The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
AIDS-defining opportunistic illnesses in US patients, 1994–2007: a cohort study
Abstract
OBJECTIVES: To assess the incidence and spectrum of AIDS-defining opportunistic illnesses in the highly active antiretroviral therapy (cART) era. DESIGN: A prospective cohort study of 8070 participants in the HIV Outpatient Study at 12 U.S. HIV clinics. METHODS: We calculated incidence rates per 1000 person-years of observation for the first opportunistic infection, first opportunistic malignancy, and first occurrence of each individual opportunistic illness during 1994-2007. Using stratified Poisson regression models, and adjusting for sex, race, and HIV risk category, we modeled annual percentage changes in opportunistic illness incidence rates by calendar period. RESULTS: Eight thousand and seventy patients (baseline median age 38 years; median CD4 cell count 298 cells/microl) experienced 2027 incident opportunistic illnesses during a median of 2.9 years of observation. During 1994-1997, 1998-2002, and 2003-2007, respectively, rates of opportunistic infections (per 1000 person-years) were 89.0, 25.2 and 13.3 and rates of opportunistic malignancies were 23.4, 5.8 and 3.0 (P for trend <0.001 for both). Opportunistic illness rate decreases were similar for the subset of patients receiving cART. During 2003-2007, there were no significant changes in annual rates of opportunistic infections or opportunistic malignancies; the leading opportunistic illnesses (rate per 1000 person-years) were esophageal candidiasis (5.2), Pneumocystis pneumonia (3.9), cervical cancer (3.5), Mycobacterium avium complex infection (2.5), and cytomegalovirus disease (1.8); 36% opportunistic illness events occurred at CD4 cell counts at least 200 cells/microl. CONCLUSIONS: Opportunistic illness rates declined precipitously after introduction of cART and stabilized at low levels during 2003-2007. In this contemporary cART era, a third of opportunistic illnesses were diagnosed at CD4 cell counts at least 200 cells/microl.
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AIDS across Europe, 1994–98: the EuroSIDA study
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Cobucci, R. N. O., Lima, P. H., de Souza, P. C., Costa, V. V., Cornetta, M. D. C. D. M., Fernandes, J. V., & Gonçalves, A. K. (2015) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2014.08.003 · Cited by 175
Estimating the burden of invasive and serious fungal disease in the United Kingdom
Pegorie, M., Denning, D. W., & Welfare, W. (2017) · Journal of Infection · doi:10.1016/j.jinf.2016.10.005 · Cited by 104
Serious fungal infections in Thailand
Chayakulkeeree, M., & Denning, D. W. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-2927-6 · Cited by 43
Burden of serious fungal infections in Tanzania
Faini, D., Maokola, W., Furrer, H., Hatz, C., Battegay, M., Tanner, M., Denning, D. W., & Letang, E. (2015) · Mycoses · doi:10.1111/myc.12390 · Cited by 42
Metadata
- Authors
- Buchacz, K., Baker, R. K., Palella, F. J., Chmiel, J. S., Lichtenstein, K. A., Novak, R. M., Wood, K. C., & Brooks, J. T.
- Venue
- AIDS
- Published
- 2010-06-19
- Volume
- 24
- Issue
- 10
- Pages
- 1549-1559
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2013979648
- Cited by
- 332
- References
- 28
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- closed
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