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Cited by 140Pancreatic and Hepatic Oncology ResearchMetabolism, Diabetes, and CancerCancer Risks and Factors

The DOI matches its Crossref record, with a small difference in title or year; 112 of the 113 references it cites were found in a registry or an index.

Diabetes and Pancreatic Cancer: Chicken or Egg?

Magruder, J. Trent, Elahi, Dariush, Andersen, Dana K.·2011·Pancreas
DOI 10.1097/mpa.0b013e318209e05d
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Abstract

OBJECTIVES: Although half of all patients with pancreatic cancer are diabetic at the time of diagnosis, it remains unclear whether the diabetes associated with pancreatic cancer is a cause or an effect of the malignancy. METHODS: Epidemiologic studies were reviewed, the geographic prevalence of diabetes and the incidence of pancreatic cancer were examined, and clinical and laboratory studies were reviewed. RESULTS: Long-standing diabetes increases the risk of pancreatic cancer by 40% to 100%, and recent-onset diabetes is associated with a 4- to 7-fold increase in risk, such that 1% to 2% of patients with recent-onset diabetes will develop pancreatic cancer within 3 years. Treatment of diabetes or morbid obesity decreases the risk of pancreatic cancer, and metformin therapy decreases the risk due to both its antidiabetic and antineoplastic effects. Recent-onset diabetes associated with pancreatic cancer likely represents secondary or type 3 diabetes. The discrimination of type 3 diabetes from the more prevalent type 2 diabetes may identify the high-risk subgroup of diabetic patients in whom potentially curable pancreatic cancer may be found. CONCLUSIONS: Type 2 and type 1 diabetes mellitus increase the risk of pancreatic cancer with a latency period of more than 5 years. Type 3 diabetes mellitus is an effect, and therefore a harbinger, of pancreatic cancer in at least 30% of patients.

Overview

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Crossref · 10.1097/mpa.0b013e318209e05d

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112 of 112 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Magruder, J. T., Elahi, D., & Andersen, D. K.
Affiliations
Johns Hopkins University (US)
Corresponding author
  • Magruder, J. Trent
  • Elahi, Dariush
  • Andersen, Dana K.
ORCID
Venue
Pancreas
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-04
Volume
40
Issue
3
Pages
339-351
ISSN
0885-3177 (ISSN-L)
DOI
10.1097/mpa.0b013e318209e05d
OpenAlex
W2314910395
Cited by
140
References
113
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 13 · 2017: 10 · 2016: 12 · 2015: 11 · 2014: 12 · 2013: 14 · 2012: 20
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Locations
  • Pancreas (publishedVersion)
  • PubMed (publishedVersion)
Funders
Memorial Sloan-Kettering Cancer Center
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords
pancreatic cancer, diabetes mellitus, type 3 diabetes, type 2 diabetes, type 1 diabetes, cancer risk, recent-onset diabetes, metformin, obesity, morbid obesity, diabetes treatment, pancreatic cancer incidence
MeSH terms
Diabetes Mellitus, Diabetes Mellitus, Type 2, Female, Glucose, Humans, Male, Metformin, Pancreatic Neoplasms, Risk Factors, Biomarkers, Tumor, United States, Causality, Case-Control Studies, Diabetes Complications, Islet Amyloid Polypeptide

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