The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Role of Depression, Stress, and Trauma in HIV Disease Progression
Abstract
Despite advances in HIV treatment, there continues to be great variability in the progression of this disease. This paper reviews the evidence that depression, stressful life events, and trauma account for some of the variation in HIV disease course. Longitudinal studies both before and after the advent of highly active antiretroviral therapies (HAART) are reviewed. To ensure a complete review, PubMed was searched for all English language articles from January 1990 to July 2007. We found substantial and consistent evidence that chronic depression, stressful events, and trauma may negatively affect HIV disease progression in terms of decreases in CD4 T lymphocytes, increases in viral load, and greater risk for clinical decline and mortality. More research is warranted to investigate biological and behavioral mediators of these psychoimmune relationships, and the types of interventions that might mitigate the negative health impact of chronic depression and trauma. Given the high rates of depression and past trauma in persons living with HIV/AIDS, it is important for healthcare providers to address these problems as part of standard HIV care.
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“The resulting consensus from this body of work is that acute life events (e.g., getting divorced or fired from a job) and chronic difficulties (e.g., ongoing marital or financial problems) increase risk for a wide variety of mental and physical health problems, including anxiety disorders, depression, autoimmune disorders, cardiovascular disease, certain cancers, and Alzheimer's disease (6–10).”
From Assessing Lifetime Stress Exposure Using the Stress and Adversity Inventory for Adults (Adult STRAIN): An Overview and Initial Validation (2018) · cites this paper as [9]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
DiMatteo, M. R., Lepper, H. S., & Croghan, T. W. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.14.2101 · Cited by 4,177
Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection
Paterson, D. L., Swindells, S., Mohr, J. A., Brester, M., Vergis, E. N., Squier, C. L., Wagener, M. M., & Singh, N. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-1-200007040-00004 · Cited by 3,289
Stress and immunity in humans: a meta-analytic review.
Herbert, T. B., & Cohen, S. (1993) · Psychosomatic Medicine · doi:10.1097/00006842-199307000-00004 · Cited by 1,100
Mortality, CD4 Cell Count Decline, and Depressive Symptoms Among HIV-Seropositive Women
Ickovics, J. R., Hamburger, M. E., Vlahov, D., Schoenbaum, E. E., Schuman, P. C., BOLAND, R. J., & Moore, J. (2001) · JAMA · doi:10.1001/jama.285.11.1466 · Cited by 885
Depression and immunity: A meta-analytic review.
Herbert, T. B., & Cohen, S. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.113.3.472 · Cited by 812
Bower, J. E., Kemeny, M. E., Taylor, S. E., & Fahey, J. L. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.66.6.979 · Cited by 465
Leserman, J., Jackson, E. D., Petitto, J. M., Golden, R. N., Silva, S. G., Perkins, D. O., Cai, J., Folds, J. D., & Evans, D. L. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199905000-00021 · Cited by 441
Self-citationEstrogen Replacement Therapy and Ovarian Cancer Mortality in a Large Prospective Study of US Women
Rodríguez, C. (2001) · JAMA · doi:10.1001/jama.285.11.1460 · Cited by 424
Depressive Symptoms and AIDS-Related Mortality Among a Multisite Cohort of HIV-Positive Women
Cook, J. Α., Grey, D. D., Burke-Miller, J. K., Cohen, M. H., Gurtman, A., Richardson, J. L., Wilson, T. E., Young, M., & Hessol, N. A. (2004) · American Journal of Public Health · doi:10.2105/ajph.94.7.1133 · Cited by 396
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A Handbook for the Study of Mental Health Second Edition
Scheid, T. L., & Brown, T. N. (2009) · Cited by 1,320
HIV Stigma Mechanisms and Well-Being Among PLWH: A Test of the HIV Stigma Framework
Earnshaw, V. A., Smith, L. R., Chaudoir, S. R., Amico, K. R., & Copenhaver, M. M. (2013) · AIDS and Behavior · doi:10.1007/s10461-013-0437-9 · Cited by 805
Depression and HIV/AIDS Treatment Nonadherence: A Review and Meta-analysis
Gonzalez, J. S., Batchelder, A., Psaros, C., & Safren, S. A. (2011) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31822d490a · Cited by 820
Mental health and HIV/AIDS: the need for an integrated response
Remien, R. H., Stirratt, M. J., Nguyen, N., Robbins, R. N., Pala, A. N., & Mellins, C. A. (2019) · AIDS · doi:10.1097/qad.0000000000002227 · Cited by 727
Ten Surprising Facts About Stressful Life Events and Disease Risk
Cohen, S., Murphy, M. L. M., & Prather, A. A. (2019) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-102857 · Cited by 531
Metadata
- Authors
- Leserman, J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Leserman, Jane
- Venue
- Psychosomatic Medicine
- Published
- 2008-06
- Volume
- 70
- Issue
- 5
- Pages
- 539-545
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2018119542
- Cited by
- 662
- References
- 63
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 22 · 2023: 18 · 2022: 35 · 2021: 37 · 2020: 35 · 2019: 45 · 2018: 43 · 2017: 86 · 2016: 47 · 2015: 35 · 2014: 38 · 2013: 44 · 2012: 50
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Complementary and Integrative Health (R01AT002035)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- HIV disease progression, depression, stress, trauma, life events, CD4 count, viral load, clinical deterioration, mortality, psychoneuroimmunology, highly active antiretroviral therapy, psychosocial interventions
- MeSH terms
- Depressive Disorder, Health Services Needs and Demand, Humans, Life Change Events, Longitudinal Studies, Patient Care Team, Patient Compliance, Psychoneuroimmunology, Risk Factors, Stress, Psychological, HIV Infections, Comorbidity, Disease Progression, CD4 Lymphocyte Count, Viral Load, Antiretroviral Therapy, Highly Active
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