Delirium in Children after Cardiac Bypass Surgery
Open accessAbstract
OBJECTIVES: To describe the incidence of delirium in pediatric patients after cardiac bypass surgery and explore associated risk factors and effect of delirium on in-hospital outcomes. DESIGN: Prospective observational single-center study. SETTING: Fourteen-bed pediatric cardiothoracic ICU. PATIENTS: One hundred ninety-four consecutive admissions following cardiac bypass surgery, 1 day to 21 years old. INTERVENTIONS: Subjects were screened for delirium daily using the Cornell Assessment of Pediatric Delirium. MEASUREMENTS AND MAIN RESULTS: Incidence of delirium in this sample was 49%. Delirium most often lasted 1-2 days and developed within the first 1-3 days after surgery. Age less than 2 years, developmental delay, higher Risk Adjustment for Congenital Heart Surgery 1 score, cyanotic disease, and albumin less than three were all independently associated with development of delirium in a multivariable model (all p < 0.03). Delirium was an independent predictor of prolonged ICU length of stay, with patients who were ever delirious having a 60% increase in ICU days compared with patients who were never delirious (p < 0.01). CONCLUSIONS: In our institution, delirium is a frequent problem in children after cardiac bypass surgery, with identifiable risk factors. Our study suggests that cardiac bypass surgery significantly increases children's susceptibility to delirium. This highlights the need for heightened, targeted delirium screening in all pediatric cardiothoracic ICUs to potentially improve outcomes in this vulnerable patient population.
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Delirium prevalence is estimated to be as high as 49% to 57% in children with cyanotic disease, longer durations of mechanical ventilation, and long cardiopulmonary bypass times.
“Given that delirium pathophysiology is directly linked to the underlying medical condition, its prevalence is tightly related to the population under study, estimated to be as high as 49% to 57% in children with cyanotic disease, longer durations of mechanical ventilation, and long cardiopulmonary bypass times [67,68].”
From Psychological and Psychiatric Comorbidities in Youth with Serious Physical Illness (2022) · cites this paper as [68]
The Abstract’s Measurements and Main Results report 49% delirium incidence in the overall cardiac-bypass sample. The Results associate delirium with cyanotic disease and longer bypass time, and report longer mechanical ventilation among children who developed delirium. The paper does not establish a 49%–57% prevalence specifically among children with those characteristics, nor does it report 57%. (LLM, conf=0.86)
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Electronic health records identify timely trends in childhood mental health conditions
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- Authors
- Patel, A. K., Biagas, K. V., Clarke, E. C., Gerber, L. M., Mauer, E., Silver, G., Chai, P., Corda, R., & Traube, C.
- Affiliations
- NewYork–Presbyterian Hospital (US)
- Columbia University Irving Medical Center (US)
- Weill Cornell Medicine (US)
- Columbia University (US)
- ORCID
- Venue
- Pediatric Critical Care Medicine
- Published
- 2017-02
- Volume
- 18
- Issue
- 2
- Pages
- 165-171
- ISSN
- 1529-7535 (ISSN-L)
- PMC
- PMC5658045
- OpenAlex
- W2562671849
- Cited by
- 164
- References
- 25
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 28 · 2023: 19 · 2022: 16 · 2021: 22 · 2020: 16 · 2019: 14 · 2018: 12 · 2017: 8
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pediatric Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000457)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Keywords
- delirium, pediatric cardiac surgery, cardiac bypass surgery, risk factors, incidence, ICU length of stay, developmental delay, cyanotic congenital heart disease, albumin, Cornell Assessment of Pediatric Delirium, delirium screening
- MeSH terms
- Adolescent, Cardiopulmonary Bypass, Child, Child, Preschool, Delirium, Female, Humans, Infant, Infant, Newborn, Length of Stay, Male, Postoperative Complications, Prognosis, Prospective Studies, Respiration, Artificial, Risk Factors, Intensive Care Units, Pediatric, Incidence, Logistic Models
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