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Cited by 21Celiac Disease Research and ManagementEosinophilic EsophagitisImmunodeficiency and Autoimmune Disorders

Influence of the 2012 European Guidelines in Diagnosis and Follow‐up of Coeliac Children With Selective IgA Deficiency

López, Raquel Vecino, Cid, Carmen Miranda, García, Gloria Rodrigo, Romero, Ruth García, Cilleruelo, Maria Luz, Riechmann, Enriqueta Román, Spanish Working Group on Coeliac Disease (Spanish Society of Paediatric Gastroenterology, Hepatology, Nutrition, SEGHNP)·2020·Journal of Pediatric Gastroenterology and Nutrition
DOI 10.1097/mpg.0000000000002634
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Abstract

Objectives The aim of the study was to describe diagnostic criteria used in children with coeliac disease (CD) and selective IgA deficiency; to determine if the publication of the 2012 ESPGHAN criteria prompted any changes; to evaluate the evolution of serological markers. Methods Multicenter, retrospective, descriptive study of a cohort of children under 15 years with selective IgA deficiency diagnosed with CD (January 2006 to December 2016). Demographic, clinical, genetic, histological and IgG-based antibodies were collected at diagnosis and follow-up. Results Eighty-six children were included, 60 diagnosed after the guide. Two groups were established: G1 (n = 63) and G2 (n = 23) with or without diagnostic biopsy respectively. In G1: 87.3% were symptomatic, 87.3% had human leukocyte antigan (HLA) DQ2/DQ8 typing (all positive), all had IgG serology positive (71.5% ATG, 35% EMA, 19% DPG, 9.5% AGA), and all had villous atrophy (Marsh-Oberhuber 2-3). Follow-up data were available in 58 children, 34 after 2 years on a gluten-free diet. Fifty-two percentage remained ATG IgG-positive despite good dietary adherence and symptom remission. Regarding G2: all were diagnosed post-2012, had typical symptoms, HLA DQ2/DQ8 positive and ATG IgG × 10 ULN. Additionally, EMA IgG was performed in 14 (60%), all positive. Conclusions In our cohort of children with selective IgA deficiency and diagnosed with CD, children without a diagnostic biopsy suggests that IgG serology was considered the equi…

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  • Studies show prolonged recovery time of serological and mucosal changes after introduction of a GFD during follow-up, with half of IgA deficient CD patients having elevated serum IgG specific CD antibodies after two years on a GFD.

    “Studies show prolonged recovery time of serological and mucosal changes after the introduction of GFD during follow-up, with half of IgA deficient CD patients having elevated serum IgG specific CD antibodies after two years on a GFD (132).”

    From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [132]

  • Data from the literature on patients with selective IgA deficiency indicate a longer recovery time for serum IgG CD antibodies after starting a GFD.

    “Data from the literature on patients with selective IgA deficiency indicate a longer recovery time for serum IgG CD antibodies after starting a GFD.”

    From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [132]

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Authors
López, R. V., Cid, C. M., García, G. R., Romero, R. G., Cilleruelo, M. L., Riechmann, E. R., & Spanish Working Group on Coeliac Disease (Spanish Society of Paediatric Gastroenterology, H.
Affiliations
  • Hospital Clínico San Carlos (ES)
  • Hospital General Universitario Gregorio Marañón (ES)
  • Hospital Universitario Infanta Cristina (ES)
  • Hospital Universitario Miguel Servet (ES)
  • Section of Pediatric Gastroenterology Hospital Universitario Puerta de Hierro Madrid Spain
  • Hospital Universitario Puerta de Hierro Majadahonda (ES)
Corresponding author
López, Raquel Vecino
ORCID
García, Gloria Rodrigo
Venue
Journal of Pediatric Gastroenterology and Nutrition
Publisher
Wiley
Published
2020-02-07
Volume
71
Issue
1
Pages
59-63
ISSN
  • 0277-2116 (ISSN-L)
  • 1536-4801
DOI
10.1097/mpg.0000000000002634
OpenAlex
W3006399259
Cited by
21
References
15
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 2
FWCI
2.82
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Pediatric Gastroenterology and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Health Sciences › Medicine › Surgery › Eosinophilic Esophagitis
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords
celiac disease, selective IgA deficiency, children, IgG serology, anti-tissue transglutaminase antibodies, anti-gliadin antibodies, villous atrophy, HLA-DQ2/DQ8, gluten-free diet, serological remission, biopsy diagnosis
MeSH terms
Autoantibodies, Biopsy, Celiac Disease, Child, Follow-Up Studies, Humans, Immunoglobulin A, Transglutaminases, Retrospective Studies, IgA Deficiency

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