The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Celiac Disease Symptom Resolution: Effectiveness of the Gluten‐free Diet
Abstract
Objective The aim of the study was to evaluate the efficacy of the gluten-free diet (GFD) on gastrointestinal (GI) and extra-intestinal (EI) symptom resolution and identify predictors for persistence of symptoms in all celiac patients at the University of Chicago. Methods We conducted a retrospective chart review from 2002 to 2015. GI symptoms included abdominal pain, bloating, constipation, diarrhea, failure to thrive/weight loss, nausea, reflux, and vomiting. EI symptoms included abnormal liver enzymes, arthralgia/arthritis, dermatitis herpetiformis, alopecia, fatigue, headache, anemia, stomatitis, myalgia, psychiatric disorders, rashes, seizures, neuropathy, short stature, delayed puberty, osteoporosis, and infertility. Results A total of 554 patients (227 children) with celiac disease (CeD) were included. Abdominal pain, diarrhea and failure to thrive were the most common GI symptoms in children whereas diarrhea, bloating, and abdominal pain were most common in adults. Short stature, fatigue, and headache were the most common EI symptoms in children whereas iron deficiency anemia, fatigue, and headache/psychiatric disorders were most common in adults. Children had significantly higher rates of EI and GI symptom resolution as compared to adults, with greater rates of improvements in GI versus EI symptoms at more than 24 months. Long duration of symptoms, female sex, and non-adherence to a GFD were the most important significant predictors of failure to clinically improve.…
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“Paediatric patients on a strict GFD usually show rapid resolution of CD-related gastrointestinal symptoms, such as bloating, diarrhoea, abdominal pain, weight loss, as well as of extra-intestinal manifestations such as anaemia, delayed puberty and stomatitis (20).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [20]
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A Review on the Gluten-Free Diet: Technological and Nutritional Challenges
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Extraintestinal Manifestations of Celiac Disease: Early Detection for Better Long-Term Outcomes
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Metadata
- Authors
- Sansotta, N., Amirikian, K., Guandalini, S., & Jericho, H.
- Affiliations
- University of Verona (IT)
- University of Chicago (US)
- Corresponding author
- Sansotta, Naire
- Venue
- Journal of Pediatric Gastroenterology and Nutrition
- Publisher
- Wiley
- Published
- 2018-01
- Volume
- 66
- Issue
- 1
- Pages
- 48-52
- ISSN
- 0277-2116 (ISSN-L)
- 1536-4801
- OpenAlex
- W2614531184
- Cited by
- 109
- References
- 21
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 19 · 2023: 14 · 2022: 12 · 2021: 9 · 2020: 13 · 2019: 12 · 2018: 8
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Gastroenterology and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Gastroenterology › Eosinophilic Esophagitis
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- celiac disease, gluten-free diet, symptom resolution, gastrointestinal symptoms, extraintestinal manifestations, pediatric celiac disease, adult celiac disease, dietary adherence, iron deficiency anemia, short stature, failure to thrive, abdominal pain
- MeSH terms
- Adolescent, Celiac Disease, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Male, Patient Compliance, Retrospective Studies, Treatment Outcome, Diet, Gluten-Free
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