Cited by 250Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury Research

Microglia and Neuroinflammation: Crucial Pathological Mechanisms in Traumatic Brain Injury-Induced Neurodegeneration

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Shao, Fangjie, Wang, Xiaoyu, Wu, Haijian, Wu, Qun, Zhang, Jianmin·2022·Frontiers in Aging Neuroscience

Abstract

Traumatic brain injury (TBI) is one of the most common diseases in the central nervous system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many sequelae in the life time post injury, including neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). However, the pathological mechanisms connecting these two processes have not yet been fully elucidated. It is important to further investigate the pathophysiological mechanisms underlying TBI and TBI-induced neurodegeneration, which will promote the development of precise treatment target for these notorious neurodegenerative consequences after TBI. A growing body of evidence shows that neuroinflammation is a pivotal pathological process underlying chronic neurodegeneration following TBI. Microglia, as the immune cells in the CNS, play crucial roles in neuroinflammation and many other CNS diseases. Of interest, microglial activation and functional alteration has been proposed as key mediators in the evolution of chronic neurodegenerative pathology following TBI. Here, we review the updated studies involving phenotypical and functional alterations of microglia in neurodegeneration after injury, survey key molecules regulating the activities and functional responses of microglia in TBI pathology, and explore their potential implications to chronic neurodegeneration after injury. The work will give us a comprehensive understanding of mechanisms driving TBI-related neurodegeneration and offer novel ideas of developing corresponding prevention and treatment strategies for this disease.

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Authors
Shao, F., Wang, X., Wu, H., Wu, Q., & Zhang, J.
Affiliations
  • First Affiliated Hospital Zhejiang University (CN)
  • Second Affiliated Hospital of Zhejiang University (CN)
Corresponding author
  • Wu, Qun
  • Zhang, Jianmin
Venue
Frontiers in Aging Neuroscience
Published
2022-03-25
Volume
14
Pages
825086-825086
ISSN
1663-4365 (ISSN-L)
OpenAlex
W4220730682
Cited by
250
References
188
Citations by year
2026: 47 · 2025: 85 · 2024: 75 · 2023: 31 · 2022: 11
FWCI
5.21
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Aging Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords
traumatic brain injury, microglia, neuroinflammation, neurodegeneration, microglial activation, Alzheimer's disease, Parkinson's disease, chronic neurodegeneration, microglial phenotype, treatment options

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