The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Progressive Neurodegeneration After Experimental Brain Trauma: Association With Chronic Microglial Activation
Open accessAbstract
Recent clinical studies indicate that traumatic brain injury (TBI) produces chronic and progressive neurodegenerative changes leading to late neurologic dysfunction, but little is known about the mechanisms underlying such changes. Microglial-mediated neuroinflammationis an important secondary injury mechanism after TBI. In human studies, microglial activation has been found to persist for many years after the initial brain trauma, particularly after moderate to severe TBI. In the present study, adult C57Bl/6 mice were subjected to single moderate-level controlled cortical impact and were followed up by longitudinal T2-weighted magnetic resonance imaging in combination with stereologic histologic assessment of lesion volume expansion, neuronal loss, and microglial activation for up to 1 year after TBI. Persistent microglial activation was observed in the injured cortex through 1 year after injury and was associated with progressive lesion expansion, hippocampal neurodegeneration, and loss of myelin. Notably, highly activated microglia that expressed major histocompatibility complex class II (CR3/43), CD68, and NADPH oxidase (NOX2) were detected at the margins of the expanding lesion at 1 year after injury; biochemical markers of neuroinflammation and oxidative stress were significantly elevated at this time point. These data support emerging clinical TBI findings and provide a mechanistic link between TBI-induced chronic microglial activation and progressive neurodegeneration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the minutes following TBI, microglia are recruited via purinergic signaling to clear necrotic debris and adopt a phagocytic state [100,107,108].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [100]
In the citing paper
“TBI is a biphasic injury: after the mechanical primary injury, a secondary dystrophic state produces long-term dysfunction in the brain that includes elevated neuroinflammation as a result of blood-brain barrier disruption, increased oxidative stress, and persistent changes in the microglial population [100–106].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [100]
In the citing paper
“Of recent interest is how post-injury microglia promote increased oxidative damage leading to neurodegeneration through a NOX2-dependent mechanism [100,117,118].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [100]
In the citing paper
“Microglia associated with the long-term inflammatory phenotype following TBI are commonly defined as MHC-II/CD86/Cd11b positive, with upregulated expression of NOX24, Tlr4, Trem2, CD68, Clec7a, and Stat1, and higher expression of interferon- and immune-associated signaling genes [100,112,115,116].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [100]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Kigerl, K. A., Gensel, J. C., Ankeny, D. P., Alexander, J. K., Donnelly, D. J., & Popovich, P. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3257-09.2009 · Cited by 2,130
Hu, X., Li, P., Guo, Y., Wang, H., Leak, R. K., Chen, S., Gao, Y., & Chen, J. (2012) · Stroke · doi:10.1161/strokeaha.112.659656 · Cited by 1,573
Microglia in neurodegenerative disease
Perry, V. H., Nicoll, J. A. R., & Holmes, C. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.17 · Cited by 1,543
The P2Y12 receptor regulates microglial activation by extracellular nucleotides
Haynes, S. E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M. E., Gan, W.-B., & Julius, D. (2006) · Nature Neuroscience · doi:10.1038/nn1805 · Cited by 1,542
Microglial Activation and Chronic Neurodegeneration
Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047 · cited 2×
“In this study, we show that NADPH oxidase is chronically expressed in highly activated microglia surrounding the lesion site at 1 year after injury, and that its activity may be a key driver of self-propagating cycles of microglial-mediated neurodegeneration, as in other models of chronic neurodegenerative diseases (3…”
BackgroundInflammation and white matter degeneration persist for years after a single traumatic brain injury
Johnson, V. E., Stewart, J. E., Begbie, F. D., Trojanowski, J. Q., Smith, D. H., & Stewart, W. (2013) · Brain · doi:10.1093/brain/aws322 · Cited by 1,045
Inflammation after trauma: Microglial activation and traumatic brain injury
Ramlackhansingh, A. F., Brooks, D. J., Greenwood, R. J., Bose, S. K., Turkheimer, F. E., Kinnunen, K. M., Gentleman, S., Heckemann, R. A., Gunanayagam, K., Gelosa, G., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22455 · Cited by 999
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain
Colton, C. A. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9164-4 · Cited by 916
Cited by
Sorted by citations
Items 201–300 of 500
Wang, J., Lu, Y., Carr, C., Dhandapani, K. M., & Brann, D. W. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1227705 · Cited by 35
Giarratana, A. O., Zheng, C., Reddi, S., Teng, S. L., Berger, D. S., Adler, D., Sullivan, P. M., Thakker‐Varia, S., & Alder, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-76849-x · Cited by 39
Aquaporin 4 in Traumatic Brain Injury: From Molecular Pathways to Therapeutic Target
Dadgostar, E., Rahimi, S., Nikmanzar, S., Nazemi, S., Taheri, M. N., Alibolandi, Z., Aschner, M., Mirzaei, H., & Tamtaji, O. R. (2022) · Neurochemical Research · doi:10.1007/s11064-021-03512-w · Cited by 33
Tapias, V., Moschonas, E. H., Bondi, C. O., Vozzella, V. J., Cooper, I. N., B, J. P. C. A., Lajud, N., & Kline, A. E. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114204 · Cited by 33
Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury
Boland, R., & Kokiko‐Cochran, O. N. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1352790 · Cited by 32
Henry, R. J., Barrett, J. P., Vaida, M. L., Khan, N., Makarevich, O. D., Ritzel, R. M., Faden, A. I., & Stoica, B. A. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03107-6 · Cited by 35
Self-citationBhandare, A., Kapoor, K., Powell, K. L., Braine, E. L., Casillas-Espinosa, P. M., O'Brien, T. J., Farnham, M. M. J., & Pilowsky, P. M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.03.012 · Cited by 32
Mild-to-severe traumatic brain injury in children: altered cytokines reflect severity
Ryan, E., Kelly, L. A., Stacey, C., Huggard, D., Duff, E., McCollum, D., Leonard, A., Boran, G. P., Doherty, D. R., Bolger, T., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02390-5 · Cited by 32
Semple, B. D. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.07.013 · Cited by 31
Ferguson, S., Mouzon, B., Paris, D., Aponte, D. A., Abdullah, L. I., Stewart, W. B., Jr., MULLAN, M. J., & Crawford, F. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4636 · Cited by 31
Grovola, M. R., von Reyn, C. R., Loane, D. J., & Cullen, D. K. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02730-z · Cited by 35
Self-citationLiu, J., Zhou, L., Wang, Y.-Z., Wang, X., Zhou, Y., Ho, W., & Li, J. (2016) · Journal of Immunology Research · doi:10.1155/2016/4962351 · Cited by 30
Zhang, Z., Ishrat, S., O'Bryan, M., Klein, B., Saraswati, M., Robertson, C., & Kannan, S. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2019.6894 · Cited by 31
Will Sirtuins Be Promising Therapeutic Targets for TBI and Associated Neurodegenerative Diseases?
Yang, Q., Zhou, Y., Sun, Y., Luo, Y., Shen, Y., & Shao, A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00791 · Cited by 29
Astrocyte-targeted Overproduction of IL-10 Reduces Neurodegeneration after TBI
Bavarsad, M. S., Almolda, B., González, B., & Castellano, B. (2022) · Experimental Neurobiology · doi:10.5607/en21035 · Cited by 30
[ 18 F]FDG-PET Combined with MRI Elucidates the Pathophysiology of Traumatic Brain Injury in Rats
Brabazon, F., Wilson, C. M., Shukla, D. K., Mathur, S., Jaiswal, S., Bermudez, S., Byrnes, K. R., & Selwyn, R. G. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4540 · Cited by 30
Rodriguez‐Grande, B., Ichkova, A., Lemarchant, S., & Badaut, J. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0123-3 · Cited by 29
Arulsamy, A., Teng, J., Colton, H., Corrigan, F., & Collins‐Praino, L. E. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.04.009 · Cited by 28
Drosophila as a model to explore secondary injury cascades after traumatic brain injury
Buhlman, L. M., Krishna, G., Jones, T. B., & Thomas, T. C. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112079 · Cited by 29
Mohamed, A. Z., Cumming, P. D., & Nasrallah, F. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-00660-5 · Cited by 28
Concise Review: Cell Therapies for Stroke and Traumatic Brain Injury: Targeting Microglia
Savitz, S. I., & Cox, C. S. (2016) · Stem Cells · doi:10.1002/stem.2253 · Cited by 29
Repeated mild traumatic brain injury in female rats increases lipid peroxidation in neurons
Yates, N. J., Lydiard, S., Fehily, B., Weir, G., Chin, A., Bartlett, C. A., Alderson, J. A., & Fitzgerald, M. (2017) · Experimental Brain Research · doi:10.1007/s00221-017-4958-8 · Cited by 29
Nasser, M., Ballout, N., Mantash, S., Bejjani, F., Najdi, F., Ramadan, N., Soueid, J., Zibara, K., & Kobeissy, F. H. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00895 · Cited by 30
Giarratana, A. O., Teng, S. L., Reddi, S., Zheng, C., Adler, D., Thakker‐Varia, S., & Alder, J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01175 · Cited by 29
Autologous bone marrow mononuclear cells to treat severe traumatic brain injury in children
Cox, C. S., Notrica, D. M., Juranek, J. J., Miller, J. H., Triolo, F., Kosmach, S. C., Savitz, S. I., Adelson, P. D., Pedroza, C., Olson, S. D., et al. (2024) · Brain · doi:10.1093/brain/awae005 · Cited by 30
Self-citationSchwerin, S. C., Chatterjee, M., Imam-Fulani, A. O., Radomski, K. L., Hutchinson, E. B., Pierpaoli, C. M., & Juliano, S. L. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24218 · Cited by 28
Imaging biomarkers of epileptogenecity after traumatic brain injury – Preclinical frontiers
Immonen, R. J., Harris, N. G., Wright, D. K., Johnston, L. A., Manninen, E., Smith, G. S., Paydar, A., Branch, C. A., & Gröhn, O. H. J. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.10.008 · Cited by 28
Chanmanee, T., Wongpun, J., Tocharus, C., Govitrapong, P., & Tocharus, J. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109703 · Cited by 28
Traumatic brain injury in Brazil: an epidemiological study and systematic review of the literature
MAGALHÃES, A. L. G., de BARROS, J. L. V. M., Cardoso, M. G. D. F., ROCHA, N. P., FALEIRO, R. M., de Souza, L. C., de MIRANDA, A. S., & Teixeira, A. L. (2022) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x-anp-2021-0035 · Cited by 28
Zhang, W., Liu, K., Li, B., Bai, Y., Wang, T., Fu, K., & Sun, G. (2015) · Central European Journal of Immunology · doi:10.5114/ceji.2015.50831 · Cited by 28
Chronic Traumatic Encephalopathy in Athletes Involved with High-impact Sports.
Safinia, C., Bershad, E. M., Clark, H. B., SantaCruz, K. S., Alakbarova, N., Suárez, J. I., & Divani, A. A. (2016) · Journal of vascular and interventional neurology · Cited by 29
Packer, J. M., Giammo, S. G., Wangler, L. M., Davis, A. C., Bray, C. E., & Godbout, J. P. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03451-1 · Cited by 31
Christensen, J., Eyolfson, E., Salberg, S., & Mychasiuk, R. (2020) · Developmental Review · doi:10.1016/j.dr.2020.100943 · Cited by 28
NK1 antagonists attenuate tau phosphorylation after blast and repeated concussive injury
Corrigan, F., Černak, I., McAteer, K. M., Hellewell, S. C., Rosenfeld, J. V., Turner, R. J., & Vink, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-88237-0 · Cited by 27
Zheng, X., Mi, T., Wang, R., Zhang, Z., Li, W., Zhao, J., Yang, P., Xia, H., & Mao, Q. (2022) · Glia · doi:10.1002/glia.24175 · Cited by 29
The role of the stress system in recovery after traumatic brain injury: A tribute to Bruce S. McEwen
Weil, Z. M., White, B. A., Whitehead, B. J., & Karelina, K. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100467 · Cited by 29
Aß Pathology and Neuron–Glia Interactions: A Synaptocentric View
Huffels, C. F. M., Middeldorp, J., & Hol, E. M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03699-6 · Cited by 29
Necula, D., Cho, F. S., He, A., & Paz, J. T. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25259 · Cited by 27
Fernández‐Arjona, M. D. M., León‐Rodríguez, A., Grondona, J. M., & López-Ávalos, M. D. (2022) · Glia · doi:10.1002/glia.24217 · Cited by 28
Environmental and lifestyle risk factors for early-onset dementia: a systematic review.
Bosi, M., Malavolti, M., Garuti, C., Tondelli, M., Marchesi, C., Vinceti, M., & Filippini, T. (2022) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v93i6.13279 · Cited by 28
Hyperthermia and Mild Traumatic Brain Injury: Effects on Inflammation and the Cerebral Vasculature
Truettner, J. S., Bramlett, H. M., & Dietrich, W. D. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5303 · Cited by 26
Fryer, A. L., Abdullah, A., Mobilio, F., Jobling, A., Moore, Z., de Veer, M., Zheng, G., Wong, B., Taylor, J. M., & Crack, P. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16347 · Cited by 21
Buprenorphine alters microglia and astrocytes acutely following diffuse traumatic brain injury
Ryu, J., Stone, P., Lee, S., Payne, B., Gorse, K. M., & Lafrenaye, A. D. (2021) · Scientific Reports · doi:10.1038/s41598-021-88030-z · Cited by 26
Grovola, M. R., Paleologos, N., Brown, D. P., Tran, N., Wofford, K. L., Harris, J. P., Browne, K. D., Shewokis, P. A., Wolf, J. A., Cullen, D. K., et al. (2021) · Brain Pathology · doi:10.1111/bpa.12953 · Cited by 26
Revisiting the critical roles of reactive microglia in traumatic brain injury
Zhao, J., Zhou, Y., Zhou, C.-W., Zhan, K., Yang, M., Wen, M., & Zhu, L. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002420 · Cited by 30
Choi, B. Y., Lee, S. H., Choi, H., Lee, S., Yoon, H. S., Park, J. B., Chung, W., & Suh, S. W. (2019) · Translational research · doi:10.1016/j.trsl.2019.01.002 · Cited by 24
Soni, N., Mohamed, A. Z., Kurniawan, N. D., Borges, K., & Nasrallah, F. A. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.5972 · Cited by 24
Honig, M. G., Dorian, C. C., Worthen, J. D., Micetich, A. C., Mulder, I. A., Sanchez, K. B., Pierce, W. F., Mar, N. A. D., & Reiner, A. J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14711 · Cited by 26
Long-Term Cognitive Deficits After Traumatic Brain Injury Associated With Microglia Activation
Saba, E. S., Karout, M., Nasrallah, L., Kobeissy, F. H., Darwish, H., & Khoury, S. J. (2021) · Clinical Immunology · doi:10.1016/j.clim.2021.108815 · Cited by 24
Herrera, M. L., Feijóo‐Bandín, S., Champarini, L. G., Hereñú, C. B., & Bellini, M. J. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.07.023 · Cited by 24
The Role of Microglia in the Etiology and Evolution of Chronic Traumatic Encephalopathy
Makinde, H. M., Just, T. B., Cuda, C. M., Perlman, H., & Schwulst, S. J. (2017) · Shock · doi:10.1097/shk.0000000000000859 · Cited by 24
Grovola, M. R., Paleologos, N., Wofford, K. L., Harris, J. P., Browne, K. D., Johnson, V. E., Duda, J. E., Wolf, J. A., & Cullen, D. K. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1720-0 · Cited by 24
Pycnogenol protects CA3–CA1 synaptic function in a rat model of traumatic brain injury
Norris, C. M., Sompol, P. M., Roberts, K. N., Ansari, M. A., & Scheff, S. W. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.11.006 · Cited by 23
Traumatic Brain Injury Leads to Accelerated Atherosclerosis in Apolipoprotein E Deficient Mice
Wang, J., Su, E. J., Wang, H., Guo, C., Lawrence, D. A., & Eitzman, D. T. (2018) · Scientific Reports · doi:10.1038/s41598-018-23959-2 · Cited by 23
Reduced Neuron-Specific Enolase Levels in Chronic Severe Traumatic Brain Injury
Bagnato, S., Andriolo, M., Boccagni, C., Lucca, L. F., TANTI, A. D., Pistarini, C., Barone, T., & Galardi, G. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2019.6449 · Cited by 23
The contribution of the meningeal immune interface to neuroinflammation in traumatic brain injury
Mokbel, A. Y., Burns, M. P., & Main, B. S. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03122-7 · Cited by 25
Stress injuries and autophagy in mouse hippocampus after chronic cold exposure
Wang, L., Deng, J., Qu, T., Deng, J.-X., Li, R.-L., Cui, Z., & Wang, X. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.202932 · Cited by 22
Zheng, Z., Wu, Y.-Q., Li, Z., Ye, L.-X., Lu, Q., Zhou, Y., Yuan, Y., Jiang, T., Xie, L., Liu, Y.-L., et al. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14892 · Cited by 21
Deletion of PTEN in microglia ameliorates chronic neuroinflammation following repetitive mTBI
Pearson, A., Ortiz, C., Eisenbaum, M., Arrate, C., Browning, M., MULLAN, M. J., Bachmeier, C. J., Crawford, F., & Ojo, J. O. (2023) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103855 · Cited by 23
Neuroimaging of traumatic brain injury in military personnel: An overview
Bhattrai, A., Andrei Irimia, A., & Horn, J. D. V. (2019) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.07.001 · Cited by 23
Green, T. R. F., Murphy, S. M., Ortiz, J. B., & Rowe, R. K. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.804139 · Cited by 26
Zhao, L. (2019) · Journal of neurosurgery · doi:10.3171/2019.1.jns17878a · Cited by 22
Choi, B. Y., Hong, D. K., Kang, B. S., Lee, S. H., Choi, S., Kim, H., Lee, S. M., & Suh, S. W. (2023) · Pharmaceuticals · doi:10.3390/ph16030436 · Cited by 22
Makarava, N., Mychko, O., Molesworth, K., Chang, J. C., Henry, R. J., Tsymbalyuk, N., Gerzanich, V., Simard, J. M., Loane, D. J., & Baskakov, I. V. (2023) · Cells · doi:10.3390/cells12172172 · Cited by 19
Self-citationSatani, N., & Savitz, S. I. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0468-9 · Cited by 21
Schreiber, R., Hollands, R., & Blokland, A. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191010103044 · Cited by 21
Barlattani, T., Celenza, G., Cavatassi, A., Minutillo, F., Socci, V., Pinci, C., Santini, R., & Pacitti, F. (2024) · Current Neuropharmacology · doi:10.2174/011570159x343115241030094848 · Cited by 20
Mao, Y., Black, A. M. B., Milbourn, H., Krakonja, S., Nesbit, M., Bartlett, C. A., Fehily, B., Takechi, R., Yates, N. J., & Fitzgerald, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113408 · Cited by 20
Houle, S., & Kokiko‐Cochran, O. N. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.788055 · Cited by 22
Gandasasmita, N., Li, J., Loane, D. J., & Semple, B. D. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2023.0453 · Cited by 23
Self-citationGlial response in early stages of traumatic brain injury
Zhao, J., Wang, B., Huang, T., Guo, X., Yang, Z., Song, J., & Zhang, M. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134335 · Cited by 20
Shu, S., Zhang, Z., Spicer, D., Kulikowicz, E., Hu, K., Babapoor-Farrokhran, S., Kannan, S., Koehler, R. C., & Robertson, C. (2019) · Developmental Neuroscience · doi:10.1159/000500895 · Cited by 20
Henry, R. J., Meadows, V. E., Stoica, B. A., Faden, A. I., & Loane, D. J. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7139 · Cited by 20
Self-citationEpidemiology, Risk Factors, and Biomarkers of Post-Traumatic Epilepsy: A Comprehensive Overview
Kazis, D. A., Chatzikonstantinou, S., Ciobica, A. S., Kamal, F. Z., Burlui, V., Călin, G., & Mavroudis, I. A. (2024) · Biomedicines · doi:10.3390/biomedicines12020410 · Cited by 19
Cramer, S. W., Haley, S. P., Popa, L. S., Carter, R. E., Scott, E. P., Flaherty, E. B., Dominguez, J., Aronson, J. D., Sabal, L. T., Surinach, D. A., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105943 · Cited by 18
Corrigan, F., Arulsamy, A., Teng, J., & Collins‐Praino, L. E. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4589 · Cited by 20
TSPO Expression and Brain Structure in the Psychosis Spectrum
Hafizi, S., Guma, E., Koppel, A., Silva, T. D., Kiang, M., Houle, S., Wilson, A., Rusjan, P., Chakravarty, M., & Mizrahi, R. (2018) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2018.06.009 · Cited by 19
Dong, H., Zhang, H., Cai, L., Ye, Q., Wang, H., Liu, B., Zhang, W., & Li, J. (2024) · Biochemical Genetics · doi:10.1007/s10528-024-10980-6 · Cited by 20
Mehrabian, Z., Guo, Y., Weinreich, D. M., & Bernstein, S. L. (2017) · PubMed Central · Cited by 18
Park, E. Y., Lyon, J. G., Alvarado‐Velez, M., Betancur, M. I., Mokarram, N., Shin, J. H., & Bellamkonda, R. V. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24834 · Cited by 17
Kahriman, A., Bouley, J., Bosco, D. A., Shazeeb, M. S., & Henninger, N. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136430 · Cited by 18
Immune checkpoint inhibition perturbs neuro-immune homeostasis and impairs cognitive function
Ifejeokwu, O. V., Do, A. H., El-Khatib, S. M., Ho, N., Zavala, A., Othy, S., & Acharya, M. M. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03442-3 · Cited by 21
Abikenari, M. A., Ha, J. H., Liu, J., Ren, A. L., Cho, K. B., Lim, J., Kim, L. H., Medikonda, R. T., Choi, J. H., & Lim, M. K. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1668480 · Cited by 18
The NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury
Laabei, J., Vegliante, G., Strogulski, N. R., Douglas, C., Threja, S., Pearson, A., Nkiliza, A., Hanscom, M., Emediato, I. D. F., Crawford, F., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03535-y · Cited by 17
Self-citationHalicki, M. J., Hind, K., & Chazot, P. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612556 · Cited by 20
Puangmalai, N., Bhatt, N. N., Bittar, A., Jerez, C., Shchankin, N., & Kayed, R. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102562 · Cited by 17
Irvine, K., Bishop, R. K., Won, S. J., Xu, J., Hamel, K. A., Coppes, V. G., Singh, P., Sondag, A., Rome, E., Basu, J., et al. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5044 · Cited by 17
Hosomi, S., Watabe, T., Mori, Y., Koyama, Y., Adachi, S., Hoshi, N., Ohnishi, M., Ogura, H., Yoshioka, Y., Hatazawa, J., et al. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.09.031 · Cited by 17
Single cell RNA sequencing after moderate traumatic brain injury: effects of therapeutic hypothermia
Kerr, N. A., Choi, J. S., Mohite, S. Y., Singh, P. K., Bramlett, H. M., Lee, J. K., & Dietrich, W. D. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03430-6 · Cited by 16
Procès, A., Alpizar, Y. A., Halliez, S., Brône, B., Saudou, F., Ris, L., & Gabriele, S. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122426 · Cited by 17
Head trauma and Parkinson’s disease: results from an Italian case-control study
Nicoletti, A. S. Q., Vasta, R., Mostile, G., Nicoletti, G., Arabia, G., Iliceto, G., Lamberti, P., Marconi, R., Morgante, L., Barone, P., et al. (2017) · Neurological Sciences · doi:10.1007/s10072-017-3076-5 · Cited by 16
Effects of nicotinamide on spatial memory and inflammation after juvenile traumatic brain injury
Smith, A. C., Holden, R., Rasmussen, S. M., Hoane, M. R., & Hylin, M. J. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.024 · Cited by 16
Chen, Z., Islam, M. B. A. R., Ford, K. P., Zhao, G., Chen, S.-Y., Wang, Y., Davis, B. T., Mentis, A. A., & Schwulst, S. J. (2022) · Shock · doi:10.1097/shk.0000000000002027 · Cited by 18
Izzy, S., Brown-Whalen, A., Yahya, T., Sarro-Schwartz, A., Jin, G., Chung, J. Y., Lüle, S., Morsett, L. M., Alquraini, A., Wu, L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020907 · Cited by 16
Xing, Z., Zhen, T., Fan, J., Yu, J., Shiqi, L., Kaiyi, Z., Ouyang, Z., & Ming-yan, H. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.66494 · Cited by 16
Doust, Y. V., Bindoff, A. D., Holloway, O. G., Wilson, R., King, A. E., & Ziebell, J. M. (2022) · Glia · doi:10.1002/glia.24313 · Cited by 14
Thomsen, G. M., Vit, J.-P., Lamb, A., Gowing, G., Shelest, O., Alkaslasi, M., Ley, E. J., & Svendsen, C. N. (2015) · eneuro · doi:10.1523/eneuro.0059-14.2015 · Cited by 13
Deleterious effect of sustained neuroinflammation in pediatric traumatic brain injury
Jacquens, A., Csaba, Z., Soleimanzad, H., Bokobza, C., Delmotte, P.-R., Userovici, C., Boussemart, P., Chhor, V., Bouvier, D., van de Looij, Y., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.04.029 · Cited by 15
Generation and clearance of myelin debris after spinal cord injury
Li, C., Luo, W., Hussaın, I., Niu, R., He, X., Xiang, C., Guo, F., Liu, W., & Gu, R. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01405 · Cited by 17
Cytokines and related signaling pathways in traumatic brain injury
Zhu, L., Huang, S., Chen, W., Li, K., & Sheng, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1738589 · Cited by 18
Metadata
- Authors
- Loane, D. J., Kumar, A., Stoica, B. A., Cabatbat, R., & Faden, A. I.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Loane, David J.
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-01
- Volume
- 73
- Issue
- 1
- Pages
- 14-29
- ISSN
- 0022-3069 (ISSN-L)
- PMC
- PMC4267248
- OpenAlex
- W2067451082
- Cited by
- 498
- References
- 49
- Citations by year
- 2026: 35 · 2025: 28 · 2024: 42 · 2023: 39 · 2022: 39 · 2021: 68 · 2020: 56 · 2019: 42 · 2018: 36 · 2017: 41 · 2016: 31 · 2015: 24 · 2014: 17
- FWCI
- 15.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS037313, R01NS052568, R01NS082308)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- traumatic brain injury, progressive neurodegeneration, microglial activation, neuroinflammation, controlled cortical impact, lesion expansion, hippocampal neurodegeneration, demyelination, oxidative stress, NADPH oxidase, CD68
- MeSH terms
- Animals, Brain Injuries, Disease Models, Animal, Male, Mice, Inbred C57BL, Time Factors, Microglia, Disease Progression, Neurodegenerative Diseases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
