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Cited by 65Childhood Cancer Survivors' Quality of LifeMultiple and Secondary Primary CancersCancer survivorship and care

The Burden of Late Effects and Related Risk Factors in Adolescent and Young Adult Cancer Survivors: A Scoping Review

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Ryder-Burbidge, Charlotte, Diaz, Ruth L., Barr, Ronald D., Gupta, Sumit, Nathan, Paul C., McKillop, Sarah J., Fidler-Benaoudia, Miranda M.·2021·Cancers
DOI 10.3390/cancers13194870PMC PMC8508204
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Abstract

Risk factors associated with late effects in survivors of adolescent and young adult (AYA) cancer are poorly understood. We conducted a systematic scoping review to identify cohort studies published in English from 2010–2020 that included: (1) cancer survivors who were AYAs (age 15–39 years) at diagnosis and (2) outcomes of subsequent malignant neoplasms (SMNs), chronic conditions, and/or late mortality (>5 years postdiagnosis). There were 652 abstracts identified and, ultimately, 106 unique studies were included, of which 23, 34, and 54 studies related to the risk of SMNs, chronic conditions, and mortality, respectively. Studies investigating late effects among survivors of any primary cancer reported that AYA cancer survivors were at higher risk of SMN, chronic conditions, and all-cause mortality compared to controls. There was an indication that the following factors increased risk: radiation exposure (n = 3) for SMNs; younger attained age (n = 4) and earlier calendar period of diagnosis (n = 3) for chronic conditions; and non-Hispanic Black or Hispanic (n = 5), low socioeconomic status (n = 3), and earlier calendar period of diagnosis (n = 4) for late mortality. More studies including the full AYA age spectrum, treatment data, and results stratified by age, sex, and cancer type are needed to advance knowledge about late effects in AYA cancer survivors.

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  • Physical symptoms and emotional distress contribute to significant social, economic, and health burdens for young adult cancer survivors.

    “Consequently, physical symptoms and emotional distress contribute to significant social, economic, and health burdens for YA at a time when they should otherwise be on an upward social, economic, and health trajectory [18–22].”

    From Improving symptom management for survivors of young adult cancer: rationale and study protocol for a pilot randomized controlled trial (2024) · cites this paper as [19]

    The Discussion says late effects can exacerbate challenges involving social relationships, careers, education, and limited financial resources, and reports a high burden of negative health outcomes. The Results (§3.2) document chronic conditions and mental-health morbidity. The review does not establish that physical symptoms and emotional distress specifically cause the claimed social and economic burdens, and it frames the effect of late effects on those challenges as a possibility. (LLM, conf=0.84)

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Authors
Ryder-Burbidge, C., Diaz, R. L., Barr, R. D., Gupta, S., Nathan, P. C., McKillop, S. J., & Fidler-Benaoudia, M. M.
Affiliations
  • Cancer Care Alberta, Alberta Health Services, Holy Cross Centre, Department of Cancer Epidemiology and Prevention Research, 5th Floor, BOX ACB, 2210-2 St. SW, Calgary, AB T2S 3C3, Canada
  • Alberta Health Services (CA)
  • McMaster University (CA)
  • Hospital for Sick Children (CA)
  • University of Alberta (CA)
Corresponding author
Fidler-Benaoudia, Miranda M.
ORCID
Venue
Cancers
Publisher
MDPI AG
Published
2021-09-28
Volume
13
Issue
19
Pages
4870
ISSN
2072-6694 (ISSN-L)
DOI
10.3390/cancers13194870
PMC
PMC8508204
OpenAlex
W3204670091
Cited by
65
References
142
Citations by year
2026: 15 · 2025: 15 · 2024: 14 · 2023: 14 · 2022: 5 · 2021: 1
FWCI
2.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Cancers (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
  • Health Sciences › Medicine › Epidemiology › Multiple and Secondary Primary Cancers
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
Keywords
adolescent and young adult cancer, cancer survivors, late effects, secondary malignancies, chronic disease, late mortality, risk factors, radiation exposure, socioeconomic status, racial disparities

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