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Cited by 235Inflammatory Bowel DiseaseClinical Nutrition and GastroenterologyGut microbiota and health

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Clinical and Mucosal Improvement With Specific Carbohydrate Diet in Pediatric Crohn Disease

Cohen, Stanley A., Gold, Benjamin D., Oliva, Salvatore, Lewis, Jeffery, Stallworth, Angela, Koch, Bailey, Eshee, Laura, Mason, David·2014·Journal of Pediatric Gastroenterology and Nutrition
DOI 10.1097/mpg.0000000000000449
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Abstract

Objective: The aim of the study was to prospectively evaluate clinical and mucosal responses to the specific carbohydrate diet (SCD) in children with Crohn disease (CD). Methods: Eligible patients with active CD (Pediatric Crohn's Disease Activity Index [PCDAI] ≥ 15) underwent a patency capsule and, if passed intact, capsule endoscopy (CE) was performed. Patients taking SCD were monitored for 52 weeks while maintaining all prescribed medications. Demographic, dietary, and clinical information, PCDAI, Harvey‐Bradshaw Index (HBI), and Lewis score (LS) were collected at 0, 12, and 52 weeks. CEs were evaluated by an experienced reader blinded to patient clinical information and timing. Results: Sixteen patients were screened; 10 enrolled; and 9 completed the initial 12‐week trial—receiving 85% of estimated caloric needs before, and 101% on the SCD. HB significantly decreased from 3.3 ± 2.0 to 0.6 ± 1.3 ( P = 0.007) as did PCDAI (21.1 ± 5.9 to 7.8 ± 7.1, P = 0.011). LS declined significantly from 2153 ± 732 to 960 ± 433 ( P = 0.012). Seven patients continued the SCD up to 52 weeks; HB (0.1 ± 0.4) and PCDAI (5.4 ± 5.5) remained improved ( P = 0.016 and 0.027 compared to baseline), with mean LS at 1046 ± 372 and 2 patients showed sustained mucosal healing. Conclusions: Clinical and mucosal improvements were seen in children with CD, who used SCD for 12 and 52 weeks. In addition, CE can monitor mucosal improvement in treatment trials for pediatric CD. Further studies are critically needed to understand the mechanisms underlying SCD's effectiveness in children with CD.

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Crossref · 10.1097/mpg.0000000000000449

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Research works printed but not linked: 2

  1. 10.1002/j.1536-4801.2000.tb02821.x · DOI
  2. Gottschall E, 1987, Breaking the Vicious Cycle: Intestinal Health Through Diet

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Metadata

Authors
Cohen, S. A., Gold, B. D., Oliva, S., Lewis, J., Stallworth, A., Koch, B., Eshee, L., & Mason, D.
Affiliations
  • Children's Center for Digestive Health Care Atlanta GA
  • Sapienza University of Rome (IT)
  • Children's Healthcare of Atlanta (US)
  • Given Imaging Yoqneam Israel
Corresponding author
  • Cohen, Stanley A.
  • Gold, Benjamin D.
  • Lewis, Jeffery
  • Stallworth, Angela
  • Koch, Bailey
ORCID
Venue
Journal of Pediatric Gastroenterology and Nutrition
Publisher
Wiley
Published
2014-10
Volume
59
Issue
4
Pages
516-521
ISSN
  • 0277-2116 (ISSN-L)
  • 1536-4801
DOI
10.1097/mpg.0000000000000449
OpenAlex
W2123343371
Cited by
235
References
26
Citations by year
2026: 10 · 2025: 16 · 2024: 16 · 2023: 17 · 2022: 27 · 2021: 23 · 2020: 24 · 2019: 27 · 2018: 14 · 2017: 24 · 2016: 15 · 2015: 17 · 2014: 3
FWCI
12.92
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Pediatric Gastroenterology and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
specific carbohydrate diet, pediatric Crohn's disease, mucosal healing, capsule endoscopy, Harvey-Bradshaw Index, Lewis score, Pediatric Crohn's Disease Activity Index, dietary therapy, treatment response
MeSH terms
Adolescent, Energy Intake, Child, Crohn Disease, Dietary Carbohydrates, Female, Humans, Intestinal Mucosa, Male, Prospective Studies, Capsule Endoscopy

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