The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Serous Carcinogenesis in the Fallopian Tube: A Descriptive Classification
Abstract
The fimbria is the most common site of early serous cancer (tubal intraepithelial carcinoma or STIC) in women with BRCA mutations (BRCA+). A candidate serous cancer precursor--the p53 signature--has been found in nonneoplastic secretory cells of the fimbria, suggesting serous carcinogenesis in the tube (SCAT). This study surveyed fallopian tubes from 3 populations to characterize the morphological and immunohistochemical correlates of SCAT. The SCAT sequence was defined by strong nuclear p53 staining and DNA damage (gamma-H2AX+) in secretory cells and subdivided morphologically by (1) degree of nuclear stratification, (2) proliferative index, and (3) degree of disorganized growth. Fallopian tubes from women without a current ovarian cancer, women with BRCA mutations, and women with a coexisting pelvic serous cancer were completely examined. p53 signatures exhibited cuboidal to pseudostratified, polarized p53+ epithelial segments with variable nuclear enlargement and a MiB1 index of 0% to 30%. Tubal intraepithelial carcinomas contained from single (uncommon) to multilayered, poorly polarized, uninterrupted neoplastic cell populations that completely displaced the normal mucosa; MiB1 index exceeded 45% and was usually more than 70%. An uncommon third category, p53-positive foci with features intermediate between p53 signatures and STICs, exhibited preserved epithelial polarity, pseudostratification, incomplete replacement of the adjacent normal ciliated cells, and a MiB1 index between 40% and 75%. Transitions from 1 category to another were documented. Combined with recent reports associating STICs with pelvic serous cancer, this continuum of epithelial change validates the SCAT sequence and the fimbrial secretory cell as the site of origin for many serous carcinomas.
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Self-citationA candidate precursor to serous carcinoma that originates in the distal fallopian tube
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Pathologic Findings in Prophylactic Oophorectomy Specimens in High-Risk Women
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Chromatin in Need of a Fix: Phosphorylation of H2AX Connects Chromatin to DNA Repair
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BRCA-Mutation–Associated Fallopian Tube Carcinoma: A Distinct Clinical Phenotype?
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Cited by
Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—Shifting the paradigm
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Cell surface protein glycosylation in cancer
Christiansen, M. N., Chik, J., Lee, L., Anugraham, M., Abrahams, J. L., & Packer, N. H. (2014) · PROTEOMICS · doi:10.1002/pmic.201300387 · Cited by 518
New Insights Into the Pathogenesis of Serous Ovarian Cancer and Its Clinical Impact
Levanon, K., Crum, C., & Drapkin, R. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.1107 · Cited by 412
Self-citationNew insights into ovarian cancer pathology
Prat, J. (2012) · Annals of Oncology · doi:10.1093/annonc/mds300 · Cited by 317
Complex Determinants of Epithelial: Mesenchymal Phenotypic Plasticity in Ovarian Cancer
Klymenko, Y., Kim, O., & Stack, M. (2017) · Cancers · doi:10.3390/cancers9080104 · Cited by 99
Metadata
- Authors
- Jarboe, E., Folkins, A., Nucci, M. R., Kindelberger, D., Drapkin, R., Miron, A., Lee, Y., & Crum, C. P.
- Venue
- International Journal of Gynecological Pathology
- Published
- 2008-01
- Volume
- 27
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0277-1691 (ISSN-L)
- OpenAlex
- W2033501360
- Cited by
- 273
- References
- 15
- FWCI
- 24.78
- Type
- journal article
- Language
- en
- Open access
- closed
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