Adolescent and young adult cancers: unmet needs and closing the gaps
Open accessAbstract
Purpose of review: There is a growing population of adolescent and young adult (AYA, ages 15–39 years) cancer patients and survivors, and the field of AYA oncology is rapidly evolving. Despite an increased focus on survival and quality of life for AYAs, gaps in knowledge remain. The current review focuses on what is known across several domains unique to AYA cancer care as well as areas of improvement and future directions in research and intervention. Recent findings: Due to the developmental stages included in the AYA age range, a cancer diagnosis and treatment can affect relationships, education and employment, finances, and long-term health differently than diagnoses in younger or older populations. Recent studies that have focused on these unique aspects of AYA cancer care, including health-related quality of life (HRQoL), fertility, financial toxicity, barriers to clinical trial enrollment, genetic predisposition, and survivorship care are included in the current review. Summary: Although studies have described many of the challenges faced by AYAs across the cancer continuum from diagnosis to survivorship, more work is needed, particularly in systematically measuring HRQoL, eliminating barriers to clinical trial enrollment, addressing financial toxicity, and increasing access to fertility preservation and high-quality survivorship care.
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Young adult cancer survivors face physical, mental, social, educational, occupational, and financial consequences from cancer and its treatment.
“their survivorship journey entails managing the physical and mental health, social, educational, occupational, and financial consequences of cancer diagnosis and treatment [2-6].”
There is a pressing need for interventions addressing YA survivors' psychosocial concerns to enhance quality of life across the lifespan.
“Given the increasing number of YA survivors [1] and the impacts of cancer across various aspects of life, particularly among YAs [2-6, 8], there is a pressing need for interventions addressing YA survivors’ psychosocial concerns in order to enhance quality of life across the lifespan [7].”
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- [25]Benedict C, Shuk E, Ford JS. Fertility issues in adolescent and young adult cancer survivors. J Adolesc Young Adult Oncol 2016; 5: 48– 57. 26812452 PMC4779291
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- Authors
- Berkman, A. M., Mittal, N., & Roth, M. E.
- Affiliations
- Duke University (US)
- Rush University Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Berkman, Amy M.
- Mittal, Nupur
- Venue
- Current Opinion in Pediatrics
- Published
- 2022-11-11
- Volume
- 35
- Issue
- 1
- Pages
- 84-90
- ISSN
- 1040-8703 (ISSN-L)
- 1531-698X
- PMC
- PMC12859744
- OpenAlex
- W4313431081
- Cited by
- 50
- References
- 58
- Citations by year
- 2026: 17 · 2025: 15 · 2024: 9 · 2023: 9
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R38HL143612)
- National Cancer Institute (P30CA016672)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Keywords
- adolescent and young adult cancer, cancer survivors, health-related quality of life, fertility preservation, financial toxicity, genetic susceptibility, survivorship care
- MeSH terms
- Adolescent, Adult, Humans, Neoplasms, Quality of Life, Survivors, Young Adult, Fertility Preservation
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