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Cited by 112Central Venous Catheters and HemodialysisNosocomial Infections in ICUInfective Endocarditis Diagnosis and Management

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Risk factors for central line-associated bloodstream infection in a pediatric cardiac intensive care unit

Costello, John M., Graham, Dionne A., Morrow, Debra Forbes, Potter-Bynoe, Gail, Sandora, Thomas J., Laussen, Peter C.·2009·Pediatric Critical Care Medicine
DOI 10.1097/pcc.0b013e318198b19a
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Abstract

Objective To identify risk factors for central line-associated bloodstream infection (BSI) in patients receiving care in a pediatric cardiac intensive care unit. Design Matched case-control study. Setting CICU at Children's Hospital Boston. Patients Central line-associated BSI cases were identified between April 2004 and December 2006. We identified two randomly selected control patients who had a central vascular catheter and were admitted within 7 days of each index case. Measurements and main results Univariate and multivariate conditional logistic regression analyses were used to identify risk factors for central line-associated BSI. In a secondary analysis, risk factors for central line-associated BSI in those cases who underwent cardiac surgery were sought. During the study period, 67 central line-associated BSIs occurred in 61 patients. Independent risk factors for central line-associated BSI were nonelective admission for medical management (odds ratio [OR] = 6.51 [1.58-26.78]), the presence of noncardiac comorbidities (OR = 4.95 [1.49-16.49]), initial absolute neutrophil count or =3 units (OR = 5.56 [1.35-22.87]), central line days > or =7 (OR = 6.06 [1.65-21.83]), and use of hydrocortisone (OR = 28.94 [2.55-330.37]). In those patients who underwent cardiac surgery (n = 37 cases and 108 controls), independent risk factors for central line-associated BSI were admission weight or =15 (OR = 3.44 [1.19-9.92]), blood product exposure > or =3 units (OR = 3.38 [1.28-11.76])…

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Metadata

Authors
Costello, J. M., Graham, D. A., Morrow, D. F., Potter-Bynoe, G., Sandora, T. J., & Laussen, P. C.
Affiliations
Boston Children's Hospital (US)
ORCID
Venue
Pediatric Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-07
Volume
10
Issue
4
Pages
453-459
ISSN
1529-7535 (ISSN-L)
DOI
10.1097/pcc.0b013e318198b19a
OpenAlex
W1996570654
Cited by
112
References
0
Citations by year
2026: 1 · 2024: 6 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 10 · 2016: 7 · 2015: 4 · 2014: 8 · 2013: 10 · 2012: 12
FWCI
12.23
Type
journal article
Language
en
Open access
closed
Locations
  • Pediatric Critical Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Central Venous Catheters and Hemodialysis
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Infective Endocarditis Diagnosis and Management
Keywords
central line-associated bloodstream infection, pediatric cardiac intensive care, risk factors, central venous catheters, cardiac surgery, cortisol, blood product exposure, mechanical ventilation, neutropenia, device-related infection, pediatric congenital heart disease, nosocomial infection prevention, catheter dwell time
MeSH terms
Catheterization, Central Venous, Cross Infection, Female, Heart Defects, Congenital, Heart Diseases, Cardiac Surgical Procedures, Humans, Infant, Infant, Newborn, Male, Risk Factors, Time Factors, Intensive Care Units, Pediatric, Comorbidity, Case-Control Studies, Bacteremia, Catheter-Related Infections

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CoChat. (2026). Citation check: Risk factors for central line-associated bloodstream infection in a pediatric cardiac intensive care unit. https://app.cochat.ai/papers/10.1097/pcc.0b013e318198b19a
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Costello, J. M., Graham, D. A., Morrow, D. F., Potter-Bynoe, G., Sandora, T. J., & Laussen, P. C. (2009). Risk factors for central line-associated bloodstream infection in a pediatric cardiac intensive care unit. Pediatric Critical Care Medicine. https://doi.org/10.1097/pcc.0b013e318198b19a