The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Selective Upregulation of Scavenger Receptors in and Around Demyelinating Areas in Multiple Sclerosis
Abstract
Autoantibodies and complement opsonization have been implicated in the process of demyelination in the major human CNS demyelinating disease multiple sclerosis (MS), but scavenger receptors (SRs) may also play pathogenetic roles. We characterized SR mRNA and protein expression in postmortem brain tissue from 13 MS patients in relation to active demyelination. CD68, chemokine (C-X-C motif) ligand 16 (CXCL16), class A macrophage SR (SR-AI/II), LOX-1 (lectin-like oxidized low-density lipoprotein receptor 1), FcγRIII, and LRP-1 (low-density lipoprotein receptor-related protein 1) mRNA were upregulated in the rims of chronic active MS lesions. CD68 and CXCL16 mRNA were also upregulated around chronic active MS lesions. By immunohistochemistry, CD68, CXCL16, and SR-AI/II were expressed by foamy macrophages in the rim and by ramified microglia around chronic active MS lesions. CXCL16 and SR-AI/II were also expressed by astrocytes in MS lesions and by primary human microglia and astrocytes in vitro. These data suggest that SRs are involved in myelin uptake in MS, and that upregulation of CD68, CXCL16, and SR-AI/II is one of the initial events in microglia as they initiate myelin phagocytosis. As demyelination continues, additional upregulation of LOX-1, FcγRIII, and LRP-1 may facilitate this process.
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In the citing paper
“it is thought that microglial LPL is able to process myelin after which the myelin derived lipids can be taken up via scavenger receptors expressed on microglia (13).”
From Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity (2019) · cites this paper as [13]
In the citing paper
“These scavenger receptors have been suggested to involved in myelin phagocytosis and have been shown to be upregulated in and around demyelinating areas in MS tissue (13).”
From Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity (2019) · cites this paper as [13]
Citations
Cites
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Cited by
Sorted by citations
Luchetti, S., Fransen, N. L., van Eden, C. G., Ramaglia, V., Mason, M., & Huitinga, I. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1818-y · Cited by 355
Self-citationMerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells
Healy, L. M., Perron, G., Won, S.-Y., Michell-Robinson, M. A., Rezk, A., Ludwin, S. K., Moore, C. S., Hall, J. A., Bar-Or, A., & Antel, J. P. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502562 · Cited by 174
Mechanisms of white matter damage in multiple sclerosis
Lassmann, H. (2014) · Glia · doi:10.1002/glia.22597 · Cited by 191
Hendrickx, D. A. E., van Scheppingen, J., van der Poel, M., Bossers, K., Schuurman, K. G., van Eden, C. G., Hol, E. M., Hamann, J., & Huitinga, I. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01810 · Cited by 139
Self-citationThe Unique Phenotype of Lipid-Laden Macrophages
van Eijk, M., & Aerts, J. M. F. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084039 · Cited by 63
Metadata
- Authors
- Hendrickx, D. A. E., Koning, N., Schuurman, K. G., Strien, M. E. V., Eden, C. G. V., Hamann, J., & Huitinga, I.
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-02
- Volume
- 72
- Issue
- 2
- Pages
- 106-118
- ISSN
- 0022-3069
- 1554-6578
- Cited by
- 72
- References
- 2
- Language
- en
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- CoChat. (2026). Citation check: Selective Upregulation of Scavenger Receptors in and Around Demyelinating Areas in Multiple Sclerosis. https://app.cochat.ai/papers/10.1097/nen.0b013e31827fd9e8
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- Hendrickx, D. A. E., Koning, N., Schuurman, K. G., Strien, M. E. V., Eden, C. G. V., Hamann, J., & Huitinga, I. (2013). Selective Upregulation of Scavenger Receptors in and Around Demyelinating Areas in Multiple Sclerosis. Journal of Neuropathology & Experimental Neurology. https://doi.org/10.1097/nen.0b013e31827fd9e8
