The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Deciphering the serological response to syphilis treatment in men living with HIV
Abstract
Objective To examine syphilis serology after treatment in people living with HIV. No unanimous guidelines exist in the era of increasing coinfection. Design Retrospective review using a tertiary care clinic in Toronto from 2000 to 2017. Methods The 2015 Centers for Diseases Control and Prevention syphilis guidelines were used to define an adequate serologic response. Cumulative distribution estimates and proportional hazards models accounting for interval censoring estimated the time to serologic response and seroreversion. Multistate models were used to investigate extended periods of serofast serology. Results A total of 171 patients with syphilis met our inclusion criteria (16 primary, 53 secondary, 26 early latent, 46 late latent, 30 neurosyphilis). Serologic response was achieved by 12 months for 65 (94%) patients and by 12-18 months for four (6%) patients with primary/secondary syphilis. For latent and neurosyphilis, 94 (92%) achieved serologic response by 24 months and one (1%) at 24.1 months. 84 (49%) patients achieved seroreversion with a median (95% confidence interval) time of 2 (1.44, 2.68) years. Latent syphilis was associated with a lower likelihood of achieving serologic response [hazard ratio (HR) = 0.52, P = 0.05] and seroreversion (HR = 0.27, P Conclusion The majority of people living with HIV infected with syphilis will achieve an adequate serologic response as per the Centers for Diseases Control and Prevention guidelines. Seroreversion was observed in abo…
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“The post-treatment non-treponemal serological response is delayed at 6 months as compared to individuals without HIV”
From BASHH UK guidelines for the management of syphilis 2024 (2024) · cites this paper as [141]
In the citing paper
“but this difference is not significant at 12 months after treatment.128,141,142”
From BASHH UK guidelines for the management of syphilis 2024 (2024) · cites this paper as [141]
Citations
Cites
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BASHH UK guidelines for the management of syphilis 2024
Kingston, M., Apea, V., Evans, C., Fifer, H., Foster, K., Patrick, P., Grant, A., Manns, V., Ramsden, S., Sinka, K., et al. (2024) · International Journal of STD & AIDS · doi:10.1177/09564624241280406 · Cited by 51
Metadata
- Authors
- Ren, M., Szadkowski, L., & Walmsley, S. L.
- Affiliations
- University Health Network (CA)
- Biostatistical Research Unit
- Corresponding author
- Ren, Melody
- Szadkowski, Leah
- Venue
- AIDS
- Published
- 2020-08-08
- Volume
- 34
- Issue
- 14
- Pages
- 2089-2096
- ISSN
- 0269-9370 (ISSN-L)
- 1473-5571
- OpenAlex
- W3048508055
- Cited by
- 10
- References
- 2
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- AIDS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Syphilis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
- Keywords
- syphilis, HIV coinfection, serological response, seroreversion, latent syphilis, neurosyphilis, syphilis treatment, multi-state models
- MeSH terms
- Adult, Canada, Female, Humans, Male, Middle Aged, Neurosyphilis, Penicillin G Benzathine, Retrospective Studies, Syphilis, Syphilis Serodiagnosis, HIV Infections, Antiretroviral Therapy, Highly Active, Coinfection
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