M. J., Crooke, R. M., Croce, K. J., Esquejo, R. M., Clish, C. B., Morbid Obesity Study Group, et al. (2015) · Nature Communications · doi:10.1038/ncomms7498 · Cited by 368 · see citing works

Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet

Gao, X., Liu, X., Xu, J., Xue, C., Xue, Y., & Wang, Y. (2014) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2014.03.001 · Cited by 360 · see citing works

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

Shih, D. M., Wang, Z., Lee, R., Meng, Y., Che, N., Charugundla, S., Qi, H., Wu, J., Pan, C., Brown, J. M., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m051680 · Cited by 335 · see citing works

Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure

Tang, W. H. W., Wang, Z., Shrestha, K., Borowski, A. G., Wu, Y., Troughton, R. W., Klein, A. L., & Hazen, S. L. (2015) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2014.11.006 · Cited by 325 · see citing works

Lysoglycerophospholipids in chronic inflammatory disorders: The PLA2/LPC and ATX/LPA axes

Sevastou, I. G., Kaffe, E., Mouratis, M.-A., & Aidinis, V. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.07.019 · Cited by 242 · see citing works

Autotaxin Is Released from Adipocytes, Catalyzes Lysophosphatidic Acid Synthesis, and Activates Preadipocyte Proliferation

Ferry, G., Tellier, E., Renouard-Try, A., Grès, S., Naime, I., Simon, M., Rodriguez, M., Boucher, J., Tack, I., Gesta, S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301158200 · Cited by 230 · see citing works

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

Rong, X., Wang, B., Dunham, M. M., Hedde, P. N., Wong, J. S., Gratton, E., Young, S. G., Ford, D. A., & Tontonoz, P. (2015) · eLife · doi:10.7554/elife.06557 · Cited by 228 · see citing works

Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid

Dusaulcy, R., Rancoule, C., Grès, S., Wanecq, E., Colom, A., Guigné, C., van Meeteren, L. A., Moolenaar, W. H., Valet, P., & Saulnier‐Blache, J. S. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m014985 · Cited by 183 · see citing works

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet

Wang, B., Rong, X., Duerr, M. A., Hermanson, D. J., Hedde, P. N., Wong, J. S., Vallim, T. Q. D. A., Cravatt, B. F., Gratton, E., Ford, D. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.001 · Cited by 130 · see citing works

Drug treatment of obesity: Current status and future prospects

Kakkar, A. K., & Dahiya, N. (2015) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2015.01.005 · Cited by 113 · see citing works

Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression

Boucher, J., Quilliot, D., Prad�res, J. P., et al. (2005) · Diabetologia · doi:10.1007/s00125-004-1660-8 · Cited by 103 · see citing works

Studies on plasma lipoproteins during absorption of exogenous lecithin in man.

Beil, F. U., & Grundy, S. M. (1980) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42223-0 · Cited by 102 · see citing works

Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A2–Deficient mice

Richmond, B. L., Boileau, A. C., Zheng, S., Huggins, K. W., Granholm, N. A., Tso, P., & Hui, D. Y. (2001) · Gastroenterology · doi:10.1053/gast.2001.23254 · Cited by 98 · see citing works

ENPP2 Contributes to Adipose Tissue Expansion and Insulin Resistance in Diet-Induced Obesity

Nishimura, S., Nagasaki, M., Okudaira, S., Aoki, J., Ohmori, T., Ohkawa, R., Nakamura, K., Igarashi, K., Yamashita, H., Eto, K., et al. (2014) · Diabetes · doi:10.2337/db13-1694 · Cited by 96 · see citing works

A novel approach to oral apoA-I mimetic therapy

Chattopadhyay, A., Navab, M., Hough, G., Gao, F., Meriwether, D., Grijalva, V. R., Springstead, J. R., Palgnachari, M. N., Namiri‐Kalantari, R., Su, F., et al. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m033555 · Cited by 92 · see citing works

Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice

Rancoule, C., Attané, C., Grès, S., Fournel, A., Dusaulcy, R., Bertrand, C., Vinel, C., Tréguer, K., Prentki, M., Valet, P., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2891-3 · Cited by 89 · see citing works

Phospholipase A2 enzymes in metabolic and cardiovascular diseases

Hui, D. Y. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328351b439 · Cited by 85 · see citing works

Deficiency in Lysophosphatidylcholine Acyltransferase 3 Reduces Plasma Levels of Lipids by Reducing Lipid Absorption in Mice

Li, Z., Jiang, H., Ding, T., Lou, C., Bui, H. H., Kuo, M., & Jiang, X. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.012 · Cited by 84 · see citing works

Non-Systemic Drugs: A Critical Review

Charmot, D. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799504858 · Cited by 81 · see citing works

Autotaxin and Its Product Lysophosphatidic Acid Suppress Brown Adipose Differentiation and Promote Diet-Induced Obesity in Mice

Federico, L., Ren, H., Mueller, P. A., Wu, T., Liu, S., Popović, J., Blalock, E. M., Sunkara, M., Ovaa, H., Albers, H. M. H. G., et al. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1229 · Cited by 69 · see citing works

Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid

Navab, M., Hough, G., Buga, G. M., Su, F., Wagner, A. C., Meriwether, D., Chattopadhyay, A., Gao, F., Grijalva, V. R., Danciger, J. S., et al. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m042051 · Cited by 69 · see citing works

Arguing the Case for the Autotaxin–Lysophosphatidic Acid–Lipid Phosphate Phosphatase 3-Signaling Nexus in the Development and Complications of Atherosclerosis

Smyth, S. S., Müeller, P., Yang, F., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302737 · Cited by 66 · see citing works

Source and role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis

Navab, M., Chattopadhyay, A., Hough, G., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m056614 · Cited by 51 · see citing works

Identification of Functional Domains of Rat Intestinal Phospholipase B/Lipase

Takemori, H., Zolotaryov, F. N., Lü, T., Tchoua, U., Komatsubara, T., Hatano, O., Okamoto, M., & Tojo, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.2222 · Cited by 48 · see citing works

Small Intestine but Not Liver Lysophosphatidylcholine Acyltransferase 3 (Lpcat3) Deficiency Has a Dominant Effect on Plasma Lipid Metabolism

Kabir, I., Li, Z., Bui, H. H., Kuo, M., Gao, G., & Jiang, X. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.697011 · Cited by 41 · see citing works

Dietary and biliary phosphatidylcholine activates PKCζ in rat intestine

Siddiqi, S. A., & Mansbach, C. M. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m056051 · Cited by 27 · see citing works

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

Janeiro, M., Ramírez, M., Milagro, F., Martínez, J., & Solas, M. (2018) · Nutrients · doi:10.3390/nu10101398 · Cited by 631 · see citing works

Lysophospholipase D/Autotaxin in Lysophospholipid Biology

Im, D. (2007) · Current Enzyme Inhibition · doi:10.2174/157340807779815440

The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer

Magkrioti, C., Kaffe, E., & Aidinis, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098325 · Cited by 14 · see citing works

Crystal Structure of Autotaxin, a Lysophospholipase D that Produces Lipid Mediator Lysophosphatidic Acids

Nishimasu, H., Takagi, J., Aoki, J., et al. (2011) · Nihon Kessho Gakkaishi · doi:10.5940/jcrsj.53.207

Controlling cancer through the autotaxin–lysophosphatidic acid receptor axis

Gotoh, M., Fujiwara, Y., Yue, J., et al. (2012) · Biochemical Society Transactions · doi:10.1042/bst20110608 · Cited by 107 · see citing works

Measurement of lysophospholipase D/autotaxin activity in human serum samples

Nakamura, K., Ohkawa, R., Okubo, S., et al. (2006) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2006.10.009 · Cited by 62 · see citing works