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Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants: A Randomized, Double‐blind, Multicenter Study
Open accessAbstract
We determined the effect of short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V on the gut microbiota of cesarean-born infants. Infants were randomized to receive a standard formula (control), the same with scGOS/lcFOS and B. breve M-16V (synbiotic), or with scGOS/lcFOS (prebiotic) from birth until week 16, 30 subjects born vaginally were included as a reference group. Synbiotic supplementation resulted in a higher bifidobacteria proportion from day 3/5 (P < 0.0001) until week 8 (P = 0.041), a reduction of Enterobacteriaceae from day 3/5 (P = 0.002) till week 12 (P = 0.016) compared to controls. This was accompanied with a lower fecal pH and higher acetate. In the synbiotic group, B. breve M-16V was detected 6 weeks postintervention in 38.7% of the infants. This synbiotic concept supported the early modulation of Bifidobacterium in C-section born infants that was associated with the emulation of the gut physiological environment observed in vaginally delivered infants.
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“supplementation with probiotics and prebiotics can be used to decrease the impact of delivery mode on the microbiota (Chua et al., 2017;Moya-Perez et al., 2017a).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Chua et al., 2017
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Metadata
- Authors
- Chua, M. C., Ben‐Amor, K., Lay, C., Goh, A. E. N., Chiang, W. C., Rao, R., Chew, C., Chaithongwongwatthana, S., Khemapech, N., Knol, J., & Chongsrisawat, V.
- Affiliations
- KK Women's and Children's Hospital (SG)
- Danone Nutricia Research Utrecht The Netherlands
- Danone Nutricia Research Singapore
- Chulalongkorn University (TH)
- Nutricia Research (Netherlands) (NL)
- Corresponding author
- Chua, Mei Chien
- Goh, Anne E.N.
- Chiang, Wen Chin
- Rao, Rajeshwar
- ORCID
- Venue
- Journal of Pediatric Gastroenterology and Nutrition
- Publisher
- Wiley
- Published
- 2017-07
- Volume
- 65
- Issue
- 1
- Pages
- 102-106
- ISSN
- 0277-2116 (ISSN-L)
- 1536-4801
- OpenAlex
- W2611643124
- Cited by
- 117
- References
- 20
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 20 · 2023: 12 · 2022: 11 · 2021: 20 · 2020: 13 · 2019: 7 · 2018: 10 · 2017: 1
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Pediatric Gastroenterology and Nutrition (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Funders
- American Friends of Laniado Hospital
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- synbiotics, gut microbiota, cesarean section, infants, Bifidobacterium breve M-16V, prebiotics, Bifidobacterium, Enterobacteriaceae, fecal pH, acetate, infant formula supplementation
- MeSH terms
- Gastrointestinal Microbiome, Bifidobacterium breve, Cesarean Section, Double-Blind Method, Female, Humans, Infant, Infant, Newborn, Male, Oligosaccharides, Pregnancy, Outcome Assessment, Health Care, Infant Formula, Synbiotics
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