The DOI matches its Crossref record.
Prevalence of Celiac Disease in a Long‐term Study of a Spanish At‐genetic‐risk Cohort From the General Population
Abstract
Objectives: To perform long‐term celiac disease (CD) screening in an HLA‐DQ2 (+) cohort from the general population and to assess the influence of risk genotypes on its development. Methods: In 2004, an HLA‐DQ2 (+) cohort was selected. After the first CD screening at age 2 to 3 years, we performed a follow‐up screening 8 to 10 years later. Antitransglutaminase 2 antibodies were determined using a rapid test kit. Results were confirmed by serum IgA antitransglutaminase 2 and IgA endomysial antibody determination. CD diagnosis was carried out by intestinal biopsies. Four HLA‐DQ2 genotypic groups were used: G1: DQ2.5/DQ2.5 (G1A) or DQ2.5/ DQ2.2 (G1B); G2: DQ2.2/DQ7.5 (DQ2.5 trans); G3: DQ2.5/ X; G4: DQ2.2/X. Results: CD prevalence after 10 years of follow‐up was 5.8% (95% confidence interval 3.8–8.7). One of every 3 HLA‐DQ2(+) children carried at least 1 haplotype DQ2.2 or DQ7. The homozygous genotype DQ2.5/DQ2.5 and the HLA‐DQ2.5 trans genotype increased CD risk 4‐ and 3‐fold, respectively. The homozygous genotype DQ2.5/ DQ2.2 did not increase the CD risk. Children carrying G1 or G2 genotypes were diagnosed with CD earlier and more frequently during the follow‐up compare with those carrying G3 or G4 genotypes. Approximately 81% of children with spontaneous antibody negativization after the first screening maintained negative antibodies. Conclusions: A repeated screening of at‐risk children during their follow‐up allowed us to diagnose new CD cases. In our cohort, HLA‐ DQ2.5 trans genotype conferred a higher risk in the development of CD than HLA‐ DQ2.5/DQ2.2. The majority of children with potential CD and CD autoimmunity at 10 years of age remained healthy.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The majority remain as 'potential CD,' with a significant percentage of those normalizing their CD antibodies , which is frequently observed in younger children.”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [139]
In the citing paper
“The first two issues find some evidence in the literature (133-140).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [139]
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 29
- 10.1097/MPG.0b013e31821a23d0 · DOI · Paper page
- 10.1038/ajg.2008.8 · DOI
- 10.1056/NEJMoa1404172 · DOI
- 10.1056/NEJMoa1400697 · DOI
- 10.1542/peds.2014-1787 · DOI
- 10.1016/j.jaut.2015.07.003 · DOI
- 10.1073/pnas.2135229100 · DOI
- 10.1016/0198-8859(94)90059-0 · DOI
- 10.1034/j.1399-0039.2002.600205.x · DOI
- 10.3109/07853890.2010.505931 · DOI
- 10.1067/S0022-3476(03)00282-8 · DOI
- 10.1080/00365520510024034 · DOI
- 10.1056/NEJMoa1313977 · DOI
- 10.1097/MPG.0000000000001007 · DOI
- 10.1111/j.0001-2815.2004.00237.x · DOI
- 10.1136/gut.2006.108530 · DOI
- 10.1097/MPG.0b013e31814794b9 · DOI
- 10.1097/MPG.0000000000000946 · DOI
- Liu E, 2017, High incidence of celiac disease in a long‐term study of adolescents with susceptibility genotypes, Gastroenterology, 15, 1329.e1
- 10.1038/ajg.2014.77 · DOI · Paper page
- 10.1111/j.1572-0241.2007.01360.x · DOI
- 10.1097/MPG.0b013e3181615ca7 · DOI
- 10.1016/0198-8859(94)90015-9 · DOI
- 10.1002/(SICI)1098-2272(1997)14:4<413::AID-GEPI6>3.0.CO;2-3 · DOI
- 10.1111/apa.12605 · DOI
- 10.1002/j.1536-4801.2002.tb07685.x · DOI
- 10.1371/journal.pone.0138324 · DOI
- 10.1016/j.humimm.2008.10.018 · DOI
- 10.1097/MPG.0000000000000446 · DOI
Cited by
Sorted by citations
ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease.
Mearin, M. L., Agardh, D., Antunes, H., Al‐toma, A., Auricchio, R., Castillejo, G., Catassi, C., Ciacci, C., Discepolo, V., Dolinsek, J., et al. (2022) · Journal of pediatric gastroenterology and nutrition · doi:10.1097/mpg.0000000000003540 · Cited by 186
Metadata
- Authors
- Fernández‐Fernández, S., Borrell, B., Cilleruelo, M. L., Tabares, A., Jiménez‐Jiménez, J., Rayo, A. I., Perucho, T., & García‐García, M. L.
- Affiliations
- Universidad Alfonso X el Sabio (ES)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Pediatric Gastroentetology Unit Department of Pediatrics San Rafael Hospital Madrid Spain
- Hospital Universitario Severo Ochoa (ES)
- Molecular Genetist Genyca Genetics Madrid Spain
- Department of Pediatrics Severo Ochoa University Hospital Alfonso X el Sabio University Madrid Spain
- Corresponding author
- Fernández‐Fernández, Sonia
- Borrell, Belén
- Rayo, Ana I.
- Venue
- Journal of Pediatric Gastroenterology and Nutrition
- Publisher
- Wiley
- Published
- 2019-03
- Volume
- 68
- Issue
- 3
- Pages
- 364-370
- ISSN
- 0277-2116 (ISSN-L)
- 1536-4801
- OpenAlex
- W2899660060
- Cited by
- 8
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Gastroenterology and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
- Health Sciences › Medicine › Gastroenterology › Eosinophilic Esophagitis
- Keywords
- celiac disease, prevalence, HLA-DQ2, HLA-DQ2.5, HLA-DQ2.2, HLA-DQ7, genetic risk, vulnerable children, anti-endomysial antibodies, celiac disease screening
- MeSH terms
- Celiac Disease, Child, Child, Preschool, Female, Follow-Up Studies, Genetic Testing, Genotype, Haplotypes, HLA-DQ Antigens, Humans, Longitudinal Studies, Male, Prospective Studies, Risk Factors, Spain, Prevalence, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Prevalence of Celiac Disease in a Long‐term Study of a Spanish At‐genetic‐risk Cohort From the General Population. https://app.cochat.ai/papers/10.1097/mpg.0000000000002195
- The paper
- Fernández‐Fernández, S., Borrell, B., Cilleruelo, M. L., Tabares, A., Jiménez‐Jiménez, J., Rayo, A. I., Perucho, T., & García‐García, M. L. (2019). Prevalence of Celiac Disease in a Long‐term Study of a Spanish At‐genetic‐risk Cohort From the General Population. Journal of Pediatric Gastroenterology and Nutrition. https://doi.org/10.1097/mpg.0000000000002195
