Hyperphosphorylated Tau in the Occipital Cortex in Aged Nondemented Subjects
Abstract
To determine the extent of neurodegeneration of the visual association cortex, we assessed hyperphosphorylated tau-immunoreactive (HPtau-IR) neurofibrillary tangles in Brodmann Areas 18/19 in nondemented and demented subjects. At least occasional HPtau-IR neurofibrillary tangles were seen in 24% of 59 nondemented subjects with ages at death ranging from 42 to 87 years. The incidence increased to 41% in the 32 nondemented subjects who had HPtau-IR pathology in the hippocampal region. Demented subjects with Braak Stages 0 to III and corticobasal degeneration, frontotemporal lobar degeneration with TAR DNA binding protein 43, vascular cognitive impairment, or dementia with Lewy bodies also had HPtau-IR pathology in Brodmann Areas 18/19. These results support the concept that the occipital association area may have enhanced vulnerability to neurodegeneration. Neuropathologic assessment of these areas is, therefore, recommended, particularly in subjects suspected or known to have had mild cognitive impairment. Occasional HPtau-IR lesions were also seen in the medial temporal gyrus. Thus, the question as to whether scattered HPtau-IR lesions in either temporal or occipital cortex indicate a neurodegenerative disease remains unresolved. Further systematic clinicopathologic studies are needed for an understanding of regional susceptibility to neurodegeneration and the significance of scattered HPtau-IR brain lesions.
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Pathological tau has been reported in the occipital cortex of aged non-demented subjects.
“Additionally, pathological tau has been reported in the occipital cortex of aged non-demented subjects [28].”
From Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementia (2022) · cites this paper as [28]
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“Additionally, pathological tau has been reported in the occipital cortex of aged non-demented subjects [28].”
Background
- Authors
- Pikkarainen, M., Kauppinen, T., & Alafuzoff, I.
- Affiliations
- Kuopio University Hospital (FI)
- Venue
- Journal of Neuropathology and Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-06
- Volume
- 68
- Issue
- 6
- Pages
- 653-660
- ISSN
- 0022-3069 (ISSN-L)
- OpenAlex
- W2020206355
- Cited by
- 21
- References
- 22
- Citations by year
- 2025: 3 · 2022: 2 · 2021: 2 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 2
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kuopion Yliopistollinen Sairaala
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- hyperphosphorylated tau, neurofibrillary tangles, occipital cortex, visual association cortex, neurodegeneration, aging, dementia, Braak stages, corticobasal degeneration, frontotemporal lobar degeneration, vascular cognitive impairment, dementia with Lewy bodies, medial temporal gyrus, mild cognitive impairment
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Autopsy, Body Weight, Dementia, Female, Humans, Male, Middle Aged, Occipital Lobe, Phosphorylation, Chi-Square Distribution, Amyloid beta-Peptides, tau Proteins, Statistics, Nonparametric
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