The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort study
Open accessAbstract
OBJECTIVE: To describe trends in incidence rates of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) during the HIV epidemic and to evaluate predictors, including the impact of antiretroviral therapy, of cancer development. DESIGN: Retrospective analysis of a multicenter, prospective natural history study including 4498 HIV-infected US military beneficiaries with 33 486 person-years of follow-up. METHODS: Predictors evaluated included demographics, clinical data, time-updated CD4 cell counts, HIV viral loads, and antiretroviral history. Time periods were classified as early pre (1984-1990), late pre (1991-1995), early post (1996-2000), and late post (2001-2006) HAART eras. Cox proportional hazard models were used to evaluate the association of specific factors with cancer. RESULTS: Ten percent of HIV-infected persons developed cancer. ADC rates increased between the early and late pre-HAART eras (7.6 and 14.2 cases per 1000 person-years) and have since declined from 5.4 to 2.7 in the early and late HAART eras, respectively (P < 0.001). Rates of NADCs have risen over the four periods (2.9, 2.8, 4.2, 6.7, P = 0.0004). During the late HAART era, 71% of cancers were NADCs. Predictors for ADCs included low CD4 cell count, noncancer AIDS diagnosis, and lack of HAART. NADCs were predicted by increasing age and white race (due to skin cancers). CONCLUSION: Although the rate of ADCs continues to fall, the rate of NADCs is rising and now accounts for the majority of cancers in HIV-infected persons. The development of NADCs is associated with increasing age among HIV patients. HAART use is protective for ADCs, but did not significantly impact NADCs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Palella, F. J., Delaney, K. M., Moorman, A. C., Loveless, M. O., Fuhrer, J., Satten, G. A., Aschman, D. J., & Holmberg, S. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803263381301 · Cited by 9,405
Castro, K. G., Ward, J. W., Slutsker, L., Buehler, J. W., Jaffe, H. W., Berkelman, R. L., & Curran, J. W. (1993) · Clinical Infectious Diseases · doi:10.1093/clinids/17.4.802 · Cited by 4,349
(2006) · PsycEXTRA Dataset · doi:10.1037/e545592006-001 · Cited by 2,958
Grulich, A. E., van Leeuwen, M. T., Falster, M. O., & Vajdic, C. M. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61050-2 · Cited by 2,323
Kaposi's sarcoma and Pneumocystis pneumonia among homosexual men--New York City and California.
Friedman‐Kien, A. E., Laubenstein, L. J., Marmor, M. F., Hymes, K. B., Green, J., Ragaz, A., Gottleib, J., Muggia, F. M., Demopoulos, R. I., & Weintraub, M. R. (1981) · PubMed · Cited by 1,091
Treatment for Adult HIV Infection: 2006 Recommendations of the International AIDS Society–USA Panel
Hammer, S. M., Saag, M. S., Schechter, M., Montaner, J. S. G., Schooley, R. T., Jacobsen, D. M., Thompson, M. A., Carpenter, C. C. J., Fischl, M. A., Gazzard, B. G., et al. (2006) · JAMA · doi:10.1001/jama.296.7.827 · Cited by 1,033
(1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03500040022009 · Cited by 958
Clifford, G. M., Polesel, J., Rickenbach, M., Study, O. B. O. T. S. H. C., Dal Maso, L., Keiser, O., Kofler, A., Rapiti, E., Levi, F., Jundt, G., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji072 · Cited by 863
Improved Survival Among HIV-Infected Individuals Following Initiation of Antiretroviral Therapy
Hogg, R. S. (1998) · JAMA · doi:10.1001/jama.279.6.450 · Cited by 850
Association of Cancer With AIDS-Related Immunosuppression in Adults
Frisch, M. (2001) · JAMA · doi:10.1001/jama.285.13.1736 · Cited by 821
Cited by
AIDS-defining opportunistic illnesses in US patients, 1994–2007: a cohort study
Buchacz, K., Baker, R. K., Palella, F. J., Chmiel, J. S., Lichtenstein, K. A., Novak, R. M., Wood, K. C., & Brooks, J. T. (2010) · AIDS · doi:10.1097/qad.0b013e32833a3967 · Cited by 332
HIV infection and the risk of cancers with and without a known infectious cause
Silverberg, M. J., Chao, C., Leyden, W. A., Xu, L., Tang, B., Horberg, M. A., Klein, D., Quesenberry, C. P., Towner, W. J., & Abrams, D. I. (2009) · AIDS · doi:10.1097/qad.0b013e3283319184 · Cited by 299
Cobucci, R. N. O., Lima, P. H., de Souza, P. C., Costa, V. V., Cornetta, M. D. C. D. M., Fernandes, J. V., & Gonçalves, A. K. (2015) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2014.08.003 · Cited by 175
Dhokotera, T., Bohlius, J., Spoerri, A., Egger, M., Ncayiyana, J., Olago, V., Singh, E., & Sengayi, M. (2019) · Infectious Agents and Cancer · doi:10.1186/s13027-019-0228-7 · Cited by 72
Long-term cancer risk among people diagnosed with AIDS during childhood
Simard, E. P., Shiels, M. S., Bhatia, K., & Engels, E. A. (2012) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0823 · Cited by 50
Metadata
- Authors
- Crum-Cianflone, N., Hullsiek, K. H., Marconi, V., Weintrob, A., Ganesan, A., Barthel, R. V., Fraser, S., Agan, B. K., & Wegner, S.
- Venue
- AIDS
- Published
- 2009-01-02
- Volume
- 23
- Issue
- 1
- Pages
- 41-50
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W1984647905
- Cited by
- 278
- References
- 31
- FWCI
- 12.63
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort study. https://app.cochat.ai/papers/10.1097/qad.0b013e328317cc2d
- The paper
- Crum-Cianflone, N., Hullsiek, K. H., Marconi, V., Weintrob, A., Ganesan, A., Barthel, R. V., Fraser, S., Agan, B. K., & Wegner, S. (2009). Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort study. AIDS. https://doi.org/10.1097/qad.0b013e328317cc2d
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
