New human immunodeficiency virus diagnosis independently associated with rectal gonorrhea and chlamydia in men who have sex with men.

Barbee, Lindley A.; Khosropour, Christine M.; Dombrowksi, Julia C.; Golden, Matthew R.

doi:10.1097/olq.0000000000000614

Cited by 92HIV/AIDS Research and InterventionsHIV, Drug Use, Sexual RiskReproductive tract infections research

New human immunodeficiency virus diagnosis independently associated with rectal gonorrhea and chlamydia in men who have sex with men.

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Barbee, Lindley A., Khosropour, Christine M., Dombrowksi, Julia C., Golden, Matthew R.·2017·Sexually Transmitted Diseases

DOI 10.1097/olq.0000000000000614PMC PMC5481158

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Abstract

BACKGROUND: Rectal sexually transmitted infections (STI) have been associated with human immunodeficiency virus (HIV) diagnosis, but inferring a causal association requires disentangling them from receptive anal intercourse (RAI). METHODS: We conducted a stratified case-control study by frequency matching 4 controls to each case within year using clinical data from men who have sex with men (MSM) attending the Seattle STD Clinic 2001 to 2014. Cases were MSM with a new HIV diagnosis and negative HIV test at 12 months or less. Controls were HIV-negative MSM. All included men had rectal STI testing, tested negative for syphilis, and had complete sexual behavior data. We categorized men by RAI: (1) none; (2) condoms for all RAI; (3) condomless RAI only with HIV-negative partners; and (4) condomless RAI with HIV-positive or unknown-status partners. We created 3 logistic regression models: (1) 3 univariate models of concurrent rectal gonorrhea, rectal chlamydia, and rectal STI in 12 months or less with new HIV diagnosis; (2) those 3 infections, plus age, race, year, number of sexual partners in 2 months or less, and methamphetamine use; and (3) model 2 with RAI categories. We calculated the population attributable risk of rectal STI on HIV diagnoses. RESULTS: Among 176 cases and 704 controls, rectal gonorrhea, chlamydia and rectal STI in 12 months or less were associated with HIV diagnosis. The magnitude of these associations attenuated in the second model, but persisted in model 3 (gonorrhea: adjusted odds ratio [aOR], 2.3; 95% confidence interval [CI], 1.3-3.8; chlamydia: aOR, 2.5; 95% CI, 1.5-4.3; prior STI: aOR, 3.0; 95% CI, 1.5-6.2). One in 7 HIV diagnoses can be attributed to rectal STI. CONCLUSIONS: Rectal STI are independently associated with HIV acquisition. These findings support the hypothesis that rectal STI play a biologically mediated causal role in HIV acquisition and support screening/treatment of STI for HIV prevention.

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Rectal gonorrhea and chlamydia are associated with HIV infection.
“Rectal gonorrhea and chlamydia are associated with HIV infection (82,207), and men with repeat rectal infections can be at substantially higher risk for HIV acquisition (208).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [207]

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[10]Dombrowski J Kerani R Golden M Routine CASI Increased Sexual History Completeness among MSM STD Clinic Patients CDC STD Prevention Conference Minneapolis, MN 2012

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Additional file 3 of Applying a novel approach to scoping review incorporating artificial intelligence: mapping the natural history of gonorrhoea
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Additional file 1 of Applying a novel approach to scoping review incorporating artificial intelligence: mapping the natural history of gonorrhoea
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Additional file 4 of Applying a novel approach to scoping review incorporating artificial intelligence: mapping the natural history of gonorrhoea
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Additional file 2 of Applying a novel approach to scoping review incorporating artificial intelligence: mapping the natural history of gonorrhoea
Whelan, J., Ghoniem, M., Médoc, N., Apicella, M., & Beck, E. C. (2021) · Figshare · doi:10.6084/m9.figshare.16576113
Additional file 5 of Applying a novel approach to scoping review incorporating artificial intelligence: mapping the natural history of gonorrhoea
Whelan, J., Ghoniem, M., Médoc, N., Apicella, M., & Beck, E. C. (2021) · Figshare · doi:10.6084/m9.figshare.16576122
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Authors: Barbee, L. A., Khosropour, C. M., Dombrowksi, J. C., & Golden, M. R.
Affiliations: Public Health – Seattle & King County (US)
Corresponding author: Barbee, Lindley A.
Khosropour, Christine M.
Dombrowksi, Julia C.
Golden, Matthew R.
ORCID: Barbee, Lindley A.
Khosropour, Christine M.
Golden, Matthew R.
Venue: Sexually Transmitted Diseases
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2017-07
Volume: 44
Issue: 7
Pages: 385-389
ISSN: 0148-5717 (ISSN-L)
1537-4521
DOI: 10.1097/olq.0000000000000614
PMC: PMC5481158
OpenAlex: W2607267328
Cited by: 92
References: 13
Citations by year: 2026: 2 · 2025: 9 · 2024: 11 · 2023: 7 · 2022: 12 · 2021: 24 · 2020: 7 · 2019: 13 · 2018: 4 · 2017: 3
FWCI: 5.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Sexually Transmitted Diseases (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (K23AI113185, T32AI007140, P30AI027757)
Topics: Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords: HIV acquisition, rectal gonorrhea, rectal chlamydia, men who have sex with men, receptive anal intercourse, condomless anal sex, HIV prevention, STI screening, population attributable risk
MeSH terms: Adult, Central Nervous System Stimulants, Chlamydia Infections, Gonorrhea, Humans, Male, Mass Screening, Methamphetamine, Rectal Diseases, Retrospective Studies, Sexual Partners, Urban Population, Washington, HIV Infections, Case-Control Studies, Condoms, Homosexuality, Male, Substance-Related Disorders

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New human immunodeficiency virus diagnosis independently associated with rectal gonorrhea and chlamydia in men who have sex with men.

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