Frequencies and Prognostic Role of KRAS and BRAF Mutations in Patients With Localized Pancreatic and Ampullary Adenocarcinomas
Abstract
OBJECTIVES: The frequencies and prognostic role of KRAS and BRAF mutations in patients operated on for pancreatic ductal adenocarcinomas (PDACs) and ampullary adenocarcinomas (A-ACs) are scantily studied. METHODS: KRAS and BRAF mutations were analyzed in formalin-fixed, paraffin-embedded tumor samples from primarily chemotherapy-naive patients operated on with radical intentions for PDAC (n = 170) and A-AC (n = 107). RESULTS: Eighty percent of PDAC patients had KRAS mutations (codon 12 mutations: 74%) and 67% with A-AC (codon 12 mutations: 54%). BRAF mutations were less common, 16% in PDAC and 12% in A-AC, and no V600E mutations were found. Fourteen percent with PDAC and 7% with A-AC had mutations in both KRAS and BRAF. Multivariate analysis, including KRAS status, stage, and American Society of Anesthesiologists physical status classification system score, demonstrated that KRAS mutations in patients with A-AC were associated with short recurrence-free survival (RFS) (hazard ratio, 2.45; 95% confidence interval, 1.19-5.06; P = 0.015) and overall survival (OS) (1.93, 95% 1.12-3.31; P = 0.018). KRAS mutations in patients with PDAC were not associated with RFS and OS. BRAF mutations were not associated with RFS and OS. CONCLUSIONS: KRAS mutations frequencies were high in PDAC and A-AC. KRAS mutations were associated with poor prognosis in patients with A-AC, but not in patients with PDAC.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
KRAS mutations were present in 80% of PDAC and 67% of ampullary adenocarcinomas.
“In examining localized pancreatic and ampullary adenocarcinomas, it was found that KRAS mutations were present in 80% of PDAC and 67% of ampullary adenocarcinomas.”
From Significance of TP53, CDKN2A, SMAD4 and KRAS in Pancreatic Cancer (2024) · cites this paper as [101]
KRAS mutations served as independent prognostic biomarker for shorter overall survival in chemotherapy-naive patients with ampullary adenocarcinoma.
“Notably, KRAS mutations served as an independent prognostic biomarker for shorter overall survival in chemotherapy-naive patients with ampullary adenocarcinoma [101].”
From Significance of TP53, CDKN2A, SMAD4 and KRAS in Pancreatic Cancer (2024) · cites this paper as [101]
In localized and resectable PDAC, KRAS mutation has been found either negatively associated or not associated with survival.
“For example, in localized and rescetable PDACs, KRAS mutation was found to be either negatively associated with or not associated with survival (59, 60).”
From KRAS mutation in pancreatic cancer (2021) · cites this paper as [60]
Cites
Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20073 · Cited by 12,596 · see citing works
Mutations of the BRAF gene in human cancer
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674 · see citing works
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969 · see citing works
Hidalgo, M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0901557 · Cited by 2,570 · see citing works
RAS oncogenes: the first 30 years
Malumbres, M., & Barbacid, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1097 · Cited by 1,902 · see citing works
Li, D., Xie, K., Wolff, R. A., & Abbruzzese, J. L. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15841-8 · Cited by 1,715 · see citing works
Roth, A. D., Tejpar, S., Delorenzi, M., Yan, P., Fiocca, R., Klingbiel, D., Dietrich, D., Biesmans, B., Bodoky, G., Barone, C., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.3452 · Cited by 1,178 · see citing works
Kindler, H. L., Niedzwiecki, D., Hollis, D. R., Sutherland, S., Schrag, D., Hurwitz, H. I., Innocenti, F., Mulcahy, M. F., O'Reilly, E. M., Wozniak, T. F., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.1386 · Cited by 848 · see citing works
Molecular Mechanisms of Resistance to Cetuximab and Panitumumab in Colorectal Cancer
Bardelli, A., & Siena, S. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.6116 · Cited by 746 · see citing works
Maitra, A., & Hruban, R. H. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.154305 · Cited by 707 · see citing works
Philip, P. A., Benedetti, J., Corless, C. L., Wong, R., O'Reilly, E. M., Flynn, P. J., Rowland, K. M., Atkins, J. N., Mirtsching, B. C., Rivkin, S. E., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.7550 · Cited by 632 · see citing works
Richman, S. D., Seymour, M. T., Chambers, P., Elliott, F., Daly, C. L., Meade, A. M., Taylor, G., Barrett, J. H., & Quirke, P. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.4295 · Cited by 560 · see citing works
Meta-Analyses of Chemotherapy for Locally Advanced and Metastatic Pancreatic Cancer
Sultana, A., Smith, C. T., Cunningham, D., Starling, N., Neoptolemos, J. P., & Ghaneh, P. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.2551 · Cited by 442 · see citing works
Determinants of caregiving experiences and mental health of partners of cancer patients
Nijboer, C., Triemstra, M., Tempelaar, R., Sanderman, R., & van den Bos, G. A. M. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990815)86:4 · Cited by 334 · see citing works
Campbell, P. M., Groehler, A. L., Lee, K. M., Ouellette, M. M., Khazak, V., & Der, C. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3752 · Cited by 215 · see citing works
Pathogenesis of carcinoma of the papilla of Vater
Fischer, H., & Zhou, H. (2004) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s00534-004-0898-3 · Cited by 205 · see citing works
Alcohol Intake and Pancreatic Cancer Risk: A Pooled Analysis of Fourteen Cohort Studies
Genkinger, J. M., Spiegelman, D. L., Anderson, K. E., Bergkvist, L., Bernstein, L., van den Brandt, P. A., English, D. R., Freudenheim, J. L., Fuchs, C. S., Giles, G. G., et al. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0880 · Cited by 202 · see citing works
KRAS Mutation in Stage III Colon Cancer and Clinical Outcome Following Intergroup Trial CALGB 89803
Ogino, S., Meyerhardt, J. A., Irahara, N., Niedzwiecki, D., Hollis, D. R., Saltz, L. B., Mayer, R. J., Schaefer, P., Whittom, R., Hantel, A., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1570 · Cited by 197 · see citing works
Koorstra, J.-B. M., Hustinx, S. R., Offerhaus, G. J. A., & Maitra, A. (2008) · Pancreatology · doi:10.1159/000123838 · Cited by 180 · see citing works
Smith, G. C., Bounds, R., Wolf, H., Steele, R. J., CAREY, F. A., & Wolf, C. R. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605534 · Cited by 176 · see citing works
Genetic Mutations Associated with Cigarette Smoking in Pancreatic Cancer
Blackford, A. L., Parmigiani, G., Kensler, T. W., Wolfgang, C. L., Jones, S., Zhang, X., Parsons, D. W., Lin, J., Leary, R. J., Eshleman, J. R., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0015 · Cited by 134 · see citing works
Kleeff, J. H., Michalski, C. W., Frieß, H., & Büchler, M. W. (2006) · Pancreas · doi:10.1097/01.mpa.0000229010.62538.f2 · Cited by 132 · see citing works
Lee, J., Jang, K., Ki, C., Lim, T., Park, Y. S., Lim, H. Y., Choi, D., Kang, W. K., Park, K., & Park, J. O. (2007) · Cancer · doi:10.1002/cncr.22559 · Cited by 127 · see citing works
Immervoll, H., Hoem, D., Kugarajh, K., Steine, S. J., & Molven, A. (2006) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-006-0191-8 · Cited by 85 · see citing works
Genetic and Epigenetic Alterations of Familial Pancreatic Cancers
Brune, K. A., Hong, S., Li, A., Yachida, S., Abe, T., Griffith, M., Yang, D., Omura, N., Eshleman, J. R., Canto, M. I., et al. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0630 · Cited by 82 · see citing works
Molecular Aspects of Pancreatic Cancer and Future Perspectives
Friess, H., Kleeff, J. H., Korc, M., & Büchler, M. W. (1999) · Digestive Surgery · doi:10.1159/000018737 · Cited by 82 · see citing works
Agoff, S. N., Crispin, D. A., Bronner, M. P., Dail, D. H., Hawes, S. E., & Haggitt, R. C. (2001) · Modern Pathology · doi:10.1038/modpathol.3880270 · Cited by 73 · see citing works
Laghi, L., Orbetegli, O., Bianchi, P. P., Zerbi, A., Carlo, V. D., Boland, C. R., & Malesci, A. (2002) · Oncogene · doi:10.1038/sj.onc.1205533 · Cited by 72 · see citing works
Seth, R., Crook, S., Ibrahem, S., Fadhil, W., Jackson, D., & Ilyas, M. (2009) · Gut · doi:10.1136/gut.2008.159137 · Cited by 66 · see citing works
Feldmann, G., & Maitra, A. (2008) · Journal of Molecular Diagnostics · doi:10.2353/jmoldx.2008.070115 · Cited by 57 · see citing works
Esposito, I., Friess, H., & Büchler, M. W. (2001) · Langenbeck s Archives of Surgery · doi:10.1007/s004230100232 · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer
Buscail, L., Bournet, B., & Cordelier, P. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0245-4 · Cited by 721 · see citing works
KRAS mutation in pancreatic cancer
Luo, J. (2021) · Seminars in Oncology · doi:10.1053/j.seminoncol.2021.02.003 · Cited by 360 · see citing works
Identification of T-cell Receptors Targeting KRAS-Mutated Human Tumors
Wang, Q. J., Yu, Z., Griffith, K., Hanada, K.-I., Restifo, N. P., & Yang, J. C. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0188 · Cited by 240 · see citing works
KRAS G12D Mutation Subtype Is A Prognostic Factor for Advanced Pancreatic Adenocarcinoma
Bournet, B., Muscari, F., Buscail, C., Assenat, E., Barthet, M., Hammel, P., Selves, J., Guimbaud, R., Cordelier, P., & Buscail, L. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.18 · Cited by 205 · see citing works
Adoptive Cell Therapy Targeting Neoantigens: A Frontier for Cancer Research
Wang, Z., & Cao, Y. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00176 · Cited by 181 · see citing works
Targeting KRAS for diagnosis, prognosis, and treatment of pancreatic cancer: Hopes and realities
Bournet, B., Buscail, C., Muscari, F., Cordelier, P., & Buscail, L. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.11.012 · Cited by 164 · see citing works
Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid Cancers
Dillon, M., Lopez, A. R., Lin, E., Sales, D., Perets, R., & Jain, P. (2021) · Cancers · doi:10.3390/cancers13205059 · Cited by 160 · see citing works
Significance of TP53, CDKN2A, SMAD4 and KRAS in Pancreatic Cancer
Stefanoudakis, D., Frountzas, M., Schizas, D., Michalopoulos, N. V., Drakaki, A., & Toutouzas, K. G. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46040177 · Cited by 110 · see citing works
Philip, P. A., Goldman, B. H., Ramanathan, R. K., Lenz, H., Lowy, A. M., Whitehead, R. P., Wakatsuki, T., Iqbal, S., Gaur, R., Benedetti, J., et al. (2014) · Cancer · doi:10.1002/cncr.28744 · Cited by 94 · see citing works
Genomically Driven Tumors and Actionability across Histologies:BRAF-Mutant Cancers as a Paradigm
Turski, M. L., Vidwans, S. J., Jankú, F., Garrido‐Laguna, I., Munoz, J., Schwab, R. B., Subbiah, V., Rodon, J. A., & Kurzrock, R. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0643 · Cited by 91 · see citing works
Schultz, N. A., Andersen, K. K., Roslind, A., Willenbrock, H., Wøjdemann, M., & Johansen, J. S. (2012) · World Journal of Surgery · doi:10.1007/s00268-012-1705-y · Cited by 89 · see citing works
Self-citationGenetic Progression of Pancreatic Cancer
Cowan, R. W., & Maitra, A. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000011 · Cited by 76 · see citing works
Øster, B., Linnet, L., Christensen, L. L., Thorsen, K., Ongen, H., Dermitzakis, E. T., Sandoval, J., Morán, S., Esteller, M., Hansen, T. F., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.27921 · Cited by 73 · see citing works
New Developments in the Molecular Mechanisms of Pancreatic Tumorigenesis
Felsenstein, M., Hruban, R. H., & Wood, L. D. (2017) · Advances in Anatomic Pathology · doi:10.1097/pap.0000000000000172 · Cited by 54 · see citing works
Mafficini, A., Amato, E., Cataldo, I., Rusev, B. C., Bertoncello, L., Corbo, V., Simbolo, M., Luchini, C., Fassan, M., Cantù, C., et al. (2016) · Annals of Surgery · doi:10.1097/sla.0000000000001999 · Cited by 49 · see citing works
Nusrat, F., Khanna, A., Jain, A., Jiang, W., Lavu, H., Yeo, C. J., Bowne, W. B., & Nevler, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13072103 · Cited by 47 · see citing works
Genetic Alterations of Periampullary and Pancreatic Ductal Adenocarcinoma: An Overview
Sikdar, N., Saha, G., Dutta, A., Ghosh, S., Shrikhande, S. V., & Banerjee, S. (2018) · Current Genomics · doi:10.2174/1389202919666180221160753 · Cited by 48 · see citing works
Abnormal distribution of peripheral lymphocyte subsets induced by PDAC modulates overall survival
Xu, Y.-F., Yu, L., He, C., Shi, S., Xu, J., Long, J., Liu, L., Liu, C., & Yu, X. (2014) · Pancreatology · doi:10.1016/j.pan.2014.05.797 · Cited by 46 · see citing works
Prognostic significance of K-ras mutations in pancreatic cancer: a meta-analysis
Tao, L., Zhang, L., Xiu, D., Yuan, C., Ma, Z., & Jiang, B. (2016) · World Journal of Surgical Oncology · doi:10.1186/s12957-016-0888-3 · Cited by 44 · see citing works
Survival in ampullary cancer: Potential role of different KRAS mutations
Valsangkar, N. P., Ingkakul, T., Correa‐Gallego, C., Mino-Kenudson, M. A., Masia, R., Lillemoe, K. D., Castillo, C. F.-D., Warshaw, A. L., Liss, A. S., & Thayer, S. P. (2015) · Surgery · doi:10.1016/j.surg.2014.08.092 · Cited by 43 · see citing works
Allaway, R. J., Fischer, D. A., Abreu, F. B. D., Gardner, T. B., Gordon, S. R., Barth, R. J., Colacchio, T. A., Wood, M. D., Kacsoh, B. Z., Bouley, S. J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7718 · Cited by 41 · see citing works
Krasinskas, A. M., Chiosea, S. I., Pal, T. R., & Đačić, S. (2013) · Modern Pathology · doi:10.1038/modpathol.2013.146 · Cited by 39 · see citing works
Zhou, L., Baba, Y., Kitano, Y., Miyake, K., Zhang, X., Yamamura, K., Kosumi, K., Kaida, T., Arima, K., Taki, K., et al. (2016) · Medical Oncology · doi:10.1007/s12032-016-0745-9 · Cited by 36 · see citing works
Perkins, G., Svrcek, M., Bouchet-Doumenq, C., Voron, T., Colussi, O., Debove, C., Merabtene, F., Dumont, S., Sauvanet, A., Hammel, P. R., et al. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0415-8 · Cited by 34 · see citing works
Tignanelli, C. J. (2020) · PubMed · doi:10.17615/pgs0-9719 · Cited by 34 · see citing works
Mikhitarian, K., Pollen, M., Zhao, Z., Shyr, Y., Merchant, N. B., Parikh, A. A., Revetta, F. L., Washington, M. K., Vnencak‐Jones, C. L., & Shi, C. (2013) · Modern Pathology · doi:10.1038/modpathol.2013.185 · Cited by 33 · see citing works
Li, T., Zheng, Y., Sun, H., Zhuang, R., Liu, J., Liu, T., & Cai, W. (2016) · Medical Oncology · doi:10.1007/s12032-016-0777-1 · Cited by 30 · see citing works
KRAS mutational analysis in ductal adenocarcinoma of the pancreas and its clinical significance
Miglio, U., Oldani, A., Mezzapelle, R., Veggiani, C., Paganotti, A., Garavoglia, M., & Boldorini, R. L. (2014) · Pathology - Research and Practice · doi:10.1016/j.prp.2014.01.011 · Cited by 28 · see citing works
Kwon, M. J., Kim, J. W., Jung, J. P., Cho, J. W., Nam, E. S., Cho, S. J., Kim, J. S., Park, H., Min, S. K., Seo, J., et al. (2015) · Human Pathology · doi:10.1016/j.humpath.2015.11.009 · Cited by 27 · see citing works
Advances in Molecular Pathology and Treatment of Periampullary Cancers
Chandrasegaram, M. D., Chen, J. W., Price, T. J., Zalcberg, J. R., Sjoquist, K. M., & Merrett, N. D. (2015) · Pancreas · doi:10.1097/mpa.0000000000000385 · Cited by 26 · see citing works
Hu, J., Kwak, K. J., Shi, J., Yu, B., Sheng, Y., & Lee, L. J. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.038 · Cited by 26 · see citing works
Primary small bowel adenomas and adenocarcinomas—recent advances
Maguire, A. A., & Sheahan, K. D. (2018) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-018-2400-7 · Cited by 24 · see citing works
Suzuki, T., Masugi, Y., Inoue, Y., Hamada, T., Tanaka, M. H., Takamatsu, M., Arita, J., Kato, T., Kawaguchi, Y., Kunita, A., et al. (2022) · Cancer Science · doi:10.1111/cas.15398 · Cited by 21 · see citing works
Promising new treatments for pancreatic cancer in the era of targeted and immune therapies.
Elaileh, A., Saharia, A., Potter, L. M., Baio, F. E., Ghafel, A. N., Abdelrahim, M., & Heyne, K. (2019) · Europe PMC (PubMed Central) · Cited by 21 · see citing works
Kwon, M. J., Jeon, J. Y., Park, H., Nam, E. S., Cho, S. J., Shin, H. S., Kwon, J. H., Kim, J. S., Han, B., Kim, D. H., et al. (2014) · Pancreas · doi:10.1097/mpa.0000000000000280 · Cited by 21 · see citing works
Egelí, Ü., Tezcan, G., Çeçener, G., Tunca, B., Demirdöğen, E., Kaya, E., Aksoy, S. A., Dündar, H. Z., Sarkut, P., Uğraş, N., et al. (2016) · Pancreas · doi:10.1097/mpa.0000000000000640 · Cited by 20 · see citing works
Intraductal papillary mucinous neoplasms of the pancreas: Clinical association with KRAS
Chang, X., Wu, Y., Li, Y., Wang, J., & Chen, J. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8875 · Cited by 20 · see citing works
Perineural Invasion is a Strong Prognostic Moderator in Ampulla of Vater Carcinoma
Luchini, C., Veronese, N., Nottegar, A., Riva, G., Pilati, C., Mafficini, A., Stubbs, B., Simbolo, M., Mombello, A., Corbo, V., et al. (2018) · Pancreas · doi:10.1097/mpa.0000000000001194 · Cited by 18 · see citing works
KRAS mutation as a prognostic factor in ampullary adenocarcinoma: a meta-analysis and review
Kim, B. J., Jang, H. J., Kim, J. H., Kim, H. S., & Lee, J. (2016) · Oncotarget · doi:10.18632/oncotarget.11156 · Cited by 18 · see citing works
Ampullary carcinoma—A genetic perspective
Jayaramayya, K., Vellingiri, B., & Santhy, K. S. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.03.002 · Cited by 17 · see citing works
Kwon, M. J., Kim, J. W., Jeon, J. Y., Nam, E. S., Cho, S. J., Park, H., Min, S. K., Seo, J., Min, K., Choe, J., et al. (2017) · Pathology - Research and Practice · doi:10.1016/j.prp.2017.01.004 · Cited by 13 · see citing works
Endoscopic papillectomy andKRASexpression in the treatment of adenoma in the major duodenal papilla
Haraldsson, E., Swahn, F., Verbeke, C. S., Mattsson, J. S., Enochsson, L., Ung, K., Lundell, L. R., Heuchel, R. L., Löhr, M. J., & Arnelo, U. (2015) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2015.1046912 · Cited by 12 · see citing works
Liang, H., Zhu, Y. M., & Wu, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1135324 · Cited by 12 · see citing works
Nanotherapeutics promises for colorectal cancer and pancreatic ductal adenocarcinoma
Bhaw‐Luximon, A., Goonoo, N., & Jhurry, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-42863-7.00006-2 · Cited by 12 · see citing works
Molecular pathways in periampullary cancer: An overview
Apurva, A., Sattar, R. S. A., Ali, A., Nimisha, Sharma, A. K., Kumar, A., Santoshi, S., & Saluja, S. S. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110461 · Cited by 11 · see citing works
Lemstrová, R., Brynychová, V., Hughes, D. J., Hlaváč, V., Dvořák, P., Doherty, J., Murray, H. A., Crockard, M. A., Oliverius, M., Hlavsa, J., et al. (2017) · Oncology Letters · doi:10.3892/ol.2017.6946 · Cited by 10 · see citing works
Ampullary and pancreatic adenocarcinoma—a comparative study
Ferchichi, M., Jouini, R., Koubâa, W., Khanchel, F., Helal, I., Haddad, D., Bibani, N., Chadli‐Debbiche, A., & BenBrahim, E. (2019) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo.2018.09.09 · Cited by 9 · see citing works
Lundgren, S., Hau, S. O., Elebro, J., Heby, M., Karnevi, E., Nodin, B., Eberhard, J., Holm, K., Staaf, J., Jönsson, G. B., et al. (2019) · JCO Precision Oncology · doi:10.1200/po.18.00323 · Cited by 9 · see citing works
KRAS, NRAS and BRAF analysis of ampullary adenocarcinoma classified using CK7, CK20, MUC1 and MUC2
Ferchichi, M., Jouini, R., Ayari, I., Koubâa, W., Chadli‐Debbiche, A., & BenBrahim, E. (2018) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo.2018.05.03 · Cited by 9 · see citing works
Can we predict long-term survival in resectable pancreatic ductal adenocarcinoma?
Gall, T., Gerrard, G., Frampton, A. E., Castellano, L., Ahmad, R., Habib, N. A., Spalding, D. R. C., Pai, M., Foroni, L., & Jiao, L. R. (2019) · Oncotarget · doi:10.18632/oncotarget.26511 · Cited by 8 · see citing works
Metabolomic Approach to Identify Potential Biomarkers in KRAS-Mutant Pancreatic Cancer Cells
Kim, B., & Jung, J. (2024) · Biomedicines · doi:10.3390/biomedicines12040865 · Cited by 7 · see citing works
Implications of Antigen Selection on T Cell-Based Immunotherapy
Camp, F. A., & Slansky, J. E. (2021) · Pharmaceuticals · doi:10.3390/ph14100993 · Cited by 7 · see citing works
Preoperative Prognostic Factors in Resectable Pancreatic Cancer: State of the Art and Prospects
Boubaddi, M., Rossi, J., Marichez, A., Marty, M., Amintas, S., Laurent, C., & Dabernat, S. (2025) · Annals of Surgical Oncology · doi:10.1245/s10434-025-17062-w · Cited by 6 · see citing works
KRAS mutation allele frequency threshold alters prognosis in right‐sided resected pancreatic cancer
Nauheim, D. O., Moskal, D., Renslo, B., Chadwick, M., Jiang, W., Yeo, C. J., Nevler, A., Bowne, W. B., & Lavu, H. (2022) · Journal of Surgical Oncology · doi:10.1002/jso.26860 · Cited by 6 · see citing works
Niu, L., Xu, Z., Liu, H., Cao, H., & Yang, G. (2017) · Molecular and Clinical Oncology · doi:10.3892/mco.2017.1216 · Cited by 6 · see citing works
Oncogenesis and the Clinical Significance of K-ras in Pancreatic Adenocarcinoma
Huang, C., Wang, W., Gong, J., & Yang, K. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.5.2699 · Cited by 5 · see citing works
Off-label use of common predictive biomarkers in gastrointestinal malignancies: a critical appraisal
Tessier‐Cloutier, B., Cai, E., & Schaeffer, D. F. (2019) · Diagnostic Pathology · doi:10.1186/s13000-019-0843-z · Cited by 5 · see citing works
Molecular Aberrations in Periampullary Carcinoma
Tewari, M., Swain, J. R., Dixit, V. K., & Shukla, H. S. (2017) · Indian Journal of Surgical Oncology · doi:10.1007/s13193-017-0645-2 · Cited by 4 · see citing works
Hálková, T., Bunganič, B., Traboulsi, E., Minárik, M., Zavoral, M., & Benešová, L. (2024) · Genes · doi:10.3390/genes15101302 · Cited by 4 · see citing works
Chao, T., Wang, Z., Bowne, W. B., Yudkoff, C. J., Torjani, A., Swaminathan, V., Kavanagh, T. R., Roadarmel, A., Sholevar, C. J., Cannaday, S., et al. (2024) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2023-0005-oa · Cited by 4 · see citing works
Gutiérrez, M. L., Muñoz‐Bellvís, L., Sarasquete, M. E., Hernández, D. G., Abad, M., Bengoechea, Ó., Corchete, L. A., González‐González, M., García-García, J., González, M., et al. (2014) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2014.06.007 · Cited by 4 · see citing works
Kappan, M. M., & George, J. (2023) · Journal of Natural Remedies · doi:10.18311/jnr/2023/31947 · Cited by 3 · see citing works
Prophylactic vaccines against cancers of non-infectious origin: a dream or a real possibility?
Vonka, V., & Hirsch, I. (2021) · Central European Journal of Public Health · doi:10.21101/cejph.a7219 · Cited by 2 · see citing works
Tignanelli, C. J., Hererra, S. G., & Yeh, J. J. (2014) · The American Surgeon · doi:10.1177/000313481408000920 · Cited by 1 · see citing works
Pancreatic tumors: an overview
Tirado, C. A., Shabsovich, D., Ji, J., & Dawson, D. W. (2014) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/53088 · Cited by 1 · see citing works
Effect of Subtype of K-Ras Mutation on Survival in Resected Pancreatic Adenocarcinoma
Chu, K., & Sherman, W. H. (2015) · JOP, journal of the pancreas · Cited by 1 · see citing works
De Michele, F., Pinto, F. D., Fucilli, F., Ignazzi, A., Valentini, A. M., & Ml, C. (2019) · Journal of Translational Science · doi:10.15761/jts.1000297
Investigating post-translational modifications of B-Raf in cancer
Williams, J. A. (2024) · Queensland University of Technology · doi:10.5204/thesis.eprints.250811
- Authors
- Schultz, N. A., Roslind, A., Christensen, I. J., Horn, T., Høgdall, E., Pedersen, L. N., Kruhøffer, M., Burcharth, F., Wøjdemann, M., & Johansen, J. S.
- Affiliations
- Herlev Hospital (DK)
- University of Copenhagen (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Corresponding author
- Schultz, Nicolai Aagaard
- Burcharth, Flemming
- Wøjdemann, Morten
- Johansen, Julia S.
- Venue
- Pancreas
- Published
- 2012-07
- Volume
- 41
- Issue
- 5
- Pages
- 759-766
- ISSN
- 0885-3177 (ISSN-L)
- OpenAlex
- W2006022749
- Cited by
- 68
- References
- 31
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 11 · 2015: 6 · 2014: 8 · 2013: 3 · 2012: 2
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pancreas (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Aarhus Universitetshospital
- Gentofte Hospital
- Herlev Hospital
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- KRAS mutation, BRAF mutation, pancreatic ductal adenocarcinoma, ampullary adenocarcinoma, KRAS codon 12, prognostic factors, recurrence-free survival, overall survival
- MeSH terms
- Adenocarcinoma, Adult, Aged, Aged, 80 and over, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Mutation, Neoplasm Staging, Pancreatic Neoplasms, Prognosis, Proto-Oncogene Proteins, Smoking, Ampulla of Vater, Multivariate Analysis, Proto-Oncogene Proteins p21(ras), ras Proteins, Carcinoma, Pancreatic Ductal, Proto-Oncogene Proteins B-raf, Kaplan-Meier Estimate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
