Cited by 325Gut microbiota and healthProbiotics and Fermented FoodsGastrointestinal motility and disorders

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Brain-Gut-Microbiota Axis and Mental Health

Dinan, Timothy G., Cryan, John F.·2017·Psychosomatic Medicine

Open this paper in CoChat — free account

Abstract

OBJECTIVE: The brain-gut-microbiota axis has been put forward as a new paradigm in neuroscience, which may be of relevance to mental illness. The mechanisms of signal transmission in the brain-gut-microbiota axis are complex and involve bidirectional communications that enable gut microbes to communicate with the brain and the brain to communicate with the microbes. This review assesses the potential usefulness and limitations of the paradigm. METHODS: A selective literature review was conducted to evaluate the current knowledge in clinical and preclinical brain-gut-microbiota interactions as related to psychiatric disorders. RESULTS: Most published studies in the field are preclinical, and there is so far a lack of clinical studies. Preliminary studies in psychiatric populations support the view of a dysbiosis in some conditions, but studies are often small scale and marred by potential confounding variables. Preclinical studies support the view that psychobiotics ("bacteria which when ingested in adequate amounts have a positive mental health benefit") might be of use in treating some patients with mental health difficulties. To date, we have no well-conducted studies in clinical populations, although there are some studies in healthy volunteers. A cocktail of probiotics has been shown to alter brain activity as monitored by functional magnetic resonance imaging, and Bifidobacterium longum was reported to alter brain electrical activity. CONCLUSIONS: It has yet to be convincingly demonstrated that the exciting findings of psychobiotic efficacy demonstrated in preclinical models of psychiatric illness will translate to patients.

Integrity signals

Registry

Crossref · 10.1097/psy.0000000000000519

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Self-citation
Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat
Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683
Self-citation
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342
Psychobiotics: A novel class of psychotropic
Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287
Self-citation
Consumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192
Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring
Buffington, S. A., Di Prisco, G. V., Auchtung, T. A., Ajami, N. J., Petrosino, J. F., & Costa-Mattioli, M. (2016) · Cell · doi:10.1016/j.cell.2016.06.001 · Cited by 1,163
The microbiome-gut-brain axis in health and disease
Dinan, T. G., & Cryan, J. F. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.09.007 · Cited by 1,111
Self-citation
Microbiota and neurodevelopmental windows: implications for brain disorders
Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089
Self-citation

Show all 65 references

Research works printed but not linked: 1

1953, The use of largactil in psychiatry, Geneeskd Gids, 31, 499

Sorted by citations

Items 101–200 of 325

Additional advances related to the health benefits associated with kombucha consumption
Esatbeyoglu, T., Aydin, S. S., Subaşı, B. G., Erskine, E., Gök, R., Ibrahim, S. A., Yılmaz, B., Özoğul, F., & Çapanoğlu, E. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2163373 · Cited by 38
Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice
Acharya, K. D., Graham, M. E., Raman, H. N., Parakoyi, A. E. R., Corcoran, A., Belete, M. K., Ramaswamy, B., Koul, S., Sachar, I., Derendorf, K., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-31783-6 · Cited by 35
Gut microbiome in alcohol use disorder: Implications for health outcomes and therapeutic strategies-a literature review
Koutromanos, I., Legaki, E., Gazouli, M., Vasilopoulos, E., Kouzoupis, A. V., & Tzavellas, E. (2024) · World Journal of Methodology · doi:10.5662/wjm.v14.i1.88519 · Cited by 35
Microglial depletion and abnormalities in gut microbiota composition and short-chain fatty acids in mice after repeated administration of colony stimulating factor 1 receptor inhibitor PLX5622
Yang, Y. H., Ishima, T., Wan, X., Wei, Y., Chang, L., Zhang, J., Qu, Y., & Hashimoto, K. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01325-0 · Cited by 32
Comparative analysis of gut microbiota and fecal metabolome features among multiple depressive animal models
Liu, X., Li, X., Teng, T., Jiang, Y., Xiang, Y., Fan, L., Yu, Y., Zhou, X., & Xie, P. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.06.088 · Cited by 33
Phage community involvement in fermented beverages: an open door to technological advances?
Ledormand, P., Desmasures, N., & Dalmasso, M. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1790497 · Cited by 35
Dietary Strategies to Improve Exercise Performance by Modulating the Gut Microbiota
Zhang, L., Li, H., Song, Z., Liu, Y., & Zhang, X. (2024) · Foods · doi:10.3390/foods13111680 · Cited by 34
Depressive hypertension: A proposed human endotype of brain/gut microbiome dysbiosis
Stevens, B. R., Pepine, C. J., Richards, E. M., Kim, S., & Raizada, M. K. (2021) · American Heart Journal · doi:10.1016/j.ahj.2021.05.002 · Cited by 30
Analysis of Conjunctival Sac Microbiome in Dry Eye Patients With and Without Sjögren's Syndrome
Song, H., Xiao, K., Chen, Z., & Long, Q. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.841112 · Cited by 29
The Gut and Its Microbiome as Related to Central Nervous System Functioning and Psychological Well-being: Introduction to the Special Issue of Psychosomatic Medicine
Mayer, E. A., & Hsiao, E. Y. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000525 · Cited by 29
Effects of Lactobacillus gasseri CP2305 on Mild Menopausal Symptoms in Middle-Aged Women
Sawada, D., Sugawara, T., Hirota, T., & Nakamura, Y. (2022) · Nutrients · doi:10.3390/nu14091695 · Cited by 31
Depression and the Aberrant Intestinal Microbiome.
Kopera, A. F., Khiew, Y. C., Alsamman, M. A., Mattar, M. C., Olsen, R. S., & Doman, D. B. (2024) · PubMed Central · Cited by 28
Cognition and gut microbiota in schizophrenia spectrum and mood disorders: A systematic review
Frileux, S., Boltri, M., Dore, J. M., Leboyer, M., & Roux, P. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105722 · Cited by 27
Gut Steroids and Microbiota: Effect of Gonadectomy and Sex
Diviccaro, S., FitzGerald, J. A., Cioffi, L., Falvo, E., Crispie, F., Cotter, P. D., O’Mahony, S. M., Giatti, S., Caruso, D., & Melcangi, R. C. (2022) · Biomolecules · doi:10.3390/biom12060767 · Cited by 28
Toward a Biopsychosocial Ecology of the Human Microbiome, Brain-Gut Axis, and Health
Maier, K. J., & Al’Absi, M. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000515 · Cited by 27
Measuring the Brain-Gut Axis in Psychological Sciences: A Necessary Challenge
Palacios-García, I., & Parada, F. J. (2020) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2019.00073 · Cited by 31
Comorbidities of Patients with Functional Somatic Syndromes Before, During and After First Diagnosis: A Population-based Study using Bavarian Routine Data
Donnachie, E., Schneider, A., & Enck, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-66685-4 · Cited by 27
Alterations and correlations of gut microbiota, fecal, and serum metabolome characteristics in a rat model of alcohol use disorder
Wang, X., Li, L., Bian, C., Bai, M., Yu, H., Gao, H., Zhao, J., Zhang, C., & Zhao, R. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1068825 · Cited by 28
Metabolic Alterations in the Outer Membrane Vesicles of Patients with Alzheimer’s Disease: An LC-MS/MS-based Metabolomics Analysis
Wei, S., Wei, W., Peng, W., Liu, Z., Cai, Z., & Zhao, B. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666191121141352 · Cited by 27
The “Biology‐First” Hypothesis: Functional disorders may begin and end with biology—A scoping review
Enck, P., & Mazurak, N. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13394 · Cited by 26
Inverse association between dietary fiber intake and depression in premenopausal women: a nationwide population-based survey
Kim, Y., Hong, M., Kim, S., Shin, W.-Y., & Kim, J. (2020) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001711 · Cited by 25
Psychobiotics: Evolution of Novel Antidepressants
Dinan, T. G., Butler, M., & Cryan, J. F. (2021) · Modern trends in psychiatry · doi:10.1159/000510424 · Cited by 26
Self-citation
Queen bee larva consumption improves sleep disorder and regulates gut microbiota in mice with PCPA-induced insomnia
Tang, Q., Xiong, J., Wang, J., Cao, Z., Liao, S.-Q., Xiao, Y., Tian, W., & Guo, J. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101256 · Cited by 25
Hyperbaric oxygen improves depression‐like behaviors in chronic stress model mice by remodeling gut microbiota and regulating host metabolism
Zhang, B., Dong, W., Ma, Z., Duan, S., Han, R., Zhou, L., Liu, X., & Mao, Y. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13999 · Cited by 24
A Healthy Gut for a Healthy Brain: Preclinical, Clinical and Regulatory Aspects
Petrella, C., Vecchioli, S. F., Cisale, G. Y., Strimpakos, G., Borg, J.-J., Ceccanti, M., Fiore, M., Monteleone, G., & Nisticò, R. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200730111528 · Cited by 24
Protective effect of scorpion venom heat-resistant synthetic peptide against PM2.5-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway
Xu, X., Xu, H., Ren, F., Huang, L., Xu, J., & Li, F. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577567 · Cited by 24
Stress and the Role of the Gut–Brain Axis in the Pathogenesis of Schizophrenia: A Literature Review
Vafadari, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189747 · Cited by 25
Polysaccharide Regulation of Intestinal Flora: A Viable Approach to Maintaining Normal Cognitive Performance and Treating Depression
Xinzhou, W., Cheng, L., Liu, Y., Zhang, R., Wu, Z., Weng, P., Zhang, P., & Zhang, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.807076 · Cited by 24
The schizophrenia and gut microbiota: A bibliometric and visual analysis
Yang, C., Lin, X., Wang, X., Liu, H., Huang, J., & Wang, S. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1022472 · Cited by 26
Intestinal microbiome and its potential functions in bighead carp ( Aristichthys nobilis ) under different feeding strategies
Li, X., Zhu, Y., Ringø, E., Wang, X., Gong, J., & Yang, D. (2018) · PeerJ · doi:10.7717/peerj.6000 · Cited by 24
Exploring the dynamics of perioperative symptom networks in colorectal cancer patients: a cross-lagged panel network analysis
Shang, B., Bian, Z., Luo, C., Lv, F., Wu, J., Lv, S., & Wei, Q. (2023) · Supportive Care in Cancer · doi:10.1007/s00520-023-08288-z · Cited by 25
Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology
Beltrán-Velasco, A. I., & Clemente‐Suárez, V. J. (2025) · Biomimetics · doi:10.3390/biomimetics10020073 · Cited by 25
Exposure to antibiotics during pregnancy alters offspring outcomes
Qu, W., Liu, L., & Miao, L. (2021) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1974000 · Cited by 25
Current Research in Fermented Foods: Bridging Tradition and Science
Sampsell, K., Marcolla, C. S., Tapping, S., Fan, Y., Sánchez-Lafuente, C. L., Willing, B. P., Reimer, R. A., & Burton, J. P. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100554 · Cited by 28
Connecting the dots: Targeting the microbiome in drug toxicity
Luo, Y., & Zhou, T. (2021) · Medicinal Research Reviews · doi:10.1002/med.21805 · Cited by 20
Microbiota-gut-brain axis and ketogenic diet: how close are we to tackling epilepsy?
Mengoli, M., Conti, G., Fabbrini, M., Candela, M., Brigidi, P., Turroni, S., & Barone, M. (2023) · Microbiome Research Reports · doi:10.20517/mrr.2023.24 · Cited by 23
Probiotic treatment (Bifidobacterium longum subsp. longum 35624™) affects stress responsivity in male rats after chronic corticosterone exposure
Haas, G. S., Wang, W., Saffar, M., Mooney‐Leber, S. M., & Brummelte, S. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112718 · Cited by 21
Biological Consequences of Psychological Distress in Caregivers of Children with Autism Spectrum Disorder and its Potential Relevance to Other Chronic Diseases Including Cancer
Neijs, L. D.-D., Leenen, P. J. M., Hays, J. P., van der Valk, E. S., Kraaij, R., van Rossum, E. F. C., & Ester, W. A. (2020) · Current Epidemiology Reports · doi:10.1007/s40471-020-00237-2 · Cited by 23
Microbiota Alters and Its Correlation with Molecular Regulation Underlying Depression in PCOS Patients
Yu, L., Chen, X., Bai, X., Fang, J., & Sui, M. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03744-7 · Cited by 20
The microbiome and mental health: Hope or hype?
Taylor, V. H. (2019) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.190110 · Cited by 22
The Translational Future of Stress Neurobiology and Psychosis Vulnerability: A Review of the Evidence
Cullen, A. E., Labad, J., Oliver, D., Al‐Diwani, A., Minichino, A., & Fusar‐Poli, P. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230322145049 · Cited by 25
Prebiotics Mitigate the Detrimental Effects of High-Fat Diet on memory, anxiety and microglia functionality in Ageing Mice
Vijaya, A. K., Kuras, S., Šimoliūnas, E., Mingaila, J., Makovskytė, K., Buišas, R., Daliri, E. B., Meškys, R., Baltriukienė, D., & Burokas, A. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.08.022 · Cited by 22
Age-Dependent Gut Microbiome Dysbiosis in Autism Spectrum Disorder and the Role of Key Bacterial Ratios
Kadiyska, T., Vassilev, D. I., Tourtourikov, I., Ciurinskiene, S., Madzharova, D., Savcheva, M., Stoynev, N., Mileva-Popova, R., Tafradjiiska-Hadjiolova, R. K., & Mitev, V. (2025) · Nutrients · doi:10.3390/nu17111775 · Cited by 23
Probiotics-targeting new milestones from gut health to mental health
Dey, G., & Mookherjee, S. (2021) · FEMS Microbiology Letters · doi:10.1093/femsle/fnab096 · Cited by 18
Impact of Enteric Nervous Cells on Irritable Bowel Syndrome: Potential Treatment Options
Pastras, P., Aggeletopoulou, I., & Triantos, C. K. (2024) · Microorganisms · doi:10.3390/microorganisms12102036 · Cited by 18
Nutritional Psychology: Review the Interplay Between Nutrition and Mental Health
Horovitz, O. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae158 · Cited by 22
Diet and Neurocognition in Mood Disorders - An Overview of the Overlooked
Balanzá‐Martínez, V., Shansis, F., Tatay-Manteiga, A., & López-García, P. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200318152530 · Cited by 20
Prenatal exposure to the probiotic Lactococcus lactis decreases anxiety-like behavior and modulates cortical cytoarchitecture in a sex specific manner.
Surzenko, N., Pjetri, E., Munson, C. A., Friday, W. B., Hauser, J., & Mitchell, E. S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0223395 · Cited by 18
Gut-Brain Axis: Probiotic,Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System
Cheng, H.-W., Jiang, S., & Hu, J. (2019) · Oral Health by Using Probiotic Products · doi:10.5772/intechopen.86775 · Cited by 17
Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance
Hoeferlin, G. F., Bajwa, T. S., Olivares, H., Zhang, J., Druschel, L. N., Sturgill, B. S., Sobota, M., Boucher, P., Duncan, J., Hernandez-Reynoso, A. G., et al. (2023) · Micromachines · doi:10.3390/mi14101902 · Cited by 16
Exploring the Association between Anxiety, Depression, and Gut Microbiota during Pregnancy: Findings from a Pregnancy Cohort Study in Shijiazhuang, Hebei Province, China
Chi, R., Li, M., Zhang, M., Zhang, N., Zhang, G., Cui, L., & Ma, G. (2024) · Nutrients · doi:10.3390/nu16101460 · Cited by 18
Liuwei Dihuang Decoction Alleviates Cognitive Dysfunction in Mice With D-Galactose-Induced Aging by Regulating Lipid Metabolism and Oxidative Stress via the Microbiota-Gut-Brain Axis
Liu, B., Chen, B., Yi, J., Long, H., Wen, H., Tian, F., Liu, Y., Xiao, L., & Li, L. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.949298 · Cited by 18
Involvement of the Intestinal Microbiota in the Appearance of Multiple Sclerosis: Aloe vera and Citrus bergamia as Potential Candidates for Intestinal Health
Maiuolo, J., Musolino, V., Gliozzi, M., Carresi, C., Scarano, F., Nucera, S., Scicchitano, M., Oppedisano, F., Bosco, F., Macrì, R., et al. (2022) · Nutrients · doi:10.3390/nu14132711 · Cited by 16
Synergistic and antagonistic interactions between antibiotics and synbiotics in modifying the murine fecal microbiome
Jačan, A., Kashofer, K., Zenz, G., Fröhlich, E. E., Reichmann, F., Hassan, A. M., & Holzer, P. D. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02035-z · Cited by 16
Targeting inflammation and gut microbiota with antibacterial therapy: implications for central nervous system health
Wei, J., Liu, C., Qin, D., Ren, F., Duan, J., Chen, T., & Wu, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102544 · Cited by 15
A systematic review of the effects of gut microbiota depletion on social and anxiety-related behaviours in adult rodents: Implications for translational research.
Olavarría‐Ramírez, L., Cooney-Quane, J., Murphy, G., McCafferty, C. P., Cryan, J. F., & Dockray, S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.105013 · Cited by 17
Self-citation
Applied human neuroscience: Fostering and designing inclusive environments with the 3E‐Cognition perspective
Parada, F. J., Grasso‐Cladera, A., Rossi, A., Soto‐Icaza, P., Arenas‐Pérez, M., & Errázuriz, M. C. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16463 · Cited by 16
A narrative review examining the relationship between mental health, physical activity, and nutrition
de Pinho, I. C., Giorelli, G., & Toledo, D. O. (2024) · Discover Psychology · doi:10.1007/s44202-024-00275-7 · Cited by 18
Integrated untargeted fecal metabolomics and gut microbiota strategy for screening potential biomarkers associated with schizophrenia
Gao, Y., Liu, X., Pan, M., Zeng, D., Zhou, X., Tsunoda, M., Zhang, Y., Xi, X., Wang, R., Hu, W., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.10.072 · Cited by 16
Gut Microbes and Neuropathology: Is There a Causal Nexus?
Dinan, K., & Dinan, T. G. (2022) · Pathogens · doi:10.3390/pathogens11070796 · Cited by 15
Self-citation
Fecal microbiota transplantation confirmed that 919 Syrup reduced the ratio of erucamide to 5-AVAB in hippocampus to alleviate postpartum depression by regulating gut microbes
Zheng, Q., Wang, S., Tian, X.-Y., Liu, W., & Gao, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1203015 · Cited by 14
Joint embedding of biological networks for cross-species functional alignment
Li, L., Dannenfelser, R., Zhu, Y., Hejduk, N., Segarra, S., & Yao, V. (2023) · Bioinformatics · doi:10.1093/bioinformatics/btad529 · Cited by 15
Citrus tangerine pith extract alleviates hypoxia-induced ileum damage in mice by modulating intestinal microbiota
Yu, Y., Li, R., Pu, L., Pan, C., Guo, C., & Wang, X. (2023) · Food & Function · doi:10.1039/d3fo01096a · Cited by 13
Reproducible microbiome composition signatures of anxiety and depressive symptoms
Kouraki, A., Kelly, A., Vijay, A., Gohir, S. A., Astbury, S., Georgopoulos, V., Millar, B., Walsh, D. A., Ferguson, E., Menni, C., et al. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.10.035 · Cited by 14
Clinical and Neurobiological Aspects of TAO Kinase Family in Neurodevelopmental Disorders
Hu, C., Feng, P., Yang, Q., & Xiao, L. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.655037 · Cited by 13
The psychobiotic revolution: comprehending the optimistic role of gut microbiota on gut-brain axis during neurological and Gastrointestinal (GI) disorders
Mohiuddin, M., Asghar, T., Hameed, H., Din, A. M., Siddique, A., Younas, S., Din, M. M. U., & Ara, R. (2025) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-025-04632-z · Cited by 13
Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis
Wang, S., Cai, Q., Xu, L., Sun, Y., Wang, M., Wang, Y., Zhang, L., Li, K., & Ni, Z. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06413-8 · Cited by 13
Chronic variable stress leads to sex specific gut microbiome alterations in mice
Kropp, D. R., Rainville, J. R., Glover, M. E., Tsyglakova, M., Samanta, R., Hage, T. R., Carlson, A. E., Clinton, S. M., & Hodes, G. E. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100755 · Cited by 12
Oral microbiome diversity shapes the association between sleep duration and depression
Liu, Y., Zhang, L., Yang, C., Zhi, L., Xu, X. S., & Yuan, M. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1442557 · Cited by 12
Preventive strategies for adolescent depression: What are we missing? A focus on biomarkers
Zonca, V. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100385 · Cited by 13
Acute and Delayed Effects of Stress Eliciting Post-Traumatic Stress-Like Disorder Differentially Alters Fecal Microbiota Composition in a Male Mouse Model
Hoke, A. V., Chakraborty, N., Gautam, A., Hammamieh, R., & Jett, M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.810815 · Cited by 14
Komagataella pastoris KM71H Mitigates Depressive-Like Phenotype, Preserving Intestinal Barrier Integrity and Modulating the Gut Microbiota in Mice
Birmann, P. T., Casaril, A. M., Pesarico, A. P., Rodrigues, R. R., Conceição, F. R., Sousa, F. S. S., Collares, T. V., Seixas, F. K., & Savegnago, L. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03326-7 · Cited by 13
The Impact of Air Pollution on Gut Microbiota and Children’s Health: An Expert Consensus
Fadlyana, E., Soemarko, D. S., Endaryanto, A., Haryanto, B., Darma, A., Dewi, D. K., Chandra, D. N., Hartono, B., Buftheim, S., Wasito, E., et al. (2022) · Children · doi:10.3390/children9060765 · Cited by 13
Association of the consumption of common drinks with early puberty in both sexes
Tsai, M., Lee, Y. L., & Chen, Y. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.854477 · Cited by 11
Contributions of Lactobacillus plantarum PC170 administration on the recovery of gut microbiota after short-term ceftriaxone exposure in mice
Cheng, R., Liang, H., Zhang, Y., Guo, J., Miao, Z., Shen, X. P., Chen, G., Cheng, G., Li, M., & He, F. (2020) · Beneficial Microbes · doi:10.3920/bm2019.0191 · Cited by 11
Beyond the neuro-immune interplay in depression: Could gut microbes be the missing link?
Audet, M. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100308 · Cited by 12
Music-based interventions in the feeding environment on the gut microbiota of mice
Niu, J., Xu, H., Zeng, G., Wang, P., Raciheon, B., Nawaz, S., Zeng, Z., & Zhao, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-33522-3 · Cited by 12
Gut Microbiome in Impulsively Violent Female Convicts
Langmajerová, M., Ježková, J., Kreisinger, J., Semerád, J., Titov, I., Procházková, P., Cajthaml, T., Jiřička, V., Vevera, J., & Roubalová, R. (2024) · Neuropsychobiology · doi:10.1159/000542220 · Cited by 12
Neurodevelopment and climate change
Nunes, M. L., & da Cunha, A. J. L. A. (2024) · Jornal de Pediatria · doi:10.1016/j.jped.2024.10.005 · Cited by 15
Bacteria Engineered to Produce Serotonin Modulate Host Intestinal Physiology
Mavros, C. F., Bongers, M., Neergaard, F. B. F., Cusimano, F. A., Sun, Y., Kaufman, A., Richardson, M., Kammler, S., Kristensen, M., Sommer, M. O. A., et al. (2024) · ACS Synthetic Biology · doi:10.1021/acssynbio.4c00453 · Cited by 10
Psychobiotic Protection of Nutritional Supplements and Probiotics in Patients Undergoing Hemodialysis: A Randomized Trial
Climent, E., Hevilla, F., Padial, M., Barril, G., Blanca, M., Jiménez-Salcedo, T., López-Picasso, M., Nogueira-Pérez, Á., & Olveira, G. (2025) · Nutrients · doi:10.3390/nu17040652 · Cited by 10
The mediating roles of obesity indicators and serum albumin in the association of DEET exposure with depression and sleep disorders in adults: evidence from NHANES 2007-2016
Zhu, H., Tao, R., Yu, Q., Yu, M., Zhou, Y., & Fu, Q. (2025) · BMC Public Health · doi:10.1186/s12889-025-22880-4 · Cited by 12
The role of gut microbiota in modulating brain structure and psychiatric disorders: A Mendelian randomization study
Ye, Z., Gao, Y., Yuan, J., Chen, F., Xu, P., & Liu, W. (2025) · NeuroImage · doi:10.1016/j.neuroimage.2025.121292 · Cited by 16
The Role of Gut-Brain Tryptophan Metabolism and Fatty Acid Peroxidation in the Effect of Sleep Deprivation on Anxiety and Depression in PCOS Mice
Han, T. L., Liu, S., Liu, H., Wang, X., Yang, X., Chan, S., Tumanov, S., Cannon, R. D., Yang, Y., & Han, T.-L. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05099-7 · Cited by 12
A novel on-a-chip system with a 3D-bioinspired gut mucus suitable to investigate bacterial endotoxins dynamics
Sardelli, L., Campanile, M., Boeri, L., Donnaloja, F., Fanizza, F., Perottoni, S., Petrini, P., Albani, D., & Giordano, C. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100898 · Cited by 10
The Microbiome-Gut-Brain Axis: A New Window to View the Impact of Prenatal Stress on Early Neurodevelopment
Rotem‐Kohavi, N., Keane, J., Clarke, G. A., Dinan, T. G., Cryan, J. F., McCarthy, F. P., Oberlander, T. F., & O’Mahony, S. M. (2021) · Springer eBooks · doi:10.1007/978-3-030-60159-1_8 · Cited by 9
Self-citation
Abnormalities in the composition of the gut microbiota in mice after repeated administration of DREADD ligands
Guo, W., Wan, X., Ma, L., Zhang, J., & Hashimoto, K. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.05.012 · Cited by 9
Superior cervical ganglionectomy alters gut microbiota in rats.
Zhang, W., Li, Y., Sun, T., Li, Z., Manyande, A., Xu, W., Feng, M., & Xiang, H. (2022) · PubMed Central · Cited by 9
Depression-like behaviors in mouse model of Sjögren's syndrome: A role of gut–microbiota–brain axis
Pu, Y., He, Y., Zhao, X., Zhang, Q., Wen, J., Hashimoto, K., & Liu, Y. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173448 · Cited by 9
Hypomagnetic Field Exposure Affecting Gut Microbiota, Reactive Oxygen Species Levels, and Colonic Cell Proliferation in Mice
Zhan, A., Luo, Y., Qin, H., Lin, W., & Tian, L. (2022) · Bioelectromagnetics · doi:10.1002/bem.22427 · Cited by 9
Association between Blastocystis and body mass index in healthy subjects; a theoretical pilot study
Mirjalali, H., Latifi, A., Taghipour, A., Yadegar, A., Hatami, B., Sadeghi, A., Ehsani, M. J., & Zali, M. R. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-019-00483-2 · Cited by 9
Current Paradigms to Explore the Gut Microbiota Linkage to Neurological Disorders
Sharma, V., Sankhyan, A., Varshney, A., Choudhary, R., & Sharma, A. K. (2020) · EMJ Neurology · doi:10.33590/emjneurol/20-00068 · Cited by 9
Exploring gut microbiota profile induced by antipsychotics in schizophrenic patients: insights from an Eastern European pilot study
Nita, I.-B., Văcărean-Trandafir, I.-C., Amărandi, R.-M., Ilie, O., Dobrin, R., Bejenariu, A. C., Ivanov, I.-C., & Doroftei, B. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07461-4 · Cited by 8
From Dysbiosis to Distress: The Gut–Brain Connection in Trauma-Related Disorders
Marano, G., Giudice, L. L., Specogna, E., Chisari, L., Brisi, C., Traversi, G., Mazza, O., & Mazza, M. (2026) · Nutrients · doi:10.3390/nu18030530 · Cited by 9
Alterations of the gut microbiota in type 2 diabetics with or without subclinical hypothyroidism
Lv, Y., Liu, R., Jia, H., Sun, X., Gong, Y., Ma, L., Qiu, W., & Wang, X. (2023) · PeerJ · doi:10.7717/peerj.15193 · Cited by 8
Brain-gut microbiome profile of neuroticism predicts food addiction in obesity: A transdiagnostic approach
Zhang, X., Bhatt, R. R., Todorov, S., & Gupta, A. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110768 · Cited by 8
Assessment of Self-Reported Executive Function in Patients with Irritable Bowel Syndrome Using a Machine-Learning Framework
Lundervold, A. J., Hillestad, E. M. R., Lied, G. A., Billing, J., Johnsen, T. E., Steinsvik, E. K., Hausken, T., Berentsen, B., & Lundervold, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12113771 · Cited by 8
The Potential of Hydrogen for Improving Mental Disorders
Satoh, Y. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666201113095938 · Cited by 8
O eixo intestino-cérebro e sintomas depressivos: uma revisão sistemática dos ensaios clínicos randomizados com probióticos
Souzedo, F. B., Bizarro, L., & de Pereira, A. P. A. (2020) · Jornal Brasileiro de Psiquiatria · doi:10.1590/0047-2085000000285 · Cited by 17
Probiotics: current regulatory aspects of probiotics for use in different disease conditions
Pogačar, M. Š., Mičetić‐Turk, D., & Fijan, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00021-0 · Cited by 9

Authors: Dinan, T. G., & Cryan, J. F.
Affiliations: University College Cork (IE)
Corresponding author: Dinan, Timothy G.
ORCID: Dinan, Timothy G.
Cryan, John F.
Venue: Psychosomatic Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2017-10
Volume: 79
Issue: 8
Pages: 920-926
ISSN: 0033-3174 (ISSN-L)
1534-7796
DOI: 10.1097/psy.0000000000000519
OpenAlex: W2743330831
Cited by: 325
References: 65
Citations by year: 2026: 26 · 2025: 35 · 2024: 35 · 2023: 46 · 2022: 45 · 2021: 47 · 2020: 49 · 2019: 26 · 2018: 13 · 2017: 3
FWCI: 2.33
Type: journal article
Language: en
Open access: closed
Locations: Psychosomatic Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: brain-gut-microbiota axis, gut microbiota, mental health, mental illness, dysbiosis, psychobiotics, probiotics, Bifidobacterium longum, two-way communication, functional MRI, brain electrical activity
MeSH terms: Gastrointestinal Microbiome, Animals, Mental Disorders, Brain, Humans, Signal Transduction, Probiotics, Dysbiosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Brain-Gut-Microbiota Axis and Mental Health

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks