The microbiome-gut-brain axis in health and disease
Open accessAbstract
Gut microbes are capable of producing most neurotransmitters found in the human brain. Evidence is accumulating to support the view that gut microbes influence central neurochemistry and behavior. Irritable bowel syndrome is regarded as the prototypic disorder of the brain-gut-microbiota axis that can be responsive to probiotic therapy. Translational studies indicate that certain bacteria may have an impact on stress responses and cognitive functioning. Manipulating the gut microbiota with psychobiotics, prebiotics, or even antibiotics offers a novel approach to altering brain function and treating gut-brain axis disorders, such as depression and autism.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
During gut pathologies with increased permeability of the intestinal barrier, translocation of bacterial products can increase production of cytokines and impact the blood-brain barrier, leading to more intense harmful effects.
“during gut pathologies with increased permeability of the intestinal barrier, the translocation of bacterial products can increase the production of cytokines and impact the blood-brain barrier (BBB), leading to more intense harmful effects (37).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [37]
The IBS as prototype section reports rodent evidence that stress alters the gut barrier, allowing LPS into the bloodstream and stimulating inflammatory cytokine production. Brain-gut-microbiota communication says cytokines can signal across the BBB and influence brain areas, but does not say this process damages the BBB or leads to more intense harmful effects. The paper also cautions that the proposed inflammatory mechanism has not been definitively demonstrated in depression; no page numbers were available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe microbiota is altered in CNS diseases, which aggravates the condition, and/or its modulation might prevent or improve the development and progression of CNS pathologies.
“The central hypothesis is supported by experimental and clinical evidence that the microbiota is altered in such diseases, which aggravates the condition, and/or its modulation might prevent or improve the development and progression of CNS pathologies (17, 19, 29, 33–37).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [37]
The Parkinson’s disease and Autism sections (pages not provided) report altered microbiota in patients and improvement of abnormal behaviours after microbiota treatment in an animal model. But the paper cautions that much of the human evidence is correlational and says there is no clear indication of treatment efficacy in diseased populations. It does not establish that microbiota changes aggravate CNS diseases generally or that modulation prevents their progression. (LLM, conf=0.84)
Experimental — accuracy not yet measuredSeveral brain disorders have been linked to imbalances in the microbial composition of the gut.
“several brain disorders have been linked to imbalances in the microbial composition of the gut (17, 19, 29, 33–37)”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [37]
Gut microbes can produce certain neurotransmitters and influence the central neurochemistry of the brain and thus human behavior.
“Gut microbes have, for example, been found to be capable of producing certain neurotransmitters and of influencing the central neurochemistry of the brain and thus human behavior (136).”
From Cytokine Research in Depression: Principles, Challenges, and Open Questions (2019) · cites this paper as [136]
Leaky gut causes translocation of lipopolysaccharide of Gram-negative bacteria, which results in activation of the immune system (Toll-like receptors) and production of pro-inflammatory cytokines (IL-6, IFN-γ, CRP, TNF-α).
“It causes a translocation of lipopolysaccharide (LPS) of Gram-negative bacteria which results in activation of the immune system (Toll-like receptors -TLRs) and production of pro-inflammatory cytokines (IL-6, IFN-γ, CRP, TNF-α) [1,5,44].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [1]
The key communication routes between the enteric microbiota and the brain are the vagal nerve, tryptophan metabolites, and microbial products such as short-chain fatty acids or peptidoglycan.
“The key communication routes between the enteric microbiota and the brain are vagal nerve, tryptophan metabolites, and microbial products, such as short-chain fatty acids (SCFAs) or peptidoglycan [1,17,24].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [1]
The GM can modulate host physiological processes through microbial constituents, microbial products, hormone release, and substrate metabolism.
“As a key regulator, the GM can modulate host physiological processes through several proposed mechanisms (25, 26).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works
Self-citationGut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
Short-chain fatty acids in control of body weight and insulin sensitivity
Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298 · see citing works
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232 · see citing works
Gut microbiota are related to Parkinson's disease and clinical phenotype
Scheperjans, F., Aho, V., Pereira, P. A. B., Koskinen, K., Paulin, L., Pekkonen, E., Haapaniemi, E., Kaakkola, S., Eerola‐Rautio, J., Pohja, M., et al. (2015) · Movement Disorders · doi:10.1002/mds.26069 · Cited by 1,968 · see citing works
Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683 · see citing works
Self-citationPrinciples and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · see citing works
Psychobiotics: A novel class of psychotropic
Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287 · see citing works
Self-citationConsumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192 · see citing works
Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110 · see citing works
Self-citationO'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069 · see citing works
Self-citationGut microbes and the brain: paradigm shift in neuroscience
Mayer, E. A., Knight, R., Mazmanian, S. K., Cryan, J. F., & Tillisch, K. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3299-14.2014 · Cited by 1,033 · see citing works
Self-citationEffects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999 · see citing works
Self-citationBrain-gut-microbe communication in health and disease
Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952 · see citing works
Self-citationMicrobiota is essential for social development in the mouse
Desbonnet, L., Clarke, G., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.65 · Cited by 866 · see citing works
Self-citationVagotomy and subsequent risk of <scp>P</scp> arkinson's disease
Svensson, E., Horváth‐Puhó, E., Thomsen, R. W., Djurhuus, J. C., Pedersen, L., Borghammer, P., & Sørensen, H. T. (2015) · Annals of Neurology · doi:10.1002/ana.24448 · Cited by 806 · see citing works
The role of microbiome in central nervous system disorders
Wang, Y., & Kasper, L. H. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.015 · Cited by 803 · see citing works
Steenbergen, L., Sellaro, R., van Hemert, S., Bosch, J. A., & Colzato, L. S. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.04.003 · Cited by 671 · see citing works
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637 · see citing works
Dinan, T. G., Quigley, E. M. M., Ahmed, S. M. M., Scully, P., O’Brien, S., O’Mahony, L., O’Mahony, S., Shanahan, F., & Keeling, P. W. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.033 · Cited by 636 · see citing works
Self-citationGastrointestinal microbiota in children with autism in Slovakia
Tomova, A., Husarova, V., Lakatosova, S., Bakos, J., Vlkova, B., Babinska, K., & Ostatnikova, D. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.10.033 · Cited by 632 · see citing works
Collective unconscious: How gut microbes shape human behavior
Dinan, T. G., Stilling, R. M., Stanton, C., & Cryan, J. F. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.02.021 · Cited by 571 · see citing works
Self-citationSchmidt, K., Cowen, P. J., Harmer, C. J., Tzortzis, G., Errington, S., & Burnet, P. W. J. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3810-0 · Cited by 522 · see citing works
Microbiota and host determinants of behavioural phenotype in maternally separated mice
De Palma, G., Blennerhassett, P., Lu, J., Deng, Y., Park, A. J., Green, W., Denou, E., Silva, M. A., Santacruz, A., Sanz, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms8735 · Cited by 517 · see citing works
Establishment and development of intestinal microbiota in preterm neonates
Arboleya, S., Binetti, A. G., Salazar, N., Fernández, N., Sánchez, G. S., Hernández‐Barranco, A. M., Margollés, A., Reyes‐Gavilán, C. G. D. L., & Gueimonde, M. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01261.x · Cited by 439 · see citing works
The microbiome: stress, health and disease
Moloney, R. D., Desbonnet, L., Clarke, G., Dinan, T. G., & Cryan, J. F. (2014) · Mammalian Genome · doi:10.1007/s00335-013-9488-5 · Cited by 430 · see citing works
Self-citationMaternal separation as a model of brain-gut axis dysfunction
O’Mahony, S. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2010-9 · Cited by 415 · see citing works
Gut microbiota in autism and mood disorders
Mangiola, F. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i1.361 · Cited by 413 · see citing works
Lyte, M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003726 · Cited by 399 · see citing works
Didari, T. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i10.3072 · Cited by 356 · see citing works
The Impact of Microbiota on Brain and Behavior: Mechanisms & Therapeutic Potential
Borre, Y. E., Moloney, R. D., Clarke, G., Dinan, T. G., & Cryan, J. F. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_17 · Cited by 329 · see citing works
Self-citationIncreased salivary cortisol after waking in depression
Bhagwagar, Z., Hafizi, S., & Cowen, P. J. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0062-z · Cited by 281 · see citing works
The impact of gut microbiota on brain and behaviour
Dinan, T. G., & Cryan, J. F. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000221 · Cited by 267 · see citing works
Self-citationProgramming of Host Metabolism by the Gut Microbiota
Bäckhed, F. (2011) · Annals of Nutrition and Metabolism · doi:10.1159/000328042 · Cited by 256 · see citing works
The microbiota-gut-brain axis and its potential therapeutic role in autism spectrum disorder
Li, Q., & Zhou, J.-M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.013 · Cited by 253 · see citing works
Takada, M., Nishida, K., Kataoka‐Kato, A., Gondo, Y., Ishikawa, H., Suda, K., Kawai, M., Hoshi, R., Watanabe, O., Igarashi, T., et al. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12804 · Cited by 243 · see citing works
Microbial Endocrinology and the Microbiota-Gut-Brain Axis
Lyte, M. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_1 · Cited by 227 · see citing works
Marshall, J. K., Thabane, M., Garg, A. X., Clark, W. F., Moayyedi, P., Collins, S. M., & Walkerton Health Study Investigators (2010) · Gut · doi:10.1136/gut.2009.202234 · Cited by 227 · see citing works
Dynamics and Clinical Evolution of Bacterial Gut Microflora in Extremely Premature Patients
Jacquot, A., Neveu, D., Aujoulat, F., Mercier, G., Marchandin, H., Jumas‐Bilak, E., & Picaud, J. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.09.007 · Cited by 224 · see citing works
Gut Microbiota: The Conductor in the Orchestra of Immune–Neuroendocrine Communication
El Aidy, S., Dinan, T. G., & Cryan, J. F. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.03.002 · Cited by 215 · see citing works
Self-citationMicrobiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms
Felice, V. D., Quigley, E. M., Sullivan, A. M., O'Keeffe, G. W., & O'Mahony, S. M. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.03.012 · Cited by 205 · see citing works
Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?
O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.068 · Cited by 203 · see citing works
Self-citationImmune modulation of the brain-gut-microbe axis
Aidy, S. E., Dinan, T. G., & Cryan, J. F. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00146 · Cited by 163 · see citing works
Self-citationPark, S. H., Videlock, E. J., Shih, W., Presson, A. P., Mayer, E. A., & Chang, L. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12826 · Cited by 156 · see citing works
The effects of gut microbiota on CNS function in humans
Tillisch, K. (2014) · Gut Microbes · doi:10.4161/gmic.29232 · Cited by 144 · see citing works
Fermented foods, neuroticism, and social anxiety: An interaction model
Hilimire, M. R., DeVylder, J., & Forestell, C. A. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.04.023 · Cited by 95 · see citing works
IBS: an epigenetic perspective
Dinan, T. G., Cryan, J. F., Shanahan, F., Keeling, P. W. N., & Quigley, E. M. M. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.99 · Cited by 90 · see citing works
Self-citationSondheimer, J. M., Clark, D. A., & Gervaise, E. P. (1985) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-198506000-00005 · Cited by 88 · see citing works
Systematic review of evidence to support the theory of psychobiotics
Romijn, A. R., & Rucklidge, J. J. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv025 · Cited by 81 · see citing works
Duodenal Microflora in Very-Low-Birth-Weight Neonates and Relation to Necrotizing Enterocolitis
Hoy, C. M., Wood, C. M., Hawkey, P. M., & Puntis, J. W. L. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.12.4539-4547.2000 · Cited by 76 · see citing works
Chang, J. Y., Shin, S. M., Chun, J., Lee, J., & Seo, J. K. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318227e518 · Cited by 63 · see citing works
Characterization of gastrointestinal disorders in patients with parkinsonian syndromes
Park, H.-Y., Lee, J., Shin, C. M., Kim, J., Kim, T. J., & Kim, J. W. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.02.005 · Cited by 59 · see citing works
Probiotic ‘glow of health’: it's more than skin deep
Erdman, S. E., & Poutahidis, T. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0042 · Cited by 56 · see citing works
The Brain-Gut Axis: A Target for Treating Stress-Related Disorders
Scott, L. V., Clarke, G. A., & Dinan, T. G. (2013) · Modern trends in psychiatry · doi:10.1159/000343971 · Cited by 46 · see citing works
Self-citationValeur, J., Undseth, R., Jakobsdottir, G., NYMAN, M. E., & Berstad, A. (2015) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s94084 · Cited by 24 · see citing works
Definition of preterm delivery.
Dennison, B. (1976) · BMJ · doi:10.1136/bmj.2.6049.1449-a · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- [8]8. Svensson E, Horvath-Puho E, Thomsen RW, et al. Vagotomy and subsequent risk of Parkinson's disease. Annals of neurology. Oct 2015;78(4):522-529.
- [29]29. Sondheimer JM, Clark DA. Gastric pH in healthy preterm infants -effect of age and feeding type. Gastroenterology. 1985 1985;88(5):1593-1593.
- [45]45. Chini B, Leonzino M, Braida D, Sala M. Learning about oxytocin: pharmacologic and behavioral issues. Biological psychiatry. Sep 1 2014;76(5):360-366.
- [46]46. Shen H. Neuroscience: The hard science of oxytocin. Nature. Jun 25 2015;522(7557):410-412.
Cited by
Sorted by citations
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043 · see citing works
“Noteworthy, during gut pathologies with increased permeability of the intestinal barrier, the translocation of bacterial products can increase the production of cytokines and impact the bloodbrain barrier (BBB), leading to more intense harmful effects (37).”
BackgroundThe Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857 · see citing works
Shaping the Future of Probiotics and Prebiotics
Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., Grimaldi, R., Guyonnet, D., Holscher, H. D., Hunter, K., Manurung, S., Obis, D., et al. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.01.003 · Cited by 637 · see citing works
Antibiotics, gut microbiota, and Alzheimer’s disease
Angelucci, F., Cechova, K., Amlerova, J., & Hort, J. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1494-4 · Cited by 454 · see citing works
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder
Srikantha, P., & Mohajeri, M. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092115 · Cited by 400 · see citing works
Tamtaji, O. R., Taghizadeh, M., Daneshvar Kakhaki, R., Kouchaki, E., Bahmani, F., Borzabadi, S., Oryan, S., Mafi, A., & Asemi, Z. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.05.018 · Cited by 398 · see citing works
RetractedDan, Z., Mao, X., Liu, Q., Guo, M., Zhuang, Y., Liu, Z., Chen, K., Chen, J., Xu, R., Tang, J., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1747329 · Cited by 350 · see citing works
Deng, Y., Zhou, M., Wang, J., Yao, J., Yu, J., Liu, W., Wu, L., Wang, J., & Gao, R. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1869501 · Cited by 362 · see citing works
Understanding dental caries as a non-communicable disease
Pitts, N. B., Twetman, S., Fisher, J., & Marsh, P. D. (2021) · British Dental Journal · doi:10.1038/s41415-021-3775-4 · Cited by 346 · see citing works
Insular cortex neurons encode and retrieve specific immune responses
Koren, T., Yifa, R., Amer, M., Krot, M., Boshnak, N., Ben-Shaanan, T. L., Azulay-Debby, H., Zalayat, I., Avishai, E., Hajjo, H., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.013 · Cited by 334 · see citing works
Brain-Gut-Microbiota Axis and Mental Health
Dinan, T. G., & Cryan, J. F. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000519 · Cited by 325 · see citing works
Self-citationCytokine Research in Depression: Principles, Challenges, and Open Questions
Himmerich, H., Patsalos, O., Lichtblau, N., Ibrahim, M. A. A., & Dalton, B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00030 · Cited by 313 · see citing works
Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study
Zhang, B., Wang, H. E., Bai, Y.-M., Tsai, S.-J., Su, T.-P., Chen, T.-J., Wang, Y.-P., & Chen, M.-H. (2021) · Gut · doi:10.1136/gutjnl-2020-320789 · Cited by 292 · see citing works
The Impact of Disease Comorbidities in Alzheimer’s Disease
Santiago, J. A., & Potashkin, J. A. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.631770 · Cited by 259 · see citing works
Gut Microbiota Features in Young Children With Autism Spectrum Disorders
Coretti, L., Paparo, L., Riccio, M. P., Amato, F., Cuomo, M., Natale, A., Borrelli, L., Corrado, G., De Caro, C., Comegna, M., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03146 · Cited by 266 · see citing works
Chen, D., Yang, X., Yang, J., Lai, G., Yong, T., Tang, X., Shuai, O., Zhou, G., Xie, Y., & Wu, Q. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00403 · Cited by 227 · see citing works
Paediatric functional abdominal pain disorders
Thapar, N., Benninga, M. A., Crowell, M. D., Di Lorenzo, C., Mack, I., Nurko, S., Saps, M., Shulman, R. J., Szajewska, H., van Tilburg, M. A. L., et al. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00222-5 · Cited by 221 · see citing works
Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works
Wasser, C. I., Mercieca, E.-C., Kong, G., Hannan, A. J., McKeown, S. J., Glikmann-Johnston, Y., & Stout, J. C. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa110 · Cited by 198 · see citing works
Ge, L., Liu, S., Li, S., Yang, J., Hu, G., Xu, C., & Song, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1016578 · Cited by 187 · see citing works
Gómez-Eguílaz, M., Ramón-Trapero, J. L., Pérez-Martínez, L., & Blanco, J. R. (2018) · Beneficial Microbes · doi:10.3920/bm2018.0018 · Cited by 177 · see citing works
Microbiota-gut brain axis involvement in neuropsychiatric disorders
Iannone, L. F., Preda, A., Blottière, H. M., Clarke, G., Albani, D., Belcastro, V., Carotenuto, M., Cattaneo, A., Citraro, R., Ferraris, C., et al. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1638763 · Cited by 177 · see citing works
Parkinson’s Disease and the Gastrointestinal Microbiome
Lubomski, M., Tan, A. H., Lim, S.-Y., Holmes, A. J., Davis, R. L., & Sue, C. M. (2020) · Journal of Neurology · doi:10.1007/s00415-019-09320-1 · Cited by 172 · see citing works
Best practice update: Incorporating psychogastroenterology into management of digestive disorders
Keefer, L., Palsson, O. S., & Pandolfino, J. E. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.01.045 · Cited by 173 · see citing works
Ansari, F., Pourjafar, H., Tabrizi, A., & Homayouni, A. (2020) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201021666200107113812 · Cited by 170 · see citing works
The gut microbiome and irritable bowel syndrome
Menees, S., & Chey, W. (2018) · F1000Research · doi:10.12688/f1000research.14592.1 · Cited by 159 · see citing works
Fecal microbiota transplantation beyond Clostridioides difficile infections
Wortelboer, K., Nieuwdorp, M., & Herrema, H. (2019) · eBioMedicine · doi:10.1016/j.ebiom.2019.05.066 · Cited by 163 · see citing works
Chen, L., Liu, B., Ren, L., Du, H., Fei, C., Qian, C., Li, B., Zhang, R., Liu, H., Li, Z., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1069954 · Cited by 155 · see citing works
Microbiota influence the development of the brain and behaviors in C57BL/6J mice
Lu, J., Synowiec, S., Lu, L., Yu, Y., Bretherick, T., Takada, S., Yarnykh, V., Caplan, J., Caplan, M., Claud, E. C., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201829 · Cited by 159 · see citing works
Xiao, L., Yan, J., Yang, T., Zhu, J., Li, T., Wei, H., & Chen, J. (2021) · mSystems · doi:10.1128/msystems.01343-20 · Cited by 141 · see citing works
da Silva, T. F., Glória, R. D. A., Americo, M. F., Freitas, A. D. S., de Jesus, L. C. L., Barroso, F. A. L., Laguna, J. G., Coelho-Rocha, N. D., Tavares, L. M., le Loir, Y., et al. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10247-x · Cited by 117 · see citing works
Can we ‘seize’ the gut microbiota to treat epilepsy?
De Caro, C., Iannone, L. F., Citraro, R., Striano, P., De Sarro, G., Constanti, A., Cryan, J. F., & Russo, E. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.002 · Cited by 110 · see citing works
Self-citationEnduring behavioral effects induced by birth by caesarean section in the mouse
Morais, L. H., Golubeva, A. V., Moloney, G. M., Moya-Pérez, A., Ventura-Silva, A. P., Arboleya, S., Bastiaanssen, T. F. S., O’Sullivan, O., Rea, K., Borre, Y., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.07.044 · Cited by 104 · see citing works
Self-citationJadhav, K. S., Peterson, V. L., Halfon, O., Ahern, G., Fouhy, F., Stanton, C., Dinan, T. G., Cryan, J. F., & Boutrel, B. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.08.026 · Cited by 101 · see citing works
Self-citationMills, S., Lane, J. A., Smith, G. J., Grimaldi, K. A., Ross, R. P., & Stanton, C. (2019) · Nutrients · doi:10.3390/nu11071468 · Cited by 88 · see citing works
Sawada, D., Kuwano, Y., Tanaka, H., Hara, S., Uchiyama, Y., Sugawara, T., Fujiwara, S., Rokutan, K., & Nishida, K. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.04.022 · Cited by 76 · see citing works
Zhu, Y., Huan, F., Wang, J., Xie, X., Yu, G., Wang, X., Jiang, L., Gao, R., Xiao, H., Ding, H., et al. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00475 · Cited by 48 · see citing works
Gorlé, N., Blaecher, C., Bauwens, E., Vandendriessche, C., Balusu, S., Vandewalle, J., Van Cauwenberghe, C., Van Wonterghem, E., Van Imschoot, G., Liu, C., et al. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.12.010 · Cited by 49 · see citing works
Novel Nutraceutical Compounds in Alzheimer Prevention
Maccioni, R. B., Calfío, C., González, A., & Lüttges, V. (2022) · Biomolecules · doi:10.3390/biom12020249 · Cited by 45 · see citing works
Keskitalo, A., Aatsinki, A.-K., Kortesluoma, S., Pelto, J., Korhonen, L., Lahti, L., Lukkarinen, M., Munukka, E., Karlsson, H., & Karlsson, L. (2021) · Stress · doi:10.1080/10253890.2021.1895110 · Cited by 44 · see citing works
Depressive symptoms predict clinical recurrence of inflammatory bowel disease
Jordi, S. B. U., Lang, B. M., Auschra, B., von Känel, R., Biedermann, L., Greuter, T., Schreiner, P., Rogler, G., Krupka, N., Sulz, M. C., et al. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab136 · Cited by 41 · see citing works
Edebol Carlman, H. M. T., Rode, J., König, J., Repsilber, D., Hutchinson, A. N., Thunberg, P., Persson, J., Kiselev, A., Pruessner, J. C., & Brummer, R. J. (2022) · Nutrients · doi:10.3390/nu14071329 · Cited by 37 · see citing works
Zhang, B., Wang, H. E., Bai, Y., Tsai, S., Su, T., Chen, T., Wang, Y., & Chen, M. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15855 · Cited by 27 · see citing works
Lewis, N., Villani, A., & Lagopoulos, J. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.031 · Cited by 25 · see citing works
Onisiforou, A., & Spyrou, G. M. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab141 · Cited by 23 · see citing works
High-speed mapping of whole-mouse peripheral nerves at subcellular resolution
Shi, M.-Y., Yao, Y., Wang, M., Yang, Q., Ding, L., Li, R., Li, Y., Huang, H., Yang, C.-Y., Zhou, Z., et al. (2025) · Cell · doi:10.1016/j.cell.2025.06.011 · Cited by 18 · see citing works
- Authors
- Dinan, T. G., & Cryan, J. F.
- Affiliations
- University College Cork (IE)
- Corresponding author
- Dinan, Timothy G.
- Venue
- Gastroenterology Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 46
- Issue
- 1
- Pages
- 77-89
- ISSN
- 0889-8553 (ISSN-L)
- OpenAlex
- W2568352511
- Semantic Scholar
- 424e004cc64ef5ae3b336d9828672bd17ca6d334
- Cited by
- 1,111
- References
- 60
- Citations by year
- 2026: 118 · 2025: 146 · 2024: 147 · 2023: 111 · 2022: 145 · 2021: 167 · 2020: 115 · 2019: 94 · 2018: 48 · 2017: 19
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- Funders
- Alimentary Pharmabiotic Centre (SFI/12/RC/2273)
- Health Research Board of Ireland (HRA_POR/2011/23, HRA_POR/2012/32)
- European Community’s Seventh Framework Programme (FP7/2007-2013)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut-brain axis, gut microbiota, neurotransmitters, tryptophan, serotonin, GABA, Bifidobacterium, lactobacilli, irritable bowel syndrome, probiotics, psychobiotics, prebiotics, vagus nerve, short-chain fatty acids, cytokines, depression, autism spectrum disorder, Parkinson's disease, stress response, cognitive function
- MeSH terms
- Gastrointestinal Microbiome, Animals, Autistic Disorder, Brain, Depression, Fatty Acids, Volatile, gamma-Aminobutyric Acid, Humans, Parkinson Disease, Tryptophan, Vagus Nerve, Cytokines, Probiotics, Gastrointestinal Tract, Irritable Bowel Syndrome, Prebiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
